BA.1 breakthrough infection elicits distinct antibody and memory B cell responses in vaccinated-only versus hybrid immunity individuals
iScience,
Год журнала:
2025,
Номер
28(4), С. 111962 - 111962
Опубликована: Фев. 6, 2025
Immune
memory
is
influenced
by
the
frequency
and
type
of
antigenic
challenges.
Here,
we
performed
a
cross-sectional
comparison
immune
parameters
following
BA.1
breakthrough
infection
in
individuals
with
prior
hybrid
immunity
(conferred
vaccination)
versus
those
solely
vaccinated
cohort
health
care
workers
Lyon,
France.
The
results
showed
higher
levels
serum
anti-receptor
binding
domain
(RBD)
antibodies
neutralizing
against
post-infection
vaccine-only
group.
Individuals
this
group
also
decrease
B
cells
ancestral
strain
but
an
increase
specific
cross-reactive
to
BA.1,
suggesting
more
limited
imprinting.
Conversely,
prevents
antibody
dependent
cellular
cytotoxicity
(ADCC)
response,
possibly
limiting
IgG4
class-switching
enhanced
anti-N
responses
post-infection.
This
highlights
that
induces
different
depending
on
history
vaccination
infection,
which
should
be
considered
for
further
guidelines.
Язык: Английский
Enhanced RBD-Specific Antibody Responses and SARS-CoV-2-Relevant T-Cell Activity in Healthcare Workers Following Booster Vaccination
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(10), С. 11124 - 11135
Опубликована: Окт. 2, 2024
COVID-19
continues
to
impact
healthcare
workers
(HCWs),
making
it
crucial
investigate
vaccine
response
rates.
This
study
examined
HCWs’
humoral
and
cellular
immunological
responses
booster
dosages.
We
enrolled
thirty-four
vaccinated
HCWs.
Twelve
received
a
booster.
Post-immunization,
the
participants’
anti-COVID-19
IgG
antibodies
IFN-γ
secretion
were
assessed.
The
median
second
immunization
time
was
406.5
days.
Eighteen
of
twenty-two
(81.8%)
experienced
breakthrough
infections
after
vaccination,
whereas
ten
out
twelve
individuals
who
doses
had
(83.3%).
Six
HCWs
(17.6%)
no
infections.
Booster-injection
recipients
antibody
titer
19,592
AU/mL,
compared
7513.55
AU/mL.
with
exhibited
13,271.9
7770.65
AU/mL
for
those
without
Breakthrough-infection
booster-injection
groups
slightly
higher
T-cell
antigens
1,
2,
3.
SARS-CoV-2
responsiveness
positively
associated.
sustain
immunity
over
10
months.
Irrespective
type
vaccine,
injections
enhance
these
immune
responses.
results
our
research
are
consistent
previous
studies,
multicenter
investigation
could
validate
findings.
Язык: Английский
Immune Response Dynamics to SARS-CoV-2 in the Albanian Population: A Study on T-Cell and Antibody Interactions During the Transition From Pandemic to Endemic Phase
Infectious Diseases & Immunity,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 17, 2024
Abstract
Background:
The
coronavirus
disease
2019
(COVID-19)
pandemic
has
resulted
in
a
dynamic
evolution
of
the
immune
response
to
Severe
Acute
Respiratory
Syndrome
Coronavirus
2
(SARS-CoV-2),
initially
characterized
by
primary
responses
and
later
secondary
due
mass
vaccination
viral
variants.
Understanding
interplay
between
humoral
(antibody)
cellular
(T-cell)
immunity
is
crucial
for
effective
public
health
strategies.
This
study
aims
evaluate
correlation
T-cell
antibody
levels
sample
adult
Albanian
population
during
transition
COVID-19
from
an
endemic
phase.
rationale
this
investigation
generate
data
that
can
inform
ongoing
management
COVID-19,
particularly
context
monitoring,
ensure
strategies
remain
as
virus
becomes
more
permanent
population.
Methods:
cross-sectional
observational
involved
individuals
over
18
years
age
who
were
randomly
selected
at
intervals
every
20
records
family
doctor
registries
five
urban
centers
Tirana
Berat,
Albania,
January
23
April
3,
2023.
Participants
provided
demographic
data,
including
infection
history.
Blood
samples
analyzed
using
Interferon-gamma
(IFN-γ)
release
assay
enzyme-linked
immunosorbent
measure
anti-spike
(S1)
anti-nucleoprotein
(N)
IgG
antibodies.
Statistical
analyses
conducted
examine
relationships
IFN-γ,
anti-S1,
anti-N
antibodies
factors
such
status,
prior
infections,
reinfection
rates.
These
employed
bivariate
multivariate
approaches,
Fisher’s
exact
test,
Mann–Whitney
U
Kruskal–Wallis
linear
multiple
regression
analyses,
Spearman’s
coefficient
test.
Results:
164
(54.7%
female,
median
43
years).
Of
these
individuals,
62.8%
(103/164)
vaccinated,
primarily
with
Pfizer-BioNTech
vaccine.
IFN-γ
positivity
was
detected
95.1%
(156/164),
anti-S1
93.3%
(153/164).
Significant
correlations
observed
(
r
=
0.502;
P
<
0.001).
Vaccinated
exhibited
significantly
higher
than
unvaccinated
0.05).
Reinfections
prevalent
vaccinated
(26.2%
[16/61]
vs.
12.6%
[13/103],
0.034).
According
analysis,
correlated
protection
against
(regression
β
–0.003;
0.042),
while
did
not
exhibit
–1.659;
0.146).
Conclusion:
Vaccination,
especially
when
combined
previous
infection,
boosts
both
SARS-CoV-2.
close
indicates
mount
robust
response.
lower
rates
among
highlight
importance
sustained
protection.
Assessing
could
be
beneficial
immunocompromised
making
decisions
about
revaccination.
highlights
critical
role
comprehensive
monitoring
offers
insights
future
Язык: Английский