Complexes of Ruthenium(II) as Promising Dual-Active Agents against Cancer and Viral Infections

Pharmaceuticals, Год журнала: 2023, Номер 16(12), С. 1729 - 1729

Опубликована: Дек. 15, 2023

Poor responses to medical care and the failure of pharmacological treatment for many high-frequency diseases, such as cancer viral infections, have been widely documented. In this context, numerous metal-based substances, including cisplatin, auranofin, various gold metallodrugs, ruthenium complexes, are under study possible anticancer antiviral agents. The two Ru(III) Ru(II) namely, BOLD-100 RAPTA-C, presently being studied in a clinical trial preclinical studies evaluation, respectively, Interestingly, has also recently demonstrated activity against SARS-CoV-2, which is virus responsible COVID-19 pandemic. Over last years, much effort dedicated discovering new dual anticancer-antiviral Ru-based complexes could be very suitable respect. Thus, review focuses on most recent regarding newly synthesized use and/or

Язык: Английский

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Utilization of ruthenium(0) for σ-bond activation: Formation of organoruthenium complexes and emergence of their catalytic activity via in situ Ru-C bond cleavage

Journal of Organometallic Chemistry, Год журнала: 2025, Номер unknown, С. 123567 - 123567

Опубликована: Фев. 1, 2025

Язык: Английский

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Iridium(I) complexes with fluorinated N-heterocyclic carbene and phosphine ligands for the transfer hydrogenation catalysis of ketones and aldehydes

Journal of Organometallic Chemistry, Год журнала: 2025, Номер unknown, С. 123718 - 123718

Опубликована: Май 1, 2025

Язык: Английский

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Carbon dioxide hydrogenation to formate catalyzed by highly active Ru-tris(pyrazolyl)methane complexes

Journal of Catalysis, Год журнала: 2025, Номер unknown, С. 116231 - 116231

Опубликована: Май 1, 2025

Язык: Английский

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Effect of 1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) on the ruthenium-catalyzed transfer hydrogenation of ketones

Journal of Catalysis, Год журнала: 2025, Номер unknown, С. 116248 - 116248

Опубликована: Июнь 1, 2025

Язык: Английский

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Hoveyda-Grubbs type complexes with ruthenium-pnictogen/halcogen/halogen coordination bond. Synthesis, catalytic activity, applications.

Russian Chemical Reviews, Год журнала: 2024, Номер 93(8), С. RCR5132 - RCR5132

Опубликована: Авг. 1, 2024

Catalytic olefin metathesis using Hoveyda-Grubbs-type ruthenium complexes is a powerful tool for creating complex molecules possessing variety of practically useful properties. This method also applied obtaining modern polymer materials from low-demand petroleum products. Among all containing five- or six-membered chelate rings, the commercially available HG-II catalyst most common. In addition, other complexes, which include Het→Ru donor-acceptor bond in ring, often exhibit activity equal to superior that HG-II. review considers second-generation N-heterocyclic carbene with bonds such as O→Ru, S→Ru, Se→Ru, N→Ru, P→Ru and Hal→Ru ring. Methods preparation, analysis stability catalytic are compared, examples application these organometallic derivatives synthesis relevant products provided. The literature 2010 2023 summarized, making this broad audience chemists working heterocyclic chemistry, well practitioners involved production catalysts polymers. Bibliography includes 174 references.

Язык: Английский

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Ruthenium-based macrocyclic and Schiff base complexes as prominent therapeutic agents: Their designing, synthesis and recent perspectives

Polyhedron, Год журнала: 2024, Номер 266, С. 117309 - 117309

Опубликована: Ноя. 17, 2024

Язык: Английский

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