Advanced Synthesis & Catalysis,
Год журнала:
2022,
Номер
364(16), С. 2815 - 2821
Опубликована: Июль 11, 2022
Abstract
The
α‐alkylation
of
ketones
utilizing
a
secondary
alcohol
has
been
accomplished
by
an
isolable,
bench‐stable,
inexpensive
nickel
catalyst
affording
high
yields
β,β‐disubstituted
products.
This
report
contributes
in
the
pool
few
scarce
examples
base
metal
discovered
for
this
purpose.
substrate
scope
can
span
wide
range
including
aliphatic,
alicyclic,
and
cyclic
alcohols.
Functionalization
cholesterol
molecule
is
also
possible
following
methodology.
interconvert
between
azo
hydrazo
form
reversible
fashion
to
enable
chemical
transformation.
magnified
image
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(9), С. 6039 - 6057
Опубликована: Апрель 26, 2023
A
series
of
cascade
reactions
that
produce
a
range
functionalized
aromatic
heterocyclic
compounds
with
pyrazole/pyrazoline
cores
have
been
developed.
The
method
relies
on
metal-free
dehydrogenative
process
to
in-situ
benzaldehydes.
produced
benzaldehyde
was
then
allowed
react
some
other
substances,
including
acetophenone,
pyrazole
amine,
and
phenylhydrazine.
intermediate
from
these
substrates
underwent
several
chemical
processes,
electrocyclization,
the
aza-Diels-Alder
reaction,
formation
intramolecular
C-N
bonds.
These
positive
outcomes
would
open
up
possibility
producing
biologically
active
pyrazolo[3,4-b]pyridine
pyrazoline
derivatives
through
variety
possible
reactions.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(4), С. 2494 - 2504
Опубликована: Фев. 7, 2024
We
report
the
atom-economic
and
sustainable
synthesis
of
biologically
important
3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide
(DHBD)
derivatives
from
readily
available
aromatic
primary
alcohols
2-aminobenzenesulfonamide
catalyzed
by
nickel(II)-N∧N∧S
pincer-type
complexes.
The
synthesized
nickel
complexes
have
been
well-studied
elemental
spectroscopic
(FT-IR,
NMR,
HRMS)
analyses.
solid-state
molecular
structure
complex
2
has
authenticated
a
single-crystal
X-ray
diffraction
study.
Furthermore,
series
(24
examples)
utilizing
3
mol
%
Ni(II)
catalyst
through
acceptorless
dehydrogenative
coupling
benzyl
with
benzenesulfonamide.
Gratifyingly,
catalytic
protocol
is
highly
selective
yield
up
to
93%
produces
eco-friendly
water/hydrogen
gas
as
byproducts.
control
experiments
plausible
mechanistic
investigations
indicate
that
in
situ
generated
aldehyde
benzenesulfonamide
leads
desired
product.
In
addition,
large-scale
one
thiadiazine
unveils
synthetic
usefulness
current
methodology.
ACS Catalysis,
Год журнала:
2024,
Номер
14(14), С. 10624 - 10634
Опубликована: Июнь 28, 2024
We
report
here
a
method
of
making
polyketones
from
the
coupling
diketones
and
diols
using
manganese
pincer
complex.
The
methodology
allows
us
to
access
various
(polyarylalkylketone)
containing
aryl,
alkyl,
ether
functionalities,
bridging
gap
between
two
classes
commercially
available
polyketones:
aliphatic
polyaryletherketones.
Using
this
methodology,
12
have
been
synthesized
characterized
analytical
techniques
understand
their
chemical,
physical,
morphological,
mechanical
properties.
Based
on
previous
reports
our
studies,
we
suggest
that
polymerization
occurs
via
hydrogen-borrowing
mechanism
involves
dehydrogenation
dialdehyde
followed
by
aldol
condensation
with
form
chalcone
derivatives
subsequent
hydrogenation
polyarylalkylketones.
Advanced Synthesis & Catalysis,
Год журнала:
2022,
Номер
364(16), С. 2815 - 2821
Опубликована: Июль 11, 2022
Abstract
The
α‐alkylation
of
ketones
utilizing
a
secondary
alcohol
has
been
accomplished
by
an
isolable,
bench‐stable,
inexpensive
nickel
catalyst
affording
high
yields
β,β‐disubstituted
products.
This
report
contributes
in
the
pool
few
scarce
examples
base
metal
discovered
for
this
purpose.
substrate
scope
can
span
wide
range
including
aliphatic,
alicyclic,
and
cyclic
alcohols.
Functionalization
cholesterol
molecule
is
also
possible
following
methodology.
interconvert
between
azo
hydrazo
form
reversible
fashion
to
enable
chemical
transformation.
magnified
image
