Recent advances on the synthesis and application of tetrahydro-γ-carbolines

Chinese Chemical Letters, Год журнала: 2023, Номер 34(12), С. 108657 - 108657

Опубликована: Июнь 7, 2023

Язык: Английский

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Recent advances in the synthetic applications of Morita–Baylis–Hillman and Rauhut–Currier adducts of nitroalkenes

Organic & Biomolecular Chemistry, Год журнала: 2023, Номер 21(31), С. 6243 - 6262

Опубликована: Янв. 1, 2023

This article reviews the recent applications of Morita–Baylis–Hillman and Rauhut–Currier adducts nitroalkenes. It also covers mechanistic aspects, including key intermediates reaction pathways.

Язык: Английский

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Organocatalytic Regio- and Enantioselective Allylic Alkylation of Indolin-2-imines with MBH Carbonates toward 3-Allylindoles

The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(12), С. 7810 - 7814

Опубликована: Янв. 26, 2023

An organocatalytic asymmetric C3-allylic alkylation of indolone-2-imines with MBH carbonates has been developed for the first time. As opposed to previous reports, an "interrupted" annulation was achieved, affording 3-allylindoles in generally high yields excellent stereoselectivities. The representative scale-up reaction and transformation were examined. A possible mechanism also proposed.

Язык: Английский

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One-pot π-extension approach of iminoindoles-to-α-carbolines as blue-light emitters using the cooperative basic system

New Journal of Chemistry, Год журнала: 2024, Номер 48(32), С. 14163 - 14169

Опубликована: Янв. 1, 2024

Efficient access to α-carbolines was achieved via a domino reaction between iminoindoles and arylidene malononitriles using DABCO/NaHCO 3 as cooperative basic system. The synthesized scaffolds display blue emissions with good quantum yields.

Язык: Английский

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Enantioselective Synthesis of 3‐Allylindoles from Indolin‐2‐imines and MBH Carbonates via Nucleophilic Catalysis

ChemistrySelect, Год журнала: 2024, Номер 9(6)

Опубликована: Фев. 7, 2024

Abstract With chiral amine (DHQD) 2 PHAL as nucleophilic catalyst, asymmetric synthesis of enantioenriched 3‐allylindoles was achieved from indolone‐2‐imines and MBH carbonates. Compared with our previous phosphine catalysis, the had exactly opposite effect in terms enantioselectivity. Importantly, we could obtain each enantiomer by adjusting catalyst system.

Язык: Английский

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Synthesis of α-, β-, and γ-Carbolines via Intramolecular Cyclization of Azidomethyl(indolyl)acrylates Involving PIFA-BF₃·OEt₂/DBU-Mediated Cyclization as well as Thermolysis Approaches

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(14), С. 9867 - 9887

Опубликована: Июль 2, 2024

In this study, we present our findings on the synthesis of α-, β-, γ-carbolines via PIFA/BF

Язык: Английский

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Novel access to α-carbolines with biological applications

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 276, С. 116700 - 116700

Опубликована: Июль 20, 2024

Язык: Английский

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Visible Light‐Mediated Reactions of β‐Nitroalkenes

Asian Journal of Organic Chemistry, Год журнала: 2022, Номер 12(1)

Опубликована: Ноя. 17, 2022

Abstract Organic transformations using visible light‐mediated photoredox reactions received significant attention in the past several years. Recently, nitroalkenes have emerged as an excellent coupling partner reactions. Due to easy availability and diverse reactivity, methodologies are reported on photoredox‐mediated of attain different types alkenes heterocycles. Variety including denitrative reactions, addition cycloadditions, etc. reported. However, a review that focuses entirely this topic has not appeared yet. Considering synthetic potential these class we provide summary various developed for under light catalysis.

Язык: Английский

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Highly diastereoselective [3+3] cycloaddition of indolin-3-ones and nitroallylic acetates: Efficient access to polysubstituted dihydropyrano[3,2-b]indoles

Tetrahedron, Год журнала: 2023, Номер 133, С. 133275 - 133275

Опубликована: Янв. 20, 2023

Язык: Английский

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Baylis–Hillmanadducts as an important synthon for the synthesis of α‐carbolinone and α‐carboline derivatives

Journal of Heterocyclic Chemistry, Год журнала: 2023, Номер 60(6), С. 957 - 965

Опубликована: Фев. 20, 2023

Abstract Baylis–Hillman adducts were conveniently transformed into α‐carbolinone and α‐carboline derivatives by monoalkylation of 2‐nitrobenzylcyanide, imide formation/Friedel–Crafts cyclization, treatment with Fe/AcOH in simple process is described.

Язык: Английский

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