Unconventional reactivity of sulfonyl fluorides
Trends in Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Chemoselective Reactions of Functionalized Sulfonyl Halides
The Chemical Record,
Год журнала:
2023,
Номер
24(2)
Опубликована: Окт. 12, 2023
Abstract
Chemoselective
transformations
of
functionalized
sulfonyl
fluorides
and
chlorides
are
surveyed
comprehensively.
It
is
shown
that
provide
an
excellent
selectivity
control
in
their
reactions.
Thus,
numerous
conditions
tolerated
by
the
SO
2
F
group
–
from
amide
ester
formation
to
directed
ortho
‐lithiation
transition‐metal‐catalyzed
cross‐couplings.
Meanwhile,
sulfur
(VI)
fluoride
exchange
(SuFEx)
also
compatible
with
functional
groups,
thus
confirming
its
title
“another
click
reaction”.
On
contrary,
a
few
exceptions,
most
typically
occur
at
Cl
moiety.
Язык: Английский
A General Protocol for the Chemo- and Stereoselective Construction of α,β-Unsaturated γ-Amino Sulfonyl Fluorides
Synthesis,
Год журнала:
2023,
Номер
55(20), С. 3373 - 3381
Опубликована: Авг. 15, 2023
Abstract
A
general
protocol
for
the
simple,
efficient,
and
mild
synthesis
of
α,β-unsaturated
γ-amino
sulfonyl
fluorides
is
developed
via
a
base-catalyzed
N-alkylation
reaction
aromatic
amines
with
(E)-3-bromoprop-1-ene-1-sulfonyl
fluoride.
This
transformation
exhibits
excellent
chemo-
stereoselectivity,
conditions,
broad
functional
group
compatibility
operational
simplicity,
making
it
potentially
valuable
procedure
in
medicinal
chemistry,
chemical
biology,
drug
discovery.
Язык: Английский