A Brief Review on Different Reactions of Rhodanine

Journal of Heterocyclic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Окт. 23, 2024

ABSTRACT 2‐Thioxo‐4‐thiazolidinone which is trivially known as rhodanine a five‐membered heterocycle, containing sulfur and nitrogen atom at 1 3 positions, respectively. It very attractive class of compounds, because derivatization yields number molecules having multifarious application in medicinal chemistry biology. There are many derived from already being used commercially drug molecules. So owing to the importance field biology, comprehensive review familiarizing different derivatives parent molecule their syntheses highly warranted. In this review, we have broadly categorized reactions as; (a) Knoevenagel condensation through C‐5 active methylene group with carbonyl (b) nucleophilic attack on thioxo position 2 by aliphatic amines, (c) oxo conversion, (d) all other reactions. far, best our knowledge, no such literature accounts for kinds reported. Here, not only presented schemes various literatures, but discussed about advantages inadequacies that particular catalytic processes. Moreover, end article given own critical analysis these reports, based understanding experience.

Язык: Английский

In silico evaluation of 4-thiazolidinone-based inhibitors against the receptor for advanced glycation end products (RAGE)

Journal of Biomolecular Structure and Dynamics, Год журнала: 2023, Номер unknown, С. 1 - 12

Опубликована: Дек. 8, 2023

Non-enzymatic glycation of biomolecules by reducing sugars led to several products, including the advanced end products (AGEs), accumulation which has been linked various life-threatening diseases. The binding AGEs their respective protein receptors for (RAGE) can initiate a cascade reactions, may alter physiological conditions. present work investigates potential 4-thiazolidinones as RAGE inhibitors. We performed an extensive computational study identify structural requirements needed act To achieve this goal, 4-thiazolidinone-based compounds available in PubChem, ZINC15, ChEMBL, and ChEBI databases were screened against (PDB: 4LP5), leading identification top five drug-like candidates with high affinity V‐domain catalytic region. Drug likeness, absorption, distribution, metabolism, excretion, toxicity (ADMET) top-scoring have studied discussed. Global molecular descriptors, chemical reactivity, hardness, softness, etc., estimated. Finally, dynamics (MD) simulations at 100 ns carried out check stability other properties. Overall, we believe that identified potentially attenuate RAGE–AGE interactions.

Язык: Английский

Synthesis of new functionalized thiazolidin-4-ones by the condensation of thioureas with dialkyl acetylenedicarboxylates

Mendeleev Communications, Год журнала: 2024, Номер 34(4), С. 563 - 565

Опубликована: Июль 1, 2024

Язык: Английский