Synthesis of Aryl Alkyl Thioethers via a Copper-Catalyzed Three-Component Reaction with DABSO, Aryldiazonium Salts, and Alkyl Bromides

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 11, 2024

We developed a method for synthesizing aryl alkyl thioether compounds via three-component reaction involving aryldiazonium salts, 1,4-diazabicyclo[2.2.2]octane bis(sulfur dioxide), and bromides. Optimal yields were achieved when copper catalyst was used in conjunction with zinc tetrabutylammonium bromide an acetonitrile solvent at 130 °C 10 h. This methodology demonstrates good functional group tolerance enables the successful synthesis of various thioethers moderate to high yields.

Язык: Английский

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Electrochemical sulfonylation/Truce–Smiles rearrangement of N-allylbenzamides: toward sulfone-containing β-arylethylamines and Saclofen analogues

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(40), С. 8102 - 8108

Опубликована: Янв. 1, 2024

A practical electrochemical sulfonylation-triggered Truce–Smiles rearrangement of N -allylbenzamides yielded sulfone- and sulfonic acid-containing β-arylethylamines under mild oxidant-free reaction conditions.

Язык: Английский

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Bifunctional Sodium Dithionite Promoted Radical-Polar Crossover Cyclization: Diversified Synthesis of Functionalized Cyclic Sultines

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 11, 2024

A catalyst-free reductive radical-polar crossover cyclization with alkenes and sodium dithionite to construct densely functionalized cyclic sultines was described. The key the success of this practical protocol relies not only on a bifunctional role dithionite, that is, serving as radical initiator SO

Язык: Английский

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