Identification of three unexpected new psychoactive substances at an Australian drug checking service
Drug Testing and Analysis,
Год журнала:
2024,
Номер
16(10), С. 1144 - 1154
Опубликована: Янв. 11, 2024
Abstract
Drug
checking
is
a
harm
reduction
measure
that
provides
people
with
the
opportunity
to
confirm
identity
and
purity
of
substances
before
consumption.
The
CanTEST
Health
Checking
Service
Australia's
first
fixed‐site
drug
service,
where
clients
can
learn
about
contents
samples
they
provide
while
receiving
tailored
health
advice.
Three
were
recently
presented
service
expectation
4‐fluoromethylphenidate
(4F‐MPH)
1
,
methoxetamine
(MXE)
2
3‐methylmethcathinone
(3‐MMC)
3
.
all
three
did
not
meet
these
expectations
remained
unknown
on‐site,
as
no
high
confidence
identifications
obtained.
However,
further
analysis
by
nuclear
magnetic
resonance
spectroscopy,
resolution
gas
chromatography‐electron
ionisation‐mass
spectrometry
liquid
chromatography‐electrospray
at
nearby
Australian
National
University
allowed
for
structure
elucidation
4‐fluoro‐α‐pyrrolidinoisohexanophenone
(4F‐α‐PiHP)
4
1‐(4‐fluorobenzyl)‐4‐methylpiperazine
(4F‐MBZP)
5
N
‐propyl‐1,2‐diphenylethylamine
(propylphenidine)
6
respectively.
Given
expected
have
yet
been
described
new
psychoactive
in
literature,
this
study
presents
full
characterisation
each
compound.
As
exemplified
rapid
identification
unexpected
substances,
be
used
an
effective
method
monitor
unregulated
market.
Язык: Английский
Deoxygenative photochemical alkylation of secondary amides enables a streamlined synthesis of substituted amines
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 22, 2025
Abstract
Secondary
amines
are
vital
functional
groups
in
pharmaceuticals,
agrochemicals,
and
natural
products,
necessitating
efficient
synthetic
methods.
Traditional
approaches,
including
N
-monoalkylation
reductive
amination,
suffer
from
limitations
such
as
poor
chemoselectivity
complexity.
Herein,
we
present
a
streamlined
deoxygenative
photochemical
alkylation
of
secondary
amides,
enabling
the
synthesis
α-branched
amines.
Our
method
leverages
triflic
anhydride-mediated
semi-reduction
amides
to
imines,
followed
by
radical
step.
This
approach
broadens
utility
facilitating
late-stage
modifications
drug-like
molecules
saturated
-substituted
heterocycles.
The
pivotal
role
flow
technology
developing
scalable
robust
process
underscores
practicality
this
method,
significantly
expanding
organic
chemist’s
toolbox
for
complex
amine
synthesis.
Язык: Английский
Modular Synthesis of α‐Quaternary Chiral β‐Lactams via Three‐Component Asymmetric Kinugasa/Aldol or Kinugasa/Mannich Cascade Reactions
Chemistry - A European Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 7, 2024
The
β-lactam
scaffolds
are
the
prevalent
structural
units
in
antibiotics
and
natural
products.
Herein,
three-component
asymmetric
Kinugasa/aldol
Kinugasa/Mannich
cascade
reactions
have
been
developed
for
constructing
α-quaternary
chiral
β-lactams.
This
method
involved
tandem
reaction
of
alkynes,
nitrones
aldehydes
(or
imines),
resulting
formation
three
sequential
stereocenters
controlled
by
copper(I)
catalysts
bis(oxazolidine)
ligands.
protocol
features
high
enantioselectivity,
good
efficiency,
mild
operational
conditions,
representing
a
practical
sustainable
synthetic
tool
construction
functionalized
Язык: Английский