Palladium-Catalyzed Chelation-Assisted Aldehyde C–H Bond Activation of Quinoline-8-carbaldehydes: Synthesis of Amides from Aldehydes with Anilines and Other Amines

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(2), С. 1058 - 1063

Опубликована: Янв. 9, 2024

A palladium-catalyzed chelation-assisted direct aldehyde C–H bond amidation of quinoline-8-carbaldehydes with an amine was developed under mild reaction conditions. wide range amides were obtained in good to excellent yields from a variety aniline derivatives and aliphatic amines. Our methodology successfully applied synthesize known DNA intercalating agents can be easily scaled up gram scale.

Язык: Английский

Palladium (II)/Lewis Acid Catalyzed Oxidative Olefination of 2-Benzamidopyridine 1-Oxide with Acrylates: Synthesis of Isoindolinones

Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This work describes the development of a heterobimetallic Pd( ii )/Cu( )-catalyzed C–H olefination 2-benzamidopyridine 1-oxide with acrylates followed by intramolecular aza-Michael addition to construct desired isoindolinone core.

Язык: Английский

Progress on Cobalt-Catalyzed C(sp²)—H Activation for the Construction of Nitrogen-Containing Benzo Heterocycles

Chinese Journal of Organic Chemistry, Год журнала: 2025, Номер 45(2), С. 655 - 655

Опубликована: Янв. 1, 2025

Язык: Английский