An Organometallic Umpolung Approach for Iron‐Mediated Propargylic C–H Etherification

Angewandte Chemie, Год журнала: 2024, Номер unknown

Опубликована: Окт. 27, 2024

Abstract Propargylic ethers serve as useful intermediates for the synthesis of a variety complex targets. However, propargylic substitution prefunctionalized alkyne starting materials remains dominant method propargyl ethers, while direct etherification simple alkynes via C−H functionalization largely underreported. Herein, we report an organometallic umpolung approach iron‐mediated etherification. A telescopic protocol deprotonation followed by mild oxidative coupling with alcohols enabled use or functionalized expedient excellent functional group compatibility, chemoselectivity and regioselectivity.

Язык: Английский

Enantioselective Propargylic Substitution Reactions via Transition Metal–Allenylidene Complexes as Key Intermediates

Coordination chemistry research., Год журнала: 2024, Номер unknown, С. 100003 - 100003

Опубликована: Дек. 1, 2024

Язык: Английский

Advances in Catalytic Asymmetric Hydrogen-Phosphine/Phosphorus Functionalization of Unsaturated Carbon-Carbon Bonds

Chinese Journal of Organic Chemistry, Год журнала: 2024, Номер 44(12), С. 3647 - 3647

Опубликована: Янв. 1, 2024

Язык: Английский