ChemistrySelect, Год журнала: 2025, Номер 10(3)

Опубликована: Янв. 1, 2025

Abstract The phosphine‐catalyzed (3 + 2) annulation reaction of δ ‐hydroxyl‐substituted allenylic alcohols with pyrazolinone‐derived ketimines has been developed, giving a variety spiro dihydropyrrole‐dihydropyrazolone derivatives in high yields good diastereoselectivities. Various unsaturated and diverse worked well under mild conditions, 31 examples were provided up to 97% yield >20:1 diastereoselectivity. scale‐up further transformations the product successfully acheived, three derivation experiments showed feasibility product. These results revealed that current could be useful tool for synthesis derivatives. In addition, we also investigated asymmetric version this ketimines, 86% ee chiral was obtained use bifunctional phosphine catalyst.

Язык: Английский