Activation/Cyclization of 2H‐Azirines and 3‐Amino‐2‐fluoropyridines Towards 2‐Aryl‐Pyrido[2,3‐b]pyrazines DOI
Tess Fortier,

Audrey Belouin,

Frédéric Vuillermet

и другие.

European Journal of Organic Chemistry, Год журнала: 2024, Номер 27(24)

Опубликована: Апрель 22, 2024

Abstract The electrophilic activation of 2 H ‐azirines with triflic anhydride (Tf O) for an addition/cyclization reaction producing 2‐aryl‐pyrido[2,3‐ b ]pyrazines regioselectively is described. This proceeds via nucleophilic addition 3‐amino‐2‐fluoropyridines onto 1‐trifloyl‐aziridin‐2‐yl triflates and subsequent cyclization S N Ar. Desulfonylation oxidation provides a single regioisomer the aza‐bicyclic heterocycle after treatment Et 3 N. Optimization conditions lead to range in isolated yields 20 % 60 %.

Язык: Английский

Synthesis of spiroisoxazoline oxindoles by base-promoted annulation of oxime esters and isatins DOI
Si-Wei Chen,

Xu‐Hua Hu,

Ling Wu

и другие.

Tetrahedron Letters, Год журнала: 2025, Номер 159, С. 155506 - 155506

Опубликована: Март 6, 2025

Язык: Английский

Процитировано

0
Activation/Cyclization of 2H‐Azirines and 3‐Amino‐2‐fluoropyridines Towards 2‐Aryl‐Pyrido[2,3‐b]pyrazines DOI
Tess Fortier,

Audrey Belouin,

Frédéric Vuillermet

и другие.

European Journal of Organic Chemistry, Год журнала: 2024, Номер 27(24)

Опубликована: Апрель 22, 2024

Abstract The electrophilic activation of 2 H ‐azirines with triflic anhydride (Tf O) for an addition/cyclization reaction producing 2‐aryl‐pyrido[2,3‐ b ]pyrazines regioselectively is described. This proceeds via nucleophilic addition 3‐amino‐2‐fluoropyridines onto 1‐trifloyl‐aziridin‐2‐yl triflates and subsequent cyclization S N Ar. Desulfonylation oxidation provides a single regioisomer the aza‐bicyclic heterocycle after treatment Et 3 N. Optimization conditions lead to range in isolated yields 20 % 60 %.

Язык: Английский

Процитировано

0