Synthesis, Computational, and Photophysical Probing Interactions of Novel Isatin‐Incorporated Thiazolyl‐Coumarins as Potent Antitubercular Agents

ChemistrySelect, Год журнала: 2025, Номер 10(10)

Опубликована: Март 1, 2025

Abstract In this work, we reported the synthesis of a novel series isatin‐incorporated thiazolyl‐coumarin derivatives 4(a–h) by one‐pot three‐component reaction substituted isatin, thiosemicarbazide, and 3‐(2‐bromoacetyl) coumarin. The structures coumarin‐thiazole scaffolds were precisely established their IR, NMR, HRMS spectral data. UV–Vis absorption study target molecules was investigated in six different solvents. Geometrical optimization, molecular electrostatic potential regions, quantum chemical parameters assessed using density functional theory (DFT) to explore electronic properties derivatives. synthesized compounds screened for vitro antimycobacterial activity against Mycobacterium tuberculosis ; all exhibited excellent antitubercular efficacy with MIC ≤ 3.25 µg/mL; among them, 4c 4f most potent 1.56 µg/mL. Furthermore, silico docking analyses enoyl‐ACP reductase (InhA) enzyme conducted; ligands demonstrated favorable binding interactions within active site InhA enzyme.

Язык: Английский

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Synthesis, antiproliferative, antibacterial activity of acridone derivatives: Experimental and theoretical calculations

Journal of Molecular Structure, Год журнала: 2024, Номер 1316, С. 138841 - 138841

Опубликована: Июнь 7, 2024

Язык: Английский

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Skeletal Editing of Isatins for Heterocycle Molecular Diversity

The Chemical Record, Год журнала: 2024, Номер 24(6)

Опубликована: Июнь 1, 2024

Isatins have been widely used in the preparation of a variety heterocyclic compounds, where skeletal editing isatins has shown significant advantages for construction diverse heterocycles. This review highlights progress made last decade (2013-2023) isatin scaffold. A series ring expansion reactions quinoline skeleton, quinolone polycyclic quinazoline medium-sized as well opening generation 2-(azoly)aniline skeleton by cleavage C-C bond and C-N are highlighted. It is hoped that this will provide some understanding chemical transformations contribute to further realization its molecular diversity.

Язык: Английский

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Access to Spiro-Quinazolines via an Acid-Catalyzed Ring-Opening of Isatins with N-Alkylureas

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Herein, we report novel p-TSA·H2O-catalyzed ring-opening reactions of isatins with N-alkylureas, allowing access to spiro-quinazolines excellent substrate scope and good yields. Introducing N,N-dialkylureas, 2,4-thiazolidinedione, or rhodamine into the leads a distinct set three-component reactions, yielding innovative incorporating sulfur atoms. Notably, protocol achieves superior level atomic economy, water as sole byproduct.

Язык: Английский

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Synthesis, Characterization, Antimicrobial and In Silico Studies of isatin Schiff base linked 1,2,3‐triazole hybrids

Chemistry & Biodiversity, Год журнала: 2024, Номер 21(7)

Опубликована: Май 21, 2024

A new series of isatin-Schiff base linked 1,2,3-triazole hybrids has been synthesized using CuAAC approach from (E)-3-(phenylimino)-1-(prop-2-yn-1-yl)indolin-2-one derivatives in high yield (73-91 %). These were characterized FT-IR,

Язык: Английский

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Incredible Indolinedione Derivatives Nucleus in the Development of Anti‐Diabetic Drugs: Exploring the Mechanistic Studies, Design, and Structure‐Activity Relationship

ChemistrySelect, Год журнала: 2024, Номер 9(44)

Опубликована: Ноя. 1, 2024

Abstract Diabetes mellitus, a prevalent metabolic disorder, necessitates continuous exploration for innovative therapeutic agents. Indolinedione has garnered attention its potential as an antidiabetic scaffold structurally diverse nucleus. The search novel and effective agents led to the of natural compounds synthetic derivatives. review commences with in‐depth biochemical underpinnings diabetes emphasizing rational design strategies employed modifying indolinedione nucleus, encompassing various methodologies aimed at enhancing pharmacological properties docking studies. multifaceted derivatives offer fertile ground further in preclinical clinical As research this field progresses, may emerge valuable addition arsenal therapeutics, providing new avenues management mellitus.

Язык: Английский

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Novel Acylhydrazones Based on 1-Decylisatins and Girard Reagent T Possessing Antimicrobial Activity

Russian Journal of General Chemistry, Год журнала: 2024, Номер 94(11), С. 3099 - 3103

Опубликована: Ноя. 1, 2024

Язык: Английский

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