Electrocatalytic Anaerobic Oxidation of Benzylic Amines Enabled by Ferrocene-Based Redox Mediators
Organometallics,
Год журнала:
2024,
Номер
43(20), С. 2557 - 2564
Опубликована: Авг. 11, 2024
The
generation
and
functionalization
of
carbon-
or
nitrogen-centered
radicals
are
great
interest
for
their
potential
synthetic
utility.
Here,
we
report
the
anaerobic
electrocatalytic
oxidation
two
primary
benzylic
amines,
benzylamine
2-picolylamine,
in
presence
a
catalytic
quantity
an
electron
deficient
ferrocene
derivative
as
single-electron
redox
mediator.
use
appropriate
mediator
prevented
fouling
electrode
surface
significantly
decreased
at
which
reaction
occurred.
Simulation
electrochemical
results
revealed
E
Язык: Английский
Electrochemical Decarboxylative Trifluoromethylation of Cinnamic Acids Revisited: A Combined Experimental and Computational Study
Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
β-(Trifluoromethyl)styrenes
are
potentially
useful
building
blocks
for
the
synthesis
of
organofluorine
compounds
because
their
electron-deficient
C=C
double
bonds
can
undergo
diverse
transformations.
One
most
practical
methods
preparing
β-(trifluoromethyl)styrenes
is
decarboxylative
trifluoromethylation
readily
available
cinnamic
acid
derivatives
using
Langlois
reagent
as
a
less
expensive
trifluoromethyl
source.
We
revisited
electrochemical
to
identify
modified
conditions
that
reduce
loading
without
additional
additives.
The
reaction
mechanism
was
computationally
investigated
gain
insight
into
dependence
product
yields
on
aryl
terminal
groups.
synthetic
utility
obtained
demonstrated
by
transformation
4-aryl-3-(trifluoromethyl)pyrrolidines.
Язык: Английский