One-Pot Synthesis of N-Fused Quinolone-4 Tetracyclic Scaffolds from 2,2-Disubstituted Indolin-3-ones DOI Creative Commons
Nikolai A. Arutiunov, Anna M. Zatsepilina, Anna A. Aksenova

и другие.

ACS Omega, Год журнала: 2024, Номер 9(45), С. 45501 - 45517

Опубликована: Окт. 29, 2024

A cascade transformation of C2-quaternary indoxyls leading to an efficient assembly complex (dihydro)indolo[1,2-a]quinolin-5-one ring systems is reported. The method involves the gram-scale preparation 2-(2-aryl-3-oxoindolin-2-yl)-2-phenylacetonitriles which are then converted with methyl ketones corresponding 2-(2-oxo-2-aryl(alkyl)ethyl)-2-phenylindolin-3-ones. latter can either be isolated good yields (75–96%) or, in case o-nitroacetophenone, used situ for further base-assisted intramolecular SNAr cyclization resulting indoxyl-fused quinolone-4 hybrids (up 95%).

Язык: Английский

Advances in gold catalyzed synthesis of quinoid heteroaryls DOI Creative Commons

Adnan Majeed,

Ayesha Zafar,

Zanira Mushtaq

и другие.

RSC Advances, Год журнала: 2024, Номер 14(29), С. 21047 - 21064

Опубликована: Янв. 1, 2024

Synthesis of quinoid heteroaryls via gold-catalyzed cascade protocols: recent advances and methodologies.

Язык: Английский

Процитировано

8
One-Pot Synthesis of N-Fused Quinolone-4 Tetracyclic Scaffolds from 2,2-Disubstituted Indolin-3-ones DOI Creative Commons
Nikolai A. Arutiunov, Anna M. Zatsepilina, Anna A. Aksenova

и другие.

ACS Omega, Год журнала: 2024, Номер 9(45), С. 45501 - 45517

Опубликована: Окт. 29, 2024

A cascade transformation of C2-quaternary indoxyls leading to an efficient assembly complex (dihydro)indolo[1,2-a]quinolin-5-one ring systems is reported. The method involves the gram-scale preparation 2-(2-aryl-3-oxoindolin-2-yl)-2-phenylacetonitriles which are then converted with methyl ketones corresponding 2-(2-oxo-2-aryl(alkyl)ethyl)-2-phenylindolin-3-ones. latter can either be isolated good yields (75–96%) or, in case o-nitroacetophenone, used situ for further base-assisted intramolecular SNAr cyclization resulting indoxyl-fused quinolone-4 hybrids (up 95%).

Язык: Английский

Процитировано

2