Perhaloacylation of α-Carbonyl Sulfoxonium Ylides

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 2, 2025

A mild and efficient protocol for the perhaloacylation of α-carbonyl sulfoxonium ylides has been developed. The commercially available perfluoro- perchloroacid anhydrides were used as acylating agents in catalyst- additive-free reactions to access α-carbonyl-α'-perhaloacyl high yields. reaction offers a simple method prepare valuable polyfluorinated organosulfur molecules.

Язык: Английский

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Synthesis of Tris(trifluoromethyl)nickelates(II)—Coping with “The C2F5 Problem”

Inorganics, Год журнала: 2024, Номер 12(7), С. 187 - 187

Опубликована: Июль 5, 2024

When synthesizing the versatile precursors (NMe4)[Ni(CF3)3(MeCN)] we recently encountered problem that marked amounts of C2F5 were incorporated instead CF3 under chosen reaction conditions forming mixed-ligand nickelates [Ni(CF3)x(C2F5)y(MeCN)]− (x + y = 3). We studied three products with 0, 1, or 2, using 19F nuclear magnetic resonance (NMR) spectroscopy and single-crystal X-ray diffraction. able to trace mechanism solve by modifying experimental conditions.

Язык: Английский

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Synthesis of trifluoromethyl substituted heterocyclic compounds with β-trifluoromethylated acrylates

Synthetic Communications, Год журнала: 2024, Номер 54(20), С. 1707 - 1724

Опубликована: Авг. 11, 2024

Trifluoromethyl heterocyclic compounds have high lipophilicity, metabolic stability and binding selectivity, so it is very important to develop their synthetic methods. This review provides an overview of synthesis trifluoromethyl substituted from β-trifluoromethylated acrylates over the period 2018 present.

Язык: Английский

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