EDA Complex-Mediated Aerobic Three-Component CDC Reactions of Quinoxalinones under Visible-Light Irradiation

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Июнь 2, 2025

A visible-light-induced Minisci-type three-component aerobic cross-dehydrogenative coupling (CDC) reaction of quinoxalinones with styrenes and acetophenones is described. The catalytic electron donor-acceptor (EDA) complexation TMSCl found to be the key for oxygen activation, which initiates oxidative radical formation under photocatalyst-free conditions. This protocol provides facile efficient access structurally valuable highly functionalized generally high chemoselectivity moderate good yields.

Язык: Английский

Synthesis of Alkyl Bis(trifluoromethyl)carbinols via Fe-LMCT-Enabled Hydrobis(trifluoromethyl)carbinolation of Alkenes

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Окт. 30, 2024

Bis(trifluoromethyl)carbinols are valuable pharmacophores, yet their synthesis is challenging, largely due to a scarcity of safe and effective bis(trifluoromethyl)carbinolation reagents. Here, we realized the hydrobis(trifluoromethyl)carbinolation alkenes, utilizing stable readily accessible 2,2-bis(trifluoromethyl)glycolic acid as source both bis(trifluoromethyl)carbinol unit hydrogen atom. This process leverages photoinduced Fe-LMCT-enabled radical decarboxylation that generates key intermediate. Our mild protocol facilitates diverse range alkyl bis(trifluoromethyl)carbinols, including structurally complex molecules with pharmaceutical relevance.

Язык: Английский