Programmable Strategies for the Conversion of Aldehydes to Unsymmetrical (Deuterated) Diarylmethanes and Diarylketones DOI Creative Commons
Vipin R. Gavit, Nicole Hanania, Nadim Eghbarieh

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 28, 2025

Herein, we present a versatile method for synthesizing unsymmetrical diarylmethanes and diarylketones from aldehydes arenes. This involves: (1) regioselective Ar-H alkylation to form benzhydrylphosphonium salts via one-pot, four-component reaction with simple reagents (2) chemoselective reductions or oxidations of the benzylic C-P bond. Notably, D2O yield fully deuterated diarylmethanes. high-yielding, straightforward approach offers valuable building blocks enables novel transformations academic pharmaceutical research.

Язык: Английский

Programmable Strategies for the Conversion of Aldehydes to Unsymmetrical (Deuterated) Diarylmethanes and Diarylketones DOI Creative Commons
Vipin R. Gavit, Nicole Hanania, Nadim Eghbarieh

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 28, 2025

Herein, we present a versatile method for synthesizing unsymmetrical diarylmethanes and diarylketones from aldehydes arenes. This involves: (1) regioselective Ar-H alkylation to form benzhydrylphosphonium salts via one-pot, four-component reaction with simple reagents (2) chemoselective reductions or oxidations of the benzylic C-P bond. Notably, D2O yield fully deuterated diarylmethanes. high-yielding, straightforward approach offers valuable building blocks enables novel transformations academic pharmaceutical research.

Язык: Английский

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