Ligand-Controlled Preparation of Aryl-Substituted Allenes Enabled by Nickel-Catalyzed Reductive Coupling of Secondary Propargylic Carbonates with Aryl Halides DOI
Ruotong Li, Jie Hu,

Yonghao Xi

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Herein, we developed a new method for the synthesis of aryl-substituted allenes through nickel-catalyzed reductive coupling reaction between secondary propargyl carbonates and aryl halides. By employing dimethyl-1,10-phenanthroline ligand, achieved ligand-controlled, regioselective arylation, overcoming structural limitations electrophiles. Notably, this exhibits exceptional functional group compatibility, rendering it particularly suitable late-stage allenylation modifications complex molecules.

Язык: Английский

Ligand-Controlled Preparation of Aryl-Substituted Allenes Enabled by Nickel-Catalyzed Reductive Coupling of Secondary Propargylic Carbonates with Aryl Halides DOI
Ruotong Li, Jie Hu,

Yonghao Xi

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Herein, we developed a new method for the synthesis of aryl-substituted allenes through nickel-catalyzed reductive coupling reaction between secondary propargyl carbonates and aryl halides. By employing dimethyl-1,10-phenanthroline ligand, achieved ligand-controlled, regioselective arylation, overcoming structural limitations electrophiles. Notably, this exhibits exceptional functional group compatibility, rendering it particularly suitable late-stage allenylation modifications complex molecules.

Язык: Английский

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