International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(13), С. 7292 - 7292
Опубликована: Июнь 30, 2022
Differential
evolution
of
apoptosis,
programmed
necrosis,
and
autophagy,
parthanatos
is
a
form
cell
death
mediated
by
poly(ADP-ribose)
polymerase
1
(PARP1),
which
caused
DNA
damage.
PARP1
hyper-activation
stimulates
apoptosis-inducing
factor
(AIF)
nucleus
translocation,
accelerates
nicotinamide
adenine
dinucleotide
(NAD+)
adenosine
triphosphate
(ATP)
depletion,
leading
to
fragmentation.
The
mechanisms
mainly
include
damage,
hyper-activation,
PAR
accumulation,
NAD+
ATP
AIF
translocation.
Now,
it
reported
that
widely
exists
in
different
diseases
(tumors,
retinal
diseases,
neurological
diabetes,
renal
cardiovascular
ischemia-reperfusion
injury...).
Excessive
or
defective
contributes
pathological
damage;
therefore,
critical
the
therapy
prevention
many
diseases.
In
this
work,
hallmarks
molecular
its
related
disorders
are
summarized.
questions
raised
recent
findings
also
presented.
Further
understanding
will
provide
new
treatment
option
for
associated
conditions.
Biomedicines,
Год журнала:
2021,
Номер
9(10), С. 1353 - 1353
Опубликована: Сен. 29, 2021
Cancer
is
one
of
the
leading
causes
death
globally.
The
development
drug
resistance
main
contributor
to
cancer-related
mortality.
cells
exploit
multiple
mechanisms
reduce
therapeutic
effects
anticancer
drugs,
thereby
causing
chemotherapy
failure.
Natural
products
are
accessible,
inexpensive,
and
less
toxic
sources
chemotherapeutic
agents.
Additionally,
they
have
action
inhibit
various
targets
involved
in
resistance.
In
this
review,
we
summarized
basic
research
clinical
applications
natural
as
possible
inhibitors
for
cancer.
molecular
each
product
also
explained.
Diverse
biomarkers
were
sensitive
products.
P-glycoprotein
breast
cancer
protein
can
be
targeted
by
a
large
number
On
other
hand,
kinase
C
topoisomerases
most
studied
studies
discussed
review
will
provide
solid
ground
scientists
explore
use
combination
therapies
overcome
targeting
mechanisms.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(20), С. 11128 - 11128
Опубликована: Окт. 15, 2021
One
of
the
most
common
chronic
liver
disorders,
affecting
mainly
people
in
Western
countries,
is
nonalcoholic
fatty
disease
(NAFLD).
Unfortunately,
its
pathophysiological
mechanism
not
fully
understood,
and
no
dedicated
treatment
available.
Simple
steatosis
can
lead
to
steatohepatitis
even
fibrosis,
cancer,
cirrhosis
liver.
NAFLD
very
often
occurs
parallel
with
type
2
diabetes
mellitus
obese
people.
Furthermore,
it
much
more
likely
develop
patients
metabolic
syndrome
(MS),
whose
criteria
include
abdominal
obesity,
elevated
blood
triacylglycerol
level,
reduced
high-density
lipoprotein
cholesterol
increased
pressure,
high
fasting
glucose.
An
important
phenomenon
MS
also
insulin
resistance
(IR),
which
NAFLD.
Liver
IR
development
are
linked
through
an
interaction
between
accumulation
free
acids,
hepatic
inflammation,
oxidative
stress.
The
particularly
exposed
levels
reactive
oxygen
species
due
a
large
number
mitochondria
hepatocytes.
In
these
organelles,
main
DNA
repair
pathway
base
excision
(BER).
present
article
will
illustrate
how
impairment
BER
may
be
related
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(13), С. 7292 - 7292
Опубликована: Июнь 30, 2022
Differential
evolution
of
apoptosis,
programmed
necrosis,
and
autophagy,
parthanatos
is
a
form
cell
death
mediated
by
poly(ADP-ribose)
polymerase
1
(PARP1),
which
caused
DNA
damage.
PARP1
hyper-activation
stimulates
apoptosis-inducing
factor
(AIF)
nucleus
translocation,
accelerates
nicotinamide
adenine
dinucleotide
(NAD+)
adenosine
triphosphate
(ATP)
depletion,
leading
to
fragmentation.
The
mechanisms
mainly
include
damage,
hyper-activation,
PAR
accumulation,
NAD+
ATP
AIF
translocation.
Now,
it
reported
that
widely
exists
in
different
diseases
(tumors,
retinal
diseases,
neurological
diabetes,
renal
cardiovascular
ischemia-reperfusion
injury...).
Excessive
or
defective
contributes
pathological
damage;
therefore,
critical
the
therapy
prevention
many
diseases.
In
this
work,
hallmarks
molecular
its
related
disorders
are
summarized.
questions
raised
recent
findings
also
presented.
Further
understanding
will
provide
new
treatment
option
for
associated
conditions.
