Synapse Editora eBooks, Год журнала: 2023, Номер unknown, С. 93 - 111
Опубликована: Янв. 1, 2023
Reviews in Inorganic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 16, 2025
Abstract Water is a basic unit for survival of living creature and over the past few years, increased industrialization urbanization caused huge contamination natural water resources. Major contaminants are pharmacological-wastes, especially antibiotics from hospitals pharmaceutical industries which causes pollution. Pharmacological elimination ecosystem very critical environmental challenge because they persistent cause potential health hazards. Owing to high surface area, tunable-porosity, versatile functionality Metal-Organic Frameworks (MOFs), their composites have emerged as promising materials purification. Various including amoxicillin, doxycycline, levofloxacin, ciprofloxacin successfully removed wastewater using MOFs composites, purifies by adsorption-mechanism. This study reviews advanced progressions in application MOF-based adsorption pollutants. Additionally, plant-based been explored eco-friendly cost-effective pollutant removal. Despite these advancements, challenges such scalability MOF synthesis, stability under operational conditions, toxicity need be addressed commercial application. Future research should focus on optimizing synthesis processes, enhancing recyclability MOFs, conducting long-term environmental-impact assessments ensure sustainable effective treatment solutions.
Язык: Английский
Процитировано
4
Current Pollution Reports, Год журнала: 2023, Номер 9(3), С. 391 - 409
Опубликована: Май 17, 2023
Язык: Английский
Процитировано
18
Groundwater for Sustainable Development, Год журнала: 2024, Номер 25, С. 101103 - 101103
Опубликована: Янв. 22, 2024
Язык: Английский
Процитировано
4
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Май 21, 2025
This study examines the synthesis and biological evaluation of novel tetrazole derivatives 3,3'-dimethoxybenzidine as potential anticancer agents, focusing on their cytotoxic, apoptotic, anti-inflammatory properties. Ten were synthesized using thioureas precursors, characterized through spectroscopic methods, assessed for in silico toxicological profiles ADMET-AI ProTox 3.0 platforms. In vitro cytotoxic activity was evaluated against four human cancer cell lines (HTB-140, A549, HeLa, SW620) one normal line (HaCaT) MTT LDH assays. Mechanistic studies included apoptosis assessment via flow cytometry interleukin-6 (IL-6) analysis ELISA. The demonstrated significant potential, exhibiting selective cytotoxicity lines, robust induction apoptosis, a notable reduction IL-6 levels. Their favorable toxicity profiles, observed both evaluations, support promising candidates further development. tested compounds showed strong inhibitory regulator Bcl-2, with binding affinities comparable to those native ligands. Western blot revealed dramatic loss Bcl-2 protein expression selected cells during exposure compound 5. Additionally, this research highlights innovative use hazardous substrates drug discovery, aligning principles green chemistry. Future efforts should focus optimizing most active conducting vivo confirm therapeutic safety.
Язык: Английский
Процитировано
0
Analytical Chemistry Letters, Год журнала: 2023, Номер 13(2), С. 127 - 140
Опубликована: Март 4, 2023
Increased demand for water reuse, recycling and reclamation heightens the need improvements in design of wastewater treatment plants that minimize or remove toxic pollutants their metabolites. In this study, solid-phase extraction (SPE) technique utilizing C-18 cartridge was used separation three commonly pharmaceuticals, namely, carbamazepine (CBZ), diclofenac (DF), ketoprofen (KT) samples. High performance liquid chromatography-photodiode array detector (HPLC-PDA) method detection CBZ, DF, KT along stages (aeration, clarifier, raw activated sludge (RAS), chlorine contact chamber (CCC), sulfur dioxide chamber) from Nacogdoches plant (NWWTP), East Texas, USA. Highest concentrations were found RAS followed by influent aeration stage. Pharmaceutical detected samples 2.115 × 10−3 mg/L, 8.95 10−4 mg/L 8.55 respectively. total pharmaceuticals were: (1.285 – 2.117 μg/L), (0.600 0.865 (0.815 0.885 μg/L). The calculated % removal efficiencies follow order; CBZ: > SO2 clarifier ≈ CCC; KT: CCC clarifier; DF: SO2. Determined order (∼ 39.2%) 30.6%) (∼8.8%). Removal NWWTP may be affected human body, transition through processes, metabolism and/or usage humans.
Язык: Английский
Процитировано
4
Cell Biochemistry and Function, Год журнала: 2024, Номер 42(2)
Опубликована: Фев. 13, 2024
Abstract Melanoma, an invasive class of skin cancer, originates from mutations in melanocytes, the pigment‐producing cells. Globally, approximately 132,000 new cases are reported each year, and South Africa, incidence stands at 2.7 per 100,000 people, signifying a worrisome surge melanoma rates. Therefore, there is need to explore treatment modalities that will target melanoma's signalling pathways. Melanoma metastasis aided by ligand activity transforming growth factor‐beta 1 (TGF‐β1), vascular endothelial factor‐C (VEGF‐C) C‐X‐C chemokine 12 (CXCL12) which bind their receptors promote tumour cell survival, lymphangiogenesis chemotaxis. (3‐(4‐dimethylaminonaphthelen‐1‐ylmethylene)‐1,3‐dihydroindol‐2‐one) MAZ‐51 indolinone‐based molecule inhibits VEGF‐C induced phosphorylation factor receptor 3 (VEGFR‐3). Despite successful use conventional cancer therapies, patients endure adverse side effects drug resistance. Moreover, therapies toxic environment caregivers. The medicinal plants phytochemical constituents strategies has become more widespread because rise resistance development unfavourable effects. Zingerone, derived ginger exhibits various pharmacological properties positioning it as promising candidate for treatment. This review provides overview biology intracellular pathways promoting proliferation adhesion. There align health environmental objectives within sustainable goals (good well‐being), 13 (climate action) 15 (life on land) early detection enhance sun‐safe practices, mitigation factors advancing preservation biodiversity, including plants. Thus, this discusses impact cytostatic drugs examines potential phytochemicals adjuvant therapy.
Язык: Английский
Процитировано
1
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(36), С. 47713 - 47723
Опубликована: Авг. 27, 2024
The extensive use of insecticides, such as pyrethroids, and pharmaceutical drugs, doxorubicin (DOX) has significantly increased to meet the growing demand for food production disease treatment. Among them, 3-phenoxybenzoic acid (3-PBA), a metabolite pyrethroid poses various health environmental risks. Similarly, DOX is well-known anticancer drug been continuously used many years. high unregulated disposal these substances raise concerns both humans environment. To address this issue, there pressing need monitor presence analytes in wastewater protect our ecosystems. This challenge inspired us develop an MOF-based fluorometric dual sensor capable rapid selective detection aqueous solutions. work represents first probe detecting targeted analytes. There was 98% fluorescence quenching upon introduction whereas about 11-fold increment probe's intensity took place 3-PBA. sensitivity notably limits (LOD) are 8.7 nM 1.2 Our designed highest
Язык: Английский
Процитировано
1
Green Analytical Chemistry, Год журнала: 2024, Номер 11, С. 100162 - 100162
Опубликована: Окт. 11, 2024
Язык: Английский
Процитировано
1
Synapse Editora eBooks, Год журнала: 2023, Номер unknown, С. 148 - 168
Опубликована: Янв. 1, 2023
Процитировано
1
Environmental Pollution, Год журнала: 2024, Номер 363, С. 125135 - 125135
Опубликована: Окт. 18, 2024
Nowadays, aquatic species face a variety of environmental risks associated with pharmaceutical consumption. More specifically, the increased number cancer patients has been accompanied by an consumption antineoplastic drugs, such as ifosfamide (IF) and cyclophosphamide (CP). These drugs have found in ecosystems, raising concerns about their impact, especially on estuarine species, marine waters are final recipients continental effluents. Simultaneously, predicted climatic changes, salinity shifts, may threaten organisms. Considering this, present research aims to investigate combined effects IF CP, shifts. For transcriptomic, biochemical, histopathological assessment was made using bivalve Mytilus galloprovincialis exposed for 28 days CP (500 ng/L), individually, at different levels (20, 30, 40). up-regulated metabolism-related gene cyp3a1, also affecting abcc gene, showing minimal impact highlighting importance these metabolic routes mussels. Salinity shifts affected transcription genes related apoptosis cell cycle growth, p53, well aerobic metabolism, antioxidant biotransformation mechanisms. findings indicate mussels' high adaptability osmotic stress. Under exposure low salinity, mussels exhibited cellular damage digestive gland tubules, revealing detrimental towards M. galloprovincialis, suggesting that slowdown activation mechanisms helped prevent oxidative control salinities. Overall, results reinforce need antineoplastics ecotoxicological risk assessment, under foreseen climate change scenarios.
Язык: Английский
Процитировано
0