Clinical Nutrition, Год журнала: 2024, Номер 44, С. 248 - 258
Опубликована: Дек. 5, 2024
Язык: Английский
Advanced Materials, Год журнала: 2024, Номер 36(21)
Опубликована: Фев. 24, 2024
Engineered bacteria are widely used in cancer treatment because live facultative/obligate anaerobes can selectively proliferate at tumor sites and reach hypoxic regions, thereby causing nutritional competition, enhancing immune responses, producing anticancer microbial agents situ to suppress growth. Despite the unique advantages of bacteria-based biotherapy, insufficient efficiency limits its application complete ablation malignant tumors. The combination nanomedicine engineered has attracted increasing attention owing their striking synergistic effects treatment. that function as natural vehicles effectively deliver nanomedicines sites. Moreover, provide an opportunity enhance by modulating TME substrates support nanomedicine-mediated reactions. Nanomedicine exhibits excellent optical, magnetic, acoustic, catalytic properties, plays important role promoting bacteria-mediated biotherapies. therapy comprehensively summarized this review. Attention is paid not only fabrication nanobiohybrid composites, but also interpromotion mechanism between therapy. Additionally, recent advances bacteria-synergized multimodal therapies highlighted.
Язык: Английский
Процитировано
15
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2370 - 2370
Опубликована: Фев. 17, 2024
Cannabidiol (CBD), a non-psychoactive phytocannabinoid abundant in Cannabis sativa, has gained considerable attention for its anti-inflammatory, antioxidant, analgesic, and neuroprotective properties. It exhibits the potential to prevent or slow progression of various diseases, ranging from malignant tumors viral infections neurodegenerative disorders ischemic diseases. Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty (NAFLD), alcoholic disease, hepatitis stand prominent causes morbidity mortality chronic diseases globally. The literature substantiated CBD’s therapeutic effects across diverse vivo vitro models. However, precise mechanism action remains elusive, an absence evidence hinders translation into clinical practice. This comprehensive review emphasizes wealth data linking CBD Importantly, we delve detailed discussion receptors through which might exert effects, including cannabinoid receptors, CB1 CB2, peroxisome proliferator-activated (PPARs), G protein-coupled receptor 55 (GPR55), transient channels (TRPs), their intricate connections with In conclusion, address new questions that warrant further investigation this evolving field.
Язык: Английский
Процитировано
10
International Immunopharmacology, Год журнала: 2025, Номер 150, С. 114243 - 114243
Опубликована: Фев. 11, 2025
Язык: Английский
Процитировано
1
Exploration, Год журнала: 2023, Номер 3(5)
Опубликована: Июль 12, 2023
Abstract In recent years, cannabidiol (CBD), a non‐psychotropic cannabinoid, has garnered substantial interest in drug development due to its broad pharmacological activity and multi‐target effects. Diabetes is chronic metabolic disease that can damage multiple organs the body, leading of complications such as abnormal kidney function, vision loss, neuropathy, cardiovascular disease. CBD demonstrated significant therapeutic potential treating diabetes mellitus owing various This work summarizes role impact on dysfunction, nephropathy, retinopathy, neuropathy. Strategies for discovering molecular targets treatment are also proposed. Moreover, ways optimize structure based known generate new analogues explored.
Язык: Английский
Процитировано
17
Biomedicines, Год журнала: 2024, Номер 12(7), С. 1442 - 1442
Опубликована: Июнь 28, 2024
In this study, we investigated in detail the role of cannabidiol (CBD), beta-caryophyllene (BC), or their combinations diabetic peripheral neuropathy (DN). The key factors that contribute to DN include mitochondrial dysfunction, inflammation, and oxidative stress.
Язык: Английский
Процитировано
4
Endocrine Journal, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Nerve aberrations and vascular lesions in the distal lower limbs are etiological factors for diabetic foot ulcers (DFUs). This study aimed to understand regulatory mechanism of angiogenesis patients with DFU by examining lncRNA, as well explore effective targets diagnosing treating DFU. The serum levels A1BG-AS1 miR-214-3p predictive power were determined quantitative PCR ROC analysis. correlation clinical characteristics was examined using chi-square tests. risk type 2 diabetes mellitus (T2DM) identified logistic regression model. Furthermore, binding sites determined. Next, interference plasmid inhibitor co-transfected into high glucose-induced cells investigate their effects on expression angiogenesis-related genes cell proliferation. upregulated, whereas downregulated upregulation significantly associated both blood glucose ulcer grades. served a crucial biomarker evaluating occurrence T2DM. Co-transfection experiments revealed that inhibition effectively recovered suppressive gene expression, endothelial differentiation, sponging effect impaired Thus, is potential therapeutic target
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
The leaves of Cannabis sativa L. subspecies variety Hang-Krarok contained at least 29 terpenoid compounds which 12 terpenoids were the major constituents in 27 treatment combinations. monoterpenes α-pinene, β-myrcene, limonene and β-ocimene. sesquiterpenes (E)-α-bergamotene, β-(E)-caryophyllene, (Z,E)-α-farnesene, β-bisabolene, α-bisabolene aromadendrene. However, found C. showed an effect external factors such as cultivation method seasonal variations, along with leaf maturity internal factor. methods evaporative greenhouse, net-greenhouse, outdoor significantly impact key β-myrcene limonene. Principle component analysis reduced dimensionality large dataset to PC1 PC2, independent pattern sesquiterpenoids (PC1) monoterpenoids (PC2) that is affected by factors. Machine learning algorithms used predict optimization this plant based on features for maximizing yield.The ba
Язык: Английский
Процитировано
0
Pharmaceuticals, Год журнала: 2025, Номер 18(4), С. 446 - 446
Опубликована: Март 21, 2025
Background/Objectives: Diabetes mellitus is a growing global health concern, driving the exploration of new therapies like cannabidiol (CBD), which shows potential in improving insulin sensitivity and glycemic control, though its effects on glucose metabolism remain unclear. This study evaluates CBD’s dose-dependent glycemia, insulin, hepatic carbohydrate diabetic rats. Methods: The Oral Glucose Tolerance Test (OGTT) was performed healthy rats to compare intragastric vs. intraperitoneal CBD (0.5, 5, 50 mg/kg). Diabetic were treated with (25, 50, 100 mg/kg) or metformin (70 for 8 days. Blood glucose, lipid profiles, key carbohydrate-metabolizing enzymes analyzed. Results: In OGTT, reduced AUC, mg/kg showing strongest effect, while had no impact. rats, 25 lowered blood but only increased insulin. dose caused greatest reduction moderate rise, effect. At mg/kg, inhibited glucose-6-phosphatase glucose-6-phosphate. further suppressed gluconeogenic enzymes, glycogen phosphorylase liver enhanced glucose-6-phosphate, metabolic effects. hexokinase weaker Metformin improved utilization storage. at triacylglycerols HDL, Conclusions: provides strong evidence antidiabetic potential, especially particularly through modulation tendency regulate levels.
Язык: Английский
Процитировано
0
Molecular Immunology, Год журнала: 2025, Номер 181, С. 129 - 138
Опубликована: Март 26, 2025
Язык: Английский
Процитировано
0
MedComm, Год журнала: 2024, Номер 5(10)
Опубликована: Окт. 1, 2024
Abstract Glycoproteins, representing a significant proportion of posttranslational products, play pivotal roles in various biological processes, such as signal transduction and immune response. Abnormal glycosylation may lead to structural functional changes glycoprotein, which is closely related the occurrence development diseases. Consequently, exploring protein can shed light on mechanisms behind disease manifestation pave way for innovative diagnostic therapeutic strategies. Nonetheless, study clinical glycoproteomics fraught with challenges due low abundance intricate structures glycosylation. Recent advancements mass spectrometry‐based have improved our ability identify abnormal glycoproteins samples. In this review, we aim provide comprehensive overview foundational principles recent glycoproteomic methodologies applications. Furthermore, discussed typical characteristics, underlying functions, diseases, brain cardiovascular cancers, kidney metabolic Additionally, highlighted potential avenues future glycoproteomics. These insights provided review will enhance comprehension methods diseases promote elucidation pathogenesis discovery novel biomarkers targets.
Язык: Английский
Процитировано
3