An oxygen-independent therapeutic nanosystem for fighting against hypoxic and antioxidant microenvironment of tumor

Journal of Photochemistry and Photobiology B Biology, Год журнала: 2025, Номер 268, С. 113184 - 113184

Опубликована: Май 18, 2025

Язык: Английский

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Research advances of PANoptosis in gastrointestinal tumors

International Immunopharmacology, Год журнала: 2025, Номер 159, С. 114931 - 114931

Опубликована: Май 24, 2025

Язык: Английский

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Two‐Dimensional Atomically Thin Piezoelectric Nanosheets for Efficient Pyroptosis‐Dominated Sonopiezoelectric Cancer Therapy

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Сен. 9, 2024

Abstract Sonopiezocatalytic therapy is an emerging therapeutic strategy that utilizes ultrasound irradiation to activate piezoelectric materials, inducing polarization and energy band bending facilitate the generation of reactive oxygen species (ROS). However, efficient ROS hindered by long distance charge migration from bulk material surface. Herein, atomically thin Bi 2 O (OH)(NO 3 ) (AT‐BON) nanosheets are rationally engineered through disrupting weaker hydrogen bonds within [OH] [NO ] layer in material. The ultrathin structure AT‐BON piezocatalytic shortens carriers, expands specific surface area, accelerates transfer efficiency, showcasing a natural advantage generation. Importantly, non‐centrosymmetric polar crystal grants ability separate electron‐hole pairs. Under ultrasonic mechanical stress, with remarkable feature exhibit desirable vivo antineoplastic outcomes both breast cancer model liver model. Especially, AT‐BON‐induced bursts lead activation Caspase‐1‐driven pyroptosis pathway. This study highlights beneficial impact thinning on enhancing efficiency anti‐cancer effects.

Язык: Английский

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Two-Dimensional Biodegradable l-Cysteine-Iodine Nanosheets for Computed Tomography-Guided Cancer Synergistic Sonodynamic Therapy and Chemotherapy

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(42), С. 56696 - 56704

Опубликована: Окт. 8, 2024

Biodegradable versatile inorganic nanomaterials are highly desirable in the field of nanomedicine. Here, for first time, we report a kind novel two-dimensional biodegradable l-cysteine-iodine (l-Cys-I) nanosheet with high computed tomography (CT) imaging ability and sonosensitization efficacy. Such l-Cys-I nanosheets consist iodine molecules l-Cys, where coordinated stabilized by l-Cys cross-linked to form through disulfide bonds. The large convenient functional surface is further modified targeting moieties DSPE-PEG-RGD cancer drug doxorubicin (DOX) construct nanotheranostic nanoplatform (CIRD). Under ultrasound irradiation, CIRD assist tremendous reactive oxygen species generation controllable DOX release, leading remarkable anticancer performance both vitro vivo due synergistic sonodynamic therapy (SDT) chemotherapy. Our results validate that enable effective body excretion negligible systemic toxicity owing biodegradation properties. nanosheets, biodegradability, biocompatibility, versatility, hold great promise nanotheranostics.

Язык: Английский

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Targeting lipid metabolism via nanomedicine: a prospective strategy for cancer therapy

Biomaterials, Год журнала: 2024, Номер 317, С. 123022 - 123022

Опубликована: Дек. 15, 2024

Язык: Английский

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