Ultra-fast re-programmable actuator for use in multiple scenarios

Chemical Engineering Journal, Год журнала: 2025, Номер 508, С. 160978 - 160978

Опубликована: Фев. 24, 2025

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Gold Nanoparticles Modulate Macrophage Polarization to Promote Skeletal Muscle Regeneration

Materials Today Bio, Год журнала: 2025, Номер 32, С. 101653 - 101653

Опубликована: Март 12, 2025

Skeletal muscle regeneration is a complex process that depends on the interplay between immune responses and stem cell (MuSC) activity. Macrophages play crucial role in this process, exhibiting distinct polarization states-M1 (pro-inflammatory) M2 (anti-inflammatory)-that significantly affect tissue repair outcomes. Recent advancements nanomedicine have positioned gold nanoparticles (Au NPs) as promising tools for modulating macrophage enhancing regeneration. This review examines of Au NPs influencing behavior, focusing their physicochemical properties, biocompatibility, mechanisms action. We discuss how can promote polarization, facilitating through modulation cytokine production, interaction with surface receptors, activation intracellular signaling pathways. Additionally, we highlight benefits MuSC function, angiogenesis, extracellular matrix remodeling. Despite potential skeletal regeneration, challenges remain optimizing nanoparticle design, developing targeted delivery systems, understanding long-term effects. Future directions should focus personalized medicine approaches combination therapies to enhance therapeutic efficacy. Ultimately, emphasizes transformative regenerative medicine, offering hope improved treatments injuries diseases.

Язык: Английский

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Preparation of Graphene Oxide/Polymer Hybrid Microcapsules via Photopolymerization for Double Self-Healing Anticorrosion Coatings

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(29), С. 38564 - 38575

Опубликована: Июль 15, 2024

In this work, graphene oxide (GO)/polymer hybrid microcapsule-loaded self-healing agents were prepared via the combination of emulsion template method and photopolymerization technology. The incorporation GO in microcapsule shell not only improved impermeability, mechanical property, solvent resistance property microcapsules significantly but also endowed with photothermal conversion property. By incorporating GO/polymer water-borne epoxy resin, a novel kind anticorrosion coating double was successfully fabricated. When scratched, linseed oil (LO) encapsulated could fill crack, promote molecular chain movement damaged area under near-infrared (NIR) irradiation to realize close crack. Based on filling LO conversion-induced scratch narrowing, "filling" "close" effect can be realized temporal NIR irradiation, which lead complete recovery scratched coating. |

Язык: Английский

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Drug release from docetaxel-entrapped core-crosslinked polymeric micelles: A population pharmacokinetic modelling approach based on clinical data

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 186, С. 118028 - 118028

Опубликована: Апрель 4, 2025

Язык: Английский

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Flexible Sono–Piezo Patch for Functional Sweat Gland Repair through Endogenous Microenvironmental Remodeling

ACS Nano, Год журнала: 2024, Номер 18(31), С. 20283 - 20295

Опубликована: Июль 22, 2024

Remodeling the endogenous regenerative microenvironment in wounds is crucial for achieving scarless, functional tissue regeneration, especially recovery of skin appendages such as sweat glands burn patients. However, current approaches mostly rely on use exogenous materials or chemicals to stimulate cell proliferation and migration, while remodeling a pro-regenerative remains challenging. Herein, we developed flexible sono-piezo patch (fSPP) that aims create an promote repair wounds. This patch, composed multifunctional fibers with embedded piezoelectric nanoparticles, utilized low-intensity pulsed ultrasound (LIPUS) activate electrical stimulation target tissue, resulting enhanced behaviors niche tissues cells, including peripheral nerves, fibroblasts, vasculatures. We further demonstrated effective wound healing regeneration injuries solely through physical stimulation. noninvasive drug-free therapeutic approach holds significant potential clinical treatment injuries.

Язык: Английский

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Rational Design of Quinoidal Conjugated Polymers for Photothermal Antibacterial Therapy

Macromolecular Rapid Communications, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

Abstract The increasing prevalence of antibiotic resistance, driven by the overuse and misuse conventional antibiotics, has become a critical public health concern. Photothermal antibacterial therapy (PTAT) utilizes heat generated photothermal agents under light exposure to inhibit bacterial growth without inducing attracting more attention. Quinoid conjugated polymers, especially para‐azaquinodimethane (AQM) polymer, are class organic semiconductors known for efficient π‐electron delocalization, near‐infrared absorption, narrow bandgap, showing great potential in application reagents. However, current AQM polymers face challenges related their solubility, photostability, biocompability. In this study, tetraglycol is introduced onto core improving drawbacks resulting polymers. Two with different electron donor (thiophene 2,2'‐bithiophene) synthesized evaluated various properties. PAQMT exhibited superior performance, including higher extinction coefficients, improved greater stability repeated NIR irradiation. further developed into nanoparticles via encapsulation, excellent colloidal stability, effective inhibition 808 nm light. This work provides new strategy properties offers opportunities promoting quinoidal PTAT.

Язык: Английский

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External Stimuli-Driven Catalytic Hydrogels for Biomedical Applications

Chemical Communications, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review discusses design strategies for external stimuli-driven hydrogels with in situ catalytic processes. It highlights precise control over the properties, elucidating regulatory mechanisms and deepening understanding of applications.

Язык: Английский

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Ultrasound Activated Piezoelectric Catalysis and Neurogenic Activity for Effective Therapy of MRSA Infected Bone Defects by Phase/Defect‐Engineered Barium Strontium Titanate

Small Methods, Год журнала: 2025, Номер unknown

Опубликована: Фев. 10, 2025

Abstract Infected bone defects are a growing global health issue, with risks including destruction, disability, and even death. The main clinical challenge is the difficulty in simultaneously achieving effective antibacterial action promoting regeneration. Calcination at 800°C induces phase transition from cubic (C‐BSTO) to polarized tetragonal (T‐BSTO), imparting piezoelectric properties. Subsequent treatment sodium borohydride generates oxygen vacancies, enhancing polarization performance. synthesized T‐BSTO‐V o achieves 99.83% efficiency against methicillin‐resistant Staphylococcus aureus (MRSA) under 1.5 W cm² ultrasound (US) irradiation for 20 min. Mild US activates signal, Schwann cell (SC) neurogenic differentiation via PI3K‐AKT signaling intracellular Ca²⁺ elevation. Further studies showed that synergy of neurotransmitter SCs electric signal increased osteogenic human marrow mesenchymal stem cells (BMSCs). Consequently, US‐irradiated effectively promotes innervated regeneration MRSA‐infected defect model through rapidly killing bacteria, modulating immune microenvironment. This study offers new approach developing bioactive sonosensitizers phase/defect engineering, treats enhanced piezocatalytic effect

Язык: Английский

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Inorganic Biomaterials Inducing Scaffolds Pre‐Neuralization for Infarcted Myocardium Repair

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 24, 2025

Abstract Neural networks are found to play an important role in monitoring and coordinating cardiac physiological activities. However, the clinical use of neuroregulatory strategies for repairing infarcted myocardium, such as vagus nerve stimulation pharmacological activation, confronts challenges managing signals potential drug side effects. In this study, innovative myocardial infarction repair strategy by creating a “pre‐neuralized” scaffold that combines strontium silicate microparticles with neural stem cells (NSCs) is introduced. Strontium promotes NSCs differentiation, resulting enriched mature neurons. This exhibits capabilities enhance maturation synchronized contraction cardiomyocytes, facilitating improving function vivo. The findings indicate pre‐neuralized aids recovery modulating genes linked circadian rhythm, underscoring strategic benefit neural‐induced regulation tissue repair. conclusion, study presents promising approach myocardium using inorganic biomaterial‐induced scaffolds neuromodulatory properties from perspective systemically regulation. work may offer new addressing complex organ injuries.

Язык: Английский

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Nanohybrid Uric Oxidase with Magnetically Switchable Catalytic Potential for Precise Gout Therapy

Biomaterials, Год журнала: 2025, Номер unknown, С. 123277 - 123277

Опубликована: Март 1, 2025

Язык: Английский

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