ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 1, 2024
Because
of
their
unique
electromechanical
coupling
response,
piezoelectric
smart
biomaterials
demonstrated
distinctive
capability
toward
effective,
efficient,
and
quick
diagnosis
treatment
a
wide
range
diseases.
Such
materials
have
potentiality
to
be
utilized
as
wireless
therapeutic
methods
with
ultrasonic
stimulation,
which
can
used
self-powered
biomedical
devices.
An
emerging
advancement
in
the
realm
personalized
healthcare
involves
utilization
biosensors
for
such
diverse
physiological
signals
human
body,
viruses,
pathogens,
diseases
like
neurodegenerative
ones,
cancer,
etc.
The
combination
nanoparticles
ultrasound
has
been
established
promising
approach
sonodynamic
therapy
piezocatalytic
therapeutics
provides
appealing
alternatives
noninvasive
treatments
chronic
wounds,
neurological
diseases,
Innovations
implantable
medical
devices
(IMDs),
energy
generator
(iPEG),
offer
significant
advantages
improving
functioning
ability
power
cardiac
pacemaker
restore
heart
function.
This
comprehensive
review
critically
evaluates
role
piezoelectricity
disease
treatment,
highlighting
implication
It
also
discusses
potential
monitoring,
tissue
engineering,
other
applications
while
emphasizing
future
trends
challenges
field.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 2, 2025
Abstract
Eliciting
ferroptotic
cell
death
in
tumors
has
enhanced
prospects
for
cancer
therapy
because
of
its
proinflammatory
properties,
which
enable
damage‐associated
molecular
pattern
(DAMP)
release
and
immune
response
activation.
However,
the
immunogenicity
ferroptosis
how
to
controllably
activate
self‐enhanced
antitumor
by
cellular
require
further
investigation.
In
this
study,
a
piezoelectric
BaTiO
3
‐based
inducer
(BTO@Fe)
is
synthesized
effective
immunotherapy.
BTO@Fe
induces
moderate
introducing
excess
iron
catalyzing
Fenton
reaction.
When
subjected
ultrasound
(US)
irradiation,
piezoelectrically
excited
electrons
holes
are
separated,
reactive
oxygen
species
(ROS)
generation
glutathione
(GSH)
consumption
consequently
causing
intensified
immunogenic
(ICD).
Moreover,
activated
CD8
+
T
cells
respond
signals
releasing
interferon
gamma
(IFNγ),
sensitizes
tumor
an
intrinsic
mechanism
initiation.
The
robust
originating
from
exogenous
piezocatalytic
reactions
endogenous
responses
demonstrates
satisfactory
vitro
vivo
effects.
This
work
suggests
that
doping‐engineered
materials
with
augmented
catalytic
activity
promising
countermeasures
restoring
cells.
ABSTRACT
Metal
surface
coating
modification
is
an
effective
method
to
solve
the
problem
of
corrosion
and
inflammation
in
biometal
clinical
applications.
Hydrogel
currently
a
commonly
used
material.
Because
its
hydrophilicity,
biocompatibility,
good
biomechanical
properties,
hydrogel
widely
Functionalized
coatings
on
surfaces
can
effectively
ameliorate
problems
such
as
corrosion,
late
thrombosis,
inflammation,
other
complications
implanted
metals.
Therefore,
realizing
strong
bond
between
hot
issue.
This
article
centers
bonding
biometal,
focusing
review
(i)
pretreatment
methods,
(ii)
biometal‐hydrogel
(iii)
application
surfaces.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 8309 - 8336
Опубликована: Авг. 1, 2024
The
treatment
of
craniofacial
bone
defects
caused
by
trauma,
tumors,
and
infectious
degenerative
diseases
is
a
significant
issue
in
current
clinical
practice.
Following
the
rapid
development
tissue
engineering
(BTE)
last
decade,
bioactive
scaffolds
coupled
with
multifunctional
properties
are
high
demand
regard
to
effective
therapy
for
defects.
Herein,
an
innovative
scaffold
consisting
GO/Cu
nanoderivatives
GelMA-based
organic-inorganic
hybrids
was
reported
repairing
full-thickness
calvarial
defect.
