Engineered Neutrophil Nanovesicles for Inhibiting Corneal Neovascularization by Synergistic Anti‐Inflammatory, Anti‐VEGF, and Chemoexcited Photodynamic Therapy

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

Corneal neovascularization (CorNV) develops under various pathological conditions and is one of the main causes blindness. Due to that CorNV progression involves multiple steps, anti-vascular endothelial growth factor (VEGF) drugs alone could not sufficiently suppress this process, highlighting an urgent need for efficient delivery system multi-step management CorNV. In study, a neutrophil nanovesicle-based eye drop (NCCR) developed therapy simultaneously inhibits angiogenesis inflammation, while eliminating cells through chemoexcited photodynamic (PDT). NCCR targets inflammatory lesions by leveraging expression chemokine receptors from source cells. Then, exerts inhibitory effects on sequential steps neovascularization. First, it acts as decoy anti-inflammatory effect neutralizing cytokines via its surface nanovesicles. Second, thioketals bond-linked ranibizumab released in high reactive oxygen species microenvironment sites bind VEGF, inhibiting vascular cell activation proliferation. Finally, PDT eliminates preformed corneal blood vessels, disrupting tube formation pericyte recruitment. The synergistic combined with induction apoptosis neovessels PDT, offer novel strategy treatment.

Язык: Английский

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Innovative design of bacterial outer membrane vesicles for vaccine development

Nano Today, Год журнала: 2025, Номер 61, С. 102650 - 102650

Опубликована: Фев. 1, 2025

Язык: Английский

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Injectable mineralized hydrogel microspheres for accelerated osteocyte network reconstruction and intelligent bone regeneration

Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 240 - 255

Опубликована: Фев. 6, 2025

Язык: Английский

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A Novel NIR-dependent IDO-inhibiting Ethosomes Treatment Melanoma through PTT/PDT/Immunotherapy synergy

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 251, С. 114565 - 114565

Опубликована: Фев. 20, 2025

Язык: Английский

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Platelet hitchhiking vascular-disrupting agents for self-amplified tumor-targeting therapy

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 10, 2025

The vascular-disrupting agent DMXAA (5,6-dimethylxanthone-4-acetic acid) exhibits potent anticancer activity by targeting tumor vasculature and activating immune responses via the cGAS-STING pathway. However, its clinical application is hindered nonspecific significant cardiovascular toxicity. This study introduces a novel self-amplified tumor-targeting delivery system(P@NPPD)comprising azide-functionalized poly(ethylene glycol)-b-poly-[(N-2-hydroxyethyl)-aspartamide]-DMXAA (N3-PEG-b-PHEA-DMXAA, NPPD) conjugated to DBCO modified platelets. Among them, NPPD was synthesized conjugating N3-PEG-b-poly-[(N-2-hydroxyethyl)-aspartamide] through esterification. system enhances tumor-specific drug while minimizing systemic Leveraging natural tumor-homing properties of platelets coagulation cascade, P@NPPD selectively targets exposed collagen at sites, initiating self-amplifying release DMXAA. approach achieved 2.61-fold improvement in efficiency an 89.1% suppression rate. In addition improving accumulation significantly activated local responses, enhancing therapeutic efficacy safety. These findings underscore potential as promising platform for cancer therapy.

Язык: Английский

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Overcoming Biological Barriers in Cancer Therapy: Cell Membrane-Based Nanocarrier Strategies for Precision Delivery

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 3113 - 3145

Опубликована: Март 1, 2025

Given the unique capabilities of natural cell membranes, such as prolonged blood circulation and homotypic targeting, extensive research has been devoted to developing membrane-inspired nanocarriers for cancer therapy, while most focused on overcoming one or a few biological barriers. In fact, journey nanosystems from systemic tumor cells involves intricate processes, encompassing circulation, tissue accumulation, endocytosis, endosomal escape, intracellular trafficking target sites, therapeutic action, all which pose limitations their clinical translation. This underscores necessity meticulously considering these barriers in design membrane-mimetic nanocarriers. this review, we delineate functions applications diverse types membranes nanocarrier systems. We elaborate hurdles encountered at each stage biomimetic nanoparticle's odyssey target, comprehensively discuss obstacles imposed by microenvironment precise delivery. Subsequently, systematically review contemporary membrane-based strategies aimed multi-level barriers, hybrid membrane (HCM) camouflage, remodeling, endosomal/lysosomal multidrug resistance (MDR) reversal, optimization nanoparticle physicochemical properties, so on. Finally, outline potential accelerate development precision challenges that must be addressed enhance applicability. serves guide refining study surmounting vivo delivery thereby significantly contributing advancing application nanoparticles

Язык: Английский

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Functionalization of black phosphorus nanoparticles with proteins derived from cancer cells for targeted chemo-photothermal combination therapy against cancer

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2025, Номер unknown, С. 136686 - 136686

Опубликована: Март 1, 2025

Язык: Английский

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Advancing Eco-friendly Biomedicine: Sustainable Nanocomposites as Platforms for Genetic Vaccines

Опубликована: Янв. 1, 2025

Язык: Английский

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Biocompatible lipid nanovehicles for preventive and therapeutic vaccine development

Coordination Chemistry Reviews, Год журнала: 2025, Номер 538, С. 216718 - 216718

Опубликована: Апрель 22, 2025

Язык: Английский

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Nanoarchitecting intelligently encapsulated designs for improved cancer therapy

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Май 1, 2025

Despite the success in exploring various aspects of origination and therapeutic strategies, cancer has remained one most dreadful metabolic disorders due to failure eradicate tumors comprehensively frequent recurrence because acquired resistance drugs. Recently, several advancements have been evidenced fabrication smart nanocarriers encapsulated with multiple components. Several reasons for nanoencapsulation include enhancement bioavailability drugs, precise targetability reduce adverse effects on normal cells, ability enable controlled drug release rates at tumor sites. In addition, these protect cargo from deactivation, responsively delivering it based physiological or pathological characteristics tumors. this review, we present approaches therapy, including organic materials, inorganic components, their composites, as well biomembrane-based strategies. These along practical applications potential treatment, are discussed depth, highlighting advantages disadvantages, aiming reveal ultimate prospects enhancing delivery efficiency targeted therapy.

Язык: Английский

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