Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 8, 2024
Abstract
Mineralization
of
living
cells
represents
an
evolutionary
adaptation
that
enhances
cellular
resilience
to
physicochemical
stress.
Inspired
by
this
strategy,
we
have
here
developed
hybrid
materials
(HLMs),
incorporating
probiotics
into
mineralized
collagen
3D
matrices,
with
the
aim
protecting
and
promoting
successful
oral
delivery
bacteria.
Collagen
fibrils
are
simultaneously
self‐assembled
in
presence
(
Lactobacillus
acidophilus
,
La
was
used
as
model),
resulting
integration
matrix
(i.e.,
bulk
encapsulation).
During
process,
also
coated
a
nanofilm
apatite
mineral
(single‐cell
encapsulation),
which
provides
them
extra
protection
reinforces
their
viability
activity.
In
fact,
HLM
is
metabolically
active,
maintain
capacity
ferment
milk
yogurt
antibacterial
activity
against
two
major
foodborne
pathogens
Pseudomonas
aeruginosa
(Pa)
Staphylococcus
aureus
(Sa)
.
Interestingly,
additional
gastrointestinal
environment
simulated
gastric
fluid),
special
interest
for
healthcare
administration.
The
results
pave
way
creation
innovative
enhanced
functionalities
potential
produce
probiotic
foods
notable
antimicrobial
properties.
Designed Monomers & Polymers,
Год журнала:
2024,
Номер
28(1), С. 1 - 34
Опубликована: Дек. 31, 2024
This
review
paper
analyzes
recent
advancements
in
bio-polymer
coatings
for
probiotic
microencapsulation,
with
a
particular
emphasis
on
chitosan
and
its
synergistic
combinations
other
materials.
Probiotic
microencapsulation
is
essential
protecting
probiotics
from
environmental
stresses,
enhancing
their
stability,
ensuring
effective
delivery
to
the
gut.
The
begins
an
overview
of
highlighting
significance
safeguarding
through
processing,
storage,
gastrointestinal
transit.
Advances
chitosan-based
encapsulation
are
explored,
including
integration
bio-polymers
such
as
alginate,
gelatin,
pectin,
well
application
nanotechnology
innovative
techniques
like
spray
drying
layer-by-layer
assembly.
Detailed
mechanistic
insights
integrated,
illustrating
how
influences
gut
microbiota
by
promoting
beneficial
bacteria
suppressing
pathogens,
thus
role
prebiotic
or
synbiotic.
Furthermore,
delves
into
chitosan's
immunomodulatory
effects,
particularly
context
inflammatory
bowel
disease
(IBD)
autoimmune
diseases,
describing
immune
signaling
pathways
influenced
linking
changes
improvements
systemic
immunity.
Recent
clinical
trials
human
studies
assessing
efficacy
chitosan-coated
presented,
alongside
discussion
practical
applications
comparison
vitro
vivo
findings
highlight
real-world
relevance.
sustainability
sources
impact
addressed,
along
novel
concept
gut-brain
axis.
Finally,
emphasizes
future
research
needs,
development
personalized
therapies
exploration
techniques.
Food systems,
Год журнала:
2025,
Номер
7(4), С. 598 - 604
Опубликована: Фев. 3, 2025
Beverages
are
among
the
most
popular
types
of
products
that
attract
attention
researchers
for
enrichment
with
functional
ingredients.
The
introduction
probiotics
into
food
matrix
can
increase
usefulness
products,
including
beverages.
However,
extremely
sensitive
to
extreme
environmental
conditions,
which
significantly
limits
their
ability
survive
in
food.
aim
research
is
establish
an
effect
encapsulation
on
preservation
bifidobacteria
enriched
juice-containing
beverage.
Capsules
from
sodium
alginate
were
used
protect
probiotic
microorganisms
(bifidobacteria
six
strains
symbiotic
starter)
unfavorable
conditions
environment
system
and
gastrointestinal
tract.
capsules
obtained
by
drip
method.
stability
was
determined
under
different
conditions.
Their
solubility
water
at
pH
values
typical
stomach
(1.1–1.6),
small
intestine
(7.8–8.2),
large
(8.0–8.5)
studied.
tests
carried
out
upon
keeping
buffer
solutions
15
30
min.
In
addition,
apple
juice
a
3.82
when
stored
4±1°C
7,
14,
21,
28
days
assessed.
Capsule
losses
during
heat
treatment
analyzed.
amount
extracted
after
mechanical
destruction
subsequent
inoculation
GMK1
medium
also
monitored
storage.
results
studies
showed
greatest
destructive
observed
acidic
stomach,
where
amounted
47.4%
parts
ranged
25.3
30.9%.
selected
system,
juice,
turned
be
less
aggressive
capsules,
8.7%
pasteurization
modes
60.17%
processing
10
minutes
85°C
67.42%
98°C.
differences
statistically
significant
(p≤0.05).
Thus,
using
data,
it
possible
predict
total
loss
digestion
storage
product
inoculate
required
impart
properties
product.
has
development
prospects
taking
account
possibility
varying
taste
aroma
both
capsules.
Journal of Multidisciplinary Healthcare,
Год журнала:
2025,
Номер
Volume 18, С. 1493 - 1510
Опубликована: Март 1, 2025
Abstract:
This
review
explores
the
multifaceted
roles
and
applications
of
probiotics,
emphasizing
their
significance
in
maintaining
enhancing
host
health
through
microbial
interactions.
It
includes
concept
holobionts
symbiotic
relationships
between
hosts
microbiomes,
illustrating
how
various
microbiota
can
enhance
immunity,
support
growth,
prevent
diseases.
delves
into
customization
probiotics
using
molecular
genomic
techniques,
focusing
Enterococcus,
Bifidobacterium
,
Lactobacillus
species.
Furthermore,
it
discusses
effects
symbiotics
which
aids
survivability
beneficial
probiotics.
The
role
microbes
gut
is
emphasized,
noting
its
impact
on
preventing
diseases
a
stable
community.
potential
therapeutic
value
ability
to
treat
gastrointestinal
diseases,
as
well
strengthen
immune
system
reduce
number
free
radicals
that
are
present
body.
Additionally,
secondary
metabolites
produced
by
bacteria
gut,
such
bacteriocins
exopolysaccharides,
effect
human,
particularly
tract.
concludes
addressing
use
traditional
medicine
novel
applications,
including
treatment
endangered
wildlife
species
human
ailments.
Keywords:
health,
microbiota,
metabolites,
synergistic
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 31, 2025
The
encapsulation
of
bacteria
in
metal–organic
frameworks
(MOFs)
is
being
studied
for
use
biomedicine
and
bioremediation.
However,
biocompatibility
could
be
improved,
as
much
the
research
focuses
on
ZIF-8
Escherichia
coli.
MIL-88A,
composed
fumaric
acid
iron,
offers
a
safer
alternative.
This
study
investigates
probiotic
strain
Lactiplantibacillus
plantarum
299v
nanocrystalline
matrix
via
simple
one-pot
synthesis.
encapsulated
show
improved
stability
saline,
lysozyme
pepsin
compared
to
uncoated
cells.
These
findings
highlight
potential
iron(III)
fumarate
bacterial
protection
controlled
release
biological
applications.
Annals of the New York Academy of Sciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 5, 2025
Abstract
The
human
gut
microbiome
is
a
complex
ecosystem
that
plays
vital
role
in
maintaining
health
and
contributing
to
the
pathogenesis
of
various
diseases.
This
review
proposes
transformative
approach
involves
engineering
artificial
microbial
consortia—precisely
designed
communities
microorganisms—for
personalized
modulation
targeted
therapeutic
interventions.
By
integrating
synthetic
biology,
systems
advanced
culturing
techniques,
tailored
consortia
can
be
developed
perform
specific
functions
within
gut,
including
production
molecules,
immune
responses,
competition
against
pathogenic
bacteria.
In
vitro
vivo
studies
indicate
these
engineered
effectively
restore
balance
enhance
host
resilience.
holds
immense
potential
revolutionize
healthcare
by
addressing
root
causes
diseases
such
as
metabolic
disorders,
inflammatory
conditions,
gastrointestinal
infections
through
precise
manipulation
microbiome.
Future
research
should
focus
on
rigorous
clinical
trials
evaluate
safety,
efficacy,
long‐term
impacts
diverse
populations,
paving
way
for
innovative
therapies
promote
overall
well‐being.
