Current Green Chemistry,
Год журнала:
2024,
Номер
11(4), С. 351 - 368
Опубликована: Апрель 16, 2024
:
Aspergillus
sp.,
a
ubiquitous
filamentous
fungus,
poses
significant
challenges
to
the
food
industry
as
common
spoilage
and
mycotoxin
producing
organism.
The
conventional
use
of
chemical
preservatives
control
contamination
raises
concerns
about
potential
health
risks
environmental
impacts.
Therefore,
alternative
approaches,
such
utilization
natural
biopreservatives,
inexpensive,
safe,
promising
decontamination
strategies
are
being
explored.
Lactic
acid
bacteria
have
gained
considerable
attention
candidates
due
their
antimicrobial
properties
long-standing
safe
in
fermentation.
This
review
provides
thorough
summary
lactic
biopreservatives
against
sp.
inhibitory
mechanisms
proliferation
yield
explored,
highlighting
role
organic
acids,
peptides,
other
bioactive
compounds.
versatile
application
based
across
range
matrices,
storage
conditions,
etc.
is
also
addressed.
Further
research
warranted
optimize
strains,
explore
synergistic
combinations,
investigate
efficacy
real
systems.
Implementing
biopreservative
could
significantly
enhance
safety
quality
by
reducing
risks.
Toxicology Reports,
Год журнала:
2025,
Номер
14, С. 101952 - 101952
Опубликована: Фев. 7, 2025
A
comprehensive
overview
of
food
mycotoxins,
their
toxicity,
and
contemporary
detoxification
techniques
is
given
in
this
article.
Mycotoxins,
which
are
harmful
secondary
metabolites
generated
by
a
variety
fungi,
including
Fusarium,
Aspergillus,
Penicillium,
provide
serious
health
concerns
to
humans
animals.
These
include
hepatotoxicity,
neurotoxicity,
carcinogenicity.
Mycotoxins
commonly
found
basic
products,
as
evidenced
recent
studies,
raising
worries
about
public
safety.
The
article
discusses
detection
such
enzyme-linked
immunosorbent
assays
(ELISA),
quick
strip
tests.
Moreover,
the
use
various
control
systems
associated
with
mycotoxinis
highlighted.
In
addition,
novel
strategies
nanotechnology,
plant
extracts,
omics
studies
were
also
discussed.
When
taken
whole,
analysis
helps
clarify
pressing
need
for
efficient
management
monitoring
prevent
mycotoxin
contamination
chain.
IntechOpen eBooks,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 10, 2025
Aflatoxins
(AFs)
are
secondary
metabolites
produced
by
Aspergillus
section
Flavi,
mainly
flavus
and
parasiticus.
These
species
may
infect
food
feed
along
entire
agri-food
chains,
synthesizing
the
toxin
when
environmental
conditions
favorable.
The
scenario
of
climate
change
that
world
will
have
to
face
in
next
decades
is
expected
increase
levels
AF
contamination
cereals,
nuts,
spices,
legumes,
among
other
important
crops
around
world.
This
situation
a
great
impact
on
human
animal
health,
as
well
economic
losses
due
rejection
contaminated
products
during
commercialization.
Several
mitigation
strategies
been
implemented
counteract
this
problem.
Some
them
intended
prevent
synthesis,
while
others
designed
decontaminate
pre-formed
toxin.
In
addition,
several
pre-
post-harvest
shown
effectivity.
Besides
physical
chemical
tools,
biological
control
based
different
microorganisms
use
enzymes
proposed
promissory
approaches
mitigate
risk
contamination.
chapter,
detailed
information
about
two
developments
presented:
biocontrol
prevention
non-toxigenic
A.
strain
fungal
laccases
AFs.
integration
these
tools
enhance
quality
feed,
contributing
safety
chains.
Abstract
This
study
investigates
the
proximate
composition,
aflatoxin
contamination,
and
their
implications
on
health
wellbeing
of
broilers
layers,
as
well
comparison
from
two
poultry
feed
manufacturing
companies
(C1
C2)
located
in
Jos
Kaduna,
Nigeria.
A
total
168
samples
were
collected
four
types
(starters,
finishers,
chicks,
growers)
these
companies.
Samples
ground,
sieved,
analyzed
for
moisture,
protein,
fat,
ash,
fiber,
carbohydrate,
energy,
content
using
standard
methods.
Proximate
analysis
results
revealed
significant
differences
nutritional
components
between
locations.
In
C1,
moisture
ranged
8
to
18%,
while
C2,
where
levels
17%.
The
protein
C1
C2
14.5%
24%
~
25%.
Fat
was
similar
both
(5%–8%)
ash
(5%–8%).
Carbohydrate
46
62%
46%
60.8%
C2.
Aflatoxin
exceeded
recommended
threshold
20
μg/kg,
particularly
starter
feeds
(S1,
S3,
S7)
finisher
S4).
Statistical
analyses
that
dominant
factors
influencing
quality.
Moisture
contributed
fungal
growth
subsequent
with
a
positive
correlation
(r
=
0.92)
negative
−
0.68).
Higher
may
reduce
concentration
increase
risk
contamination.
indicates
contamination
significantly
affect
across
plants.
Broilers
exposed
high
experienced
reduced
rates,
immunosuppression,
increased
mortality.
Layers
showed
decreased
egg
production
quality
prolonged
exposure.
recommendations
include
improved
control,
regular
testing,
use
detoxifying
agents
mitigate
ensuring
consumer
safety.
Journal of Biomolecular Structure and Dynamics,
Год журнала:
2024,
Номер
unknown, С. 1 - 19
Опубликована: Фев. 6, 2024
Streptomyces
spp.
are
considered
excellent
reservoirs
of
natural
bioactive
compounds.
The
study
evaluated
the
potential
secondary
metabolites
from
sp.
strain
130
through
PKS-I
and
NRPS
gene-clusters
screening.
GC-MS
analysis
was
done
for
metabolic
profiling
compounds
in
next
set
experiments.
Identified
antifungal
underwent
ADMET
analyses
to
screen
their
toxicity.
All
compounds'
molecular
docking
with
structural
gene
products
aflatoxin
biosynthetic
pathway
Aspergillus
flavus.
MD
simulations
were
utilized
evaluate
stability
protein-ligand
complexes
under
physiological
conditions.
Based
on
in-silico
studies,
compound
2,4-di-tert
butyl-phenol
(DTBP)
selected
in-vitro
studies
against
Simultaneously,
extracted
two
different
solvents
(ethyl-acetate
methanol)
used
similar
assays.
MIC
value
DTBP
found
be
314
µg/mL,
whereas
ethyl-acetate
extract
methanol-extract,
it
250
350
respectively.
A
mycelium
growth
assay
analyze
effect
compounds/extracts
formation
In
agar
diffusion
assay,
zone
inhibitions
DTBP,
extract,
methanol
observed
diameters
11.3,
13.3,
7.6
mm,
curve
treated
samples
have
delayed
fungi,
which
signified
that
a
fungistatic
nature.
Spot
has
determined
fungal
sensitivity
sub-minimum
inhibitory
concentration
study's
results
suggested
can
exploited
antifungal-drug
development.
Phytochemical Analysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 11, 2024
Abstract
Introduction
Aflatoxins,
potent
carcinogens
produced
by
Aspergillus
species,
present
significant
health
risks
and
commonly
contaminate
herbal
products
such
as
Chrysanthemum
morifolium
.
Detecting
these
toxins
in
C.
proves
challenging
due
to
the
complex
nature
of
matrix
fluctuating
levels
found
different
samples.
Objectives
This
study
aimed
develop
optimize
a
novel
method
for
detection
aflatoxins
using
dispersive
liquid–liquid
microextraction
combined
with
high‐performance
liquid
chromatography‐fluorescence
based
on
quality
design
principles.
Methodology
The
involved
determining
critical
attributes
parameters
through
Plackett–Burman
design,
followed
optimization
Box–Behnken
design.
Monte
Carlo
simulation
was
employed
establish
space,
which
experimentally
verified.
Method
validation
performed
confirm
accuracy,
precision,
stability.
Results
developed
exhibited
excellent
linearity
(
R
2
>
0.9991)
B
1
,
G
across
range
concentrations,
recovery
rates
between
85.52%
102.01%.
validated
effectively
quantified
under
storage
conditions,
highlighting
impact
temperature
time
aflatoxin
production.
Conclusion
successfully
established
reliable
effective
importance
strict
conditions
reduce
contamination.
Using
framework,
demonstrated
robustness
high
analytical
performance,
making
it
suitable
routine
control
products.
Scientific Papers Journal VETERINARY SERIES,
Год журнала:
2024,
Номер
67(1), С. 67 - 75
Опубликована: Ноя. 13, 2024
Milk
and
dairy
products
are
essential
nutritious
foods
for
all
age
groups,
especially
infants
children.
Their
consumption
can
be
dangerous
due
to
a
harmful
substance
called
aflatoxin
M1
(AFM1),
the
that
comes
from
conversion
of
B1
present
in
animal
feed.
Due
ingesting
feed
contaminated
with
B1,
cattle
secrete
into
their
milk.
Therefore,
such
as
milk,
cheese,
yogurts
have
potential
this
toxic
substance.
Although
its
toxicity
is
lower
than
it
relatively
stable
during
storage,
pasteurization,
processing.
Aflatoxins
part
most
important
group
mycotoxins,
mycotoxins
being
compounds
produced
mainly
by
fungi
genera
Aspergillus,
Fusarium,
Penicillium
which
contaminate
many
types
food
through
stability
chain
reach
consumer.
Nowadays,
contamination
significant.
The
objective
paper
provide
an
overview
importance
mycotoxin
M1,
occurrence,
factors
influence
transfer
rates,
method
determining
effects
resulting
mycotoxin.
milk
poses
major
risk
mankind,
these
regularly
consumed
daily
diet.
