Uludağ Arıcılık Dergisi,
Год журнала:
2024,
Номер
24(2), С. 417 - 441
Опубликована: Ноя. 6, 2024
Propolis,
a
natural
resinous
substance
produced
by
bees,
has
long
been
known
for
its
potential
health
benefits.
This
study
aims
to
present
comprehensive
bibliometric
investigation,
exploring
the
dynamicity,
spatiotemporal
trends,
and
emerging
patterns
in
scholarly
discourse
surrounding
propolis
research.
The
tailed
PRISMA
guidelines
used
MeSH
databases
Scopus
retrieve
relevant
bibliographic
data
spanning
75
years.
R-based
Bibliometrix
VOSviewer
applications
were
employed
analysis.
A
noticeable
increase
production
was
observed
last
two
decades.
Active
participation
research
identified
from
Brazil,
China,
Türkiye.
multidimensional
nature
of
evident
through
diversity
topics
covered
highly
impactful
intellectual
maps
information
sources.
Thematic
evolution
highlighted
dynamic
research,
with
areas
investigation
an
enhanced
understanding
therapeutic
applications.
Five
prominent
themes
emerged:
"propolis,"
"oxidative
stress,"
"honey,"
"beeswax,"
"allergic
contact
dermatitis."
Additionally,
included
chronic
kidney
disease,
COVID-19,
metabolomics.
Mapping
international
cooperation
co-citation
authors
demonstrated
multiple
activities.
findings
this
hold
implications
researchers,
healthcare
professionals,
policymakers,
providing
insights
into
current
landscape
Green Energy and Resources,
Год журнала:
2024,
Номер
2(2), С. 100073 - 100073
Опубликована: Апрель 15, 2024
This
research
presents
a
facile
and
inexpensive
method
for
synthesizing
ZnO
nanoparticles
using
Nauclea
latifolia
fruit
extract
as
bioreductant
stabilizer.
The
prepared
particles
were
characterized
some
analytical
techniques,
including
X-ray
diffraction
(XRD)
crystallinity
phase
identification,
scanning
electron
microscopy
(SEM)
to
study
surface
morphology,
Fourier
transform
infrared
(FTIR)
spectroscopy
functional
groups
analysis,
transmission
(TEM)
grain
size
UV-Vis
optical
properties,
Brunauer-Emmett-Teller
(BET)
area
analysis.
XRD
analysis
revealed
hexagonal
wurtzite
structure
with
an
average
crystallite
of
14.40
nm.
FTIR
showed
absorption
peaks
at
3659,
1341,
460
cm-1,
corresponding
hydroxyl,
carboxylic,
Zn
–
O,
respectively.
SEM
image
agglomerated
morphology
flower-like
shape.
TEM
estimated
the
particle
range
be
12.54
-
17.35
broad
peak
373
BET
277.420
m2/g
specific
area.
A
batch
adsorption
experiment
conducted
on
performance
methyl
green
(MG)
removal
from
aqueous
solution
highest
efficiency
99.96%
60
min
agitation
time
pH
7,
0.05
g
NPs,
confirming
particles.
results
modelling
that
data
best
fit
Freundlich
isotherm
general-order
kinetic
models.
Thermodynamic
investigation
confirmed
process
spontaneous,
feasible,
endothermic,
physical.
Finally,
simplicity
synthesis
evaluation
indicate
efficient
cost-effective
adsorbent
MG
recovery
has
been
successfully
prepared.
Archiv der Pharmazie,
Год журнала:
2024,
Номер
357(7)
Опубликована: Март 19, 2024
Fraxetin
is
a
bioactive
molecule
present
in
various
natural
plants,
especially
Cortex
Fraxini.
Evidenced
outcomes
phytochemical
and
biological
analyses
for
this
agent
are
now
available
the
literature,
but
an
insightful
review
yet
unknown.
The
goal
of
current
research
to
offer
panoramic
illustration
observation,
biosynthesis,
synthesis,
pharmacology,
pharmacokinetics
fraxetin.
Esculetin
ferulic
acid
acted
as
precursors
enzymatic
biosynthetic
route,
whereas
fraxetin
could
be
easily
synthesized
from
simple
phenols.
A
great
deal
interest
was
obtained
using
pharmacological
targets.
Herein,
its
value
included
anticancer,
antioxidative,
anti-inflammatory,
antidiabetic,
antiobesity,
antimicrobial
activities,
well
protection
liver,
neurons,
heart,
bone,
lung,
kidney,
others.
Anticancer
activity
may
involve
inhibition
proliferation,
invasion,
migration,
together
with
apoptotic
induction.
Health
benefits
were
deduced
ability
suppress
cytokines
protect
immune
syndrome.
Various
signaling
pathways,
such
Janus
kinase
2
(JAK2)/signal
transducer
activator
transcription
3
(STAT3),
phosphoinositide
(PI3K)/protein
B
(Akt),
nuclear
factor
kappa
(NF-κB)/NLRP3,
Akt/AMPK,
have
been
proposed
vitro
vivo
mechanisms
action.
highly
distributed
rat
plasma
several
organs.
However,
more
pharmacokinetic
studies
improve
bioavailability
needed
since
solubility
water
still
limited.
Food Science & Nutrition,
Год журнала:
2023,
Номер
12(3), С. 1928 - 1939
Опубликована: Дек. 7, 2023
Abstract
This
study
presents
the
first
findings
regarding
extraction,
isolation,
enzyme
inhibition,
and
antioxidant
activity.
The
oral
mucosal
wound‐healing
process
was
investigated
using
propolis
water
extract
(PWE)
incubation
with
gingival
fibroblast
cells
concluded
that
effective
on
pattern
compared
to
untreated
controls.
Additionally,
phenolic
compounds
(fraxetin,
apigenin,
galangin,
pinobanksin,
chrysin,
etc.)
were
isolated
from
propolis,
their
chemical
structures
elucidated
comprehensive
spectroscopic
methods.
anti‐Alzheimer
potential
activities
of
PWE
some
screened
revealing
inhibitory
effects
acetylcholinesterase
(AChE)
IC
50
values
ranging
0.45
±
0.01
1.15
0.03
mM,
as
well
remarkable
free‐radical
scavenging
metal
reduction
capacities.
results
suggest
these
can
be
used
therapeutic
agents
due
properties
AChE.
It
also
for
purposes
since
its
effect
is
promising.
Food Science & Nutrition,
Год журнала:
2024,
Номер
12(4), С. 2724 - 2735
Опубликована: Янв. 11, 2024
Abstract
Ethanol
has
been
widely
used
for
the
extraction
of
propolis.
Due
to
its
certain
disadvantages,
there
an
ongoing
search
find
alternative
non‐ethanolic
solvents.
This
study
aimed
compare
phenolics,
antioxidant,
and
antibacterial
activity
propolis
extracts
prepared
with
70%
ethanol
(EWE),
propylene
glycol
(PGE),
L‐arginine
solution
(BE).
All
were
subjected
in
vitro
simulated
digestion
procedure,
phenolic
profile
non‐digested
digested
samples
was
determined
by
using
LC–MS/MS.
Additionally,
change
total
(TPC),
flavonoid
content
(TFC),
antioxidant
capacities
at
each
phase.
TPC
TFC
had
similar
values,
although
BE
showed
higher
capacity
(
p
<
.05).
The
amount
reached
or
transformed
intestinal
stage
PG
compared
EWE.
also
provided
highest
assay
samples.
most
common
phenolics
pinocembrin,
pinobanskin,
galangin,
CAPE
extracts.
However,
their
concentration
drastically
reduced
digestion,
recovery
(R%)
ranged
from
0%
9.38%
initial
detected
Chrysin
bioaccessible
all
Among
acids,
R%
trans‐cinnamic
acid
(22.14%)
BE.
inhibitory
against
Escherichia
coli
Staphylococcus
aureus.
suggests
that
could
be
as
solvent
extraction.
Molecules,
Год журнала:
2025,
Номер
30(1), С. 189 - 189
Опубликована: Янв. 6, 2025
Propolis
is
a
valuable
natural
resource
for
extracting
various
beneficial
compounds.
This
study
explores
sustainable
extraction
approach
Brazilian
green
propolis.
First,
supercritical
fluid
(SFE)
process
parameters
were
optimized
(co-solvent:
21.11%
v/v
CPME,
and
temperature:
60
°C)
to
maximize
yield,
total
phenolic
content
(TPC),
antioxidant
capacity,
LOX
(lipoxygenase)
inhibitory
activity.
GC–MS
analysis
identified
40
metabolites
in
SFE
extracts,
including
fatty
acids,
terpenoids,
phenolics,
sterols.
After
selecting
the
optimum
parameters,
sequential
high-pressure
(HPE)
was
developed,
comprising
SFE,
pressurized
liquid
(PLE)
with
EtOH/H2O,
subcritical
water
(SWE).
compared
similar
using
low-pressure
extractions
(LPE)
Soxhlet
extractor.
The
HPE
achieved
significantly
higher
overall
yield
(80.86%)
than
LPE
(71.43%).
showed
selectivity,
resulting
lower
carbohydrate
non-polar
fraction,
PLE
extracted
nearly
twice
protein
amount
of
LPE–2.
Despite
extracts
exhibited
better
acetylcholinesterase
(AChE),
butyrylcholinesterase
(BChE),
inhibition,
demonstrating
that
neuroprotective
anti-inflammatory
activity
may
be
associated
symbiosis
set
Finally,
comprehensive
greenness
assessment
revealed
proved
more
aligned
chemistry
principles
method.
Plants,
Год журнала:
2025,
Номер
14(7), С. 1071 - 1071
Опубликована: Апрель 1, 2025
This
study
aimed
to
compare
the
efficiency
of
different
green
extraction
methods
for
obtaining
bioactive
compounds
from
roots
Rheum
cordatum
Losinsk
and
evaluate
their
antioxidant
antimicrobial
properties.
The
presence
some
important
phytochemicals
in
extracts
obtained
using
ultrasound-assisted
(UAE),
subcritical
ethanol
(Sbc-EtOH),
supercritical
CO2
(ScCO2)
was
determined
by
LC-MS/MS,
properties
were
examined
against
Staphylococcus
aureus,
Enterococcus
faecalis,
Pseudomonas
aeruginosa,
Escherichia
coli.
goal
determine
optimal
conditions
that
maximize
yield
while
preserving
biological
Different
pressures
(100
bar
400
bar)
tested
UAE
extraction,
solvents
times
Sbc-EtOH
ScCO2
extraction.
Most
53
phenolic
have
been
extracted
method,
either
exclusively
or
highest
amounts.
It
has
observed
more
higher
amounts
at
lower
pressure.
activity
exhibited
extracts.
Additionally,
ScCO2-100
extract
100
showed
strong
activity,
with
a
minimum
inhibitory
concentration
(MIC)
ranging
31.25
250
μg/mL.
Gallic
acid,
epicatechin
gallate,
epigallocatechin
catechin
found
molecular
docking
studies
1QWZ,
2ANQ,
3H77,
6QXS
proteins
revealed
scores
-6.127,
-9.479,
-5.836,
-7.067
kcal/mol,
respectively.
