Inflammatory parameters mediates the relationship between dietary index for gut microbiota and frailty in middle-aged and older adults in the United States: findings from a large-scale population-based study DOI Creative Commons
Qingxia Yang,

Xiaoyun Wu,

Jianguo Duan

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 16, 2025

Frailty is a prevalent geriatric syndrome marked by diminished physiological reserves and heightened vulnerability to stressors, leading adverse health outcomes imposing significant economic burdens on healthcare systems. This study investigates the relationship between Dietary Index for Gut Microbiota (DI-GM) risk of frailty in middle-aged older adults, using data from National Health Nutrition Examination Survey (NHANES) collected 2007 2018. Weighted logistic regression, subgroup analysis, restricted cubic splines (RCS) were performed evaluate DI-GM risk. Additionally, mediation analysis was conducted investigate influence relevant inflammatory parameters complete blood count, including leukocyte neutrophil lymphocyte ratio (NLR), systemic response index (SIRI), elucidate how may onset progression frailty. In this cross-sectional 8,695 participants with mean age 65.56 years, 3,173 individuals classified as frail. After adjusting all covariates, inverse observed Quartile revealed that highest quartile had significantly lower odds compared those lowest (OR: 0.80, 95% CI: 0.65-0.99, p = 0.04). Trend analyses across models demonstrated consistent higher quartiles (p < 0.0001 crude model; 0.001 Model 1; 0.04 2). Subgroup confirmed stability impact various subgroups. RCS showed decreased linearly increasing levels. Mediation indicated effects NLR, SIRI, proportions 5.7, 7.9, 4.4, 5.5%, respectively (all 0.001). The levels are inversely associated frailty, part association mediated parameters.

Язык: Английский

Inflammatory parameters mediates the relationship between dietary index for gut microbiota and frailty in middle-aged and older adults in the United States: findings from a large-scale population-based study DOI Creative Commons
Qingxia Yang,

Xiaoyun Wu,

Jianguo Duan

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 16, 2025

Frailty is a prevalent geriatric syndrome marked by diminished physiological reserves and heightened vulnerability to stressors, leading adverse health outcomes imposing significant economic burdens on healthcare systems. This study investigates the relationship between Dietary Index for Gut Microbiota (DI-GM) risk of frailty in middle-aged older adults, using data from National Health Nutrition Examination Survey (NHANES) collected 2007 2018. Weighted logistic regression, subgroup analysis, restricted cubic splines (RCS) were performed evaluate DI-GM risk. Additionally, mediation analysis was conducted investigate influence relevant inflammatory parameters complete blood count, including leukocyte neutrophil lymphocyte ratio (NLR), systemic response index (SIRI), elucidate how may onset progression frailty. In this cross-sectional 8,695 participants with mean age 65.56 years, 3,173 individuals classified as frail. After adjusting all covariates, inverse observed Quartile revealed that highest quartile had significantly lower odds compared those lowest (OR: 0.80, 95% CI: 0.65-0.99, p = 0.04). Trend analyses across models demonstrated consistent higher quartiles (p < 0.0001 crude model; 0.001 Model 1; 0.04 2). Subgroup confirmed stability impact various subgroups. RCS showed decreased linearly increasing levels. Mediation indicated effects NLR, SIRI, proportions 5.7, 7.9, 4.4, 5.5%, respectively (all 0.001). The levels are inversely associated frailty, part association mediated parameters.

Язык: Английский

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