Exploring the Utility of Prunus mahaleb Extracts as a Source of Natural Bioactive Compounds for Functional Applications
Food Science & Nutrition,
Год журнала:
2025,
Номер
13(4)
Опубликована: Март 28, 2025
ABSTRACT
Prunus
mahaleb
has
garnered
attention
as
a
potent
medicinal
agent
and
functional
component.
We
aimed
to
detect
the
chemical
composition
biological
activities
of
several
parts
(fruit,
leaves,
twigs)
P.
.
Biological
were
assessed
for
antioxidant
properties,
enzyme
inhibition,
mutagenic/antimutagenic
effects,
antibacterial
efficacy.
Antioxidant
capabilities
evaluated
using
various
assays,
including
DPPH,
ABTS,
CUPRAC,
FRAP,
phosphomolybdenum,
metal
chelating.
The
constituents
extracts
identified
quantified
HPLC‐ESI‐MS/MS
method.
effects
inhibition
examined
on
some
enzymes,
AChE,
BChE,
tyrosinase,
amylase,
glucosidase.
Ames
test
was
used
evaluate
mutagenic
antimutagenic
properties
plant
extracts.
Furthermore,
broth
microdilution
assay
employed
possible
against
microorganisms.
methanol
extract
twigs
showed
superior
(DPPH:
388.39
mg
TE/g;
ABTS:
701.50
CUPRAC:
459.05
FRAP:
264.99
TE/g).
demonstrated
highest
tyrosinase
inhibitory
activity
(61.91
KAE/g).
A
total
40
metabolites,
mainly
flavonoids,
detected
through
analysis,
revealing
that
ferulic
acid,
naringenin,
herniarin
predominant
compounds.
In
test,
tested
exhibited
no
potential.
antimutagenicity
ethyl
acetate
from
leaves
particularly
efficient
frameshift
base
pair
substitution
mutations
induced
by
recognized
mutagens.
metabolic
activation
system
amplified
these
strong
rates
ranging
85%
98%.
results
indicated
effectiveness
at
dosages
between
6.25
0.195
mg/mL,
effective
Sarcina
lutea,
Bacillus
cereus
,
Candida
albicans
Staphylococcus
aureus
Our
findings
indicate
can
serve
versatile
raw
material
development
health‐promoting
applications,
medicines,
cosmeceuticals,
nutraceuticals.
Язык: Английский
The Biopotential of Bellardia trixago in Replacing Synthetic Compounds for Health‐Promoting Applications: Is It a Promising Candidate?
Food Science & Nutrition,
Год журнала:
2025,
Номер
13(4)
Опубликована: Апрель 1, 2025
ABSTRACT
Bellardia
trixago
(L.)
All.
(family
Orobanchaceae)
is
a
facultative
hemiparasitic
plant
used
traditionally
to
cure
many
diseases.
The
present
study
was
designed
evaluate
the
phenolic
constituents,
antioxidant,
enzyme
inhibitory,
and
cytotoxic
properties
of
aerial
parts
B.
.
Ethyl
acetate
(EtOAc),
ethanol
(EtOH),
70%
EtOH
extracts
were
prepared
by
maceration,
while
aqueous
extract
infusion.
Rutin,
4‐hydroxy
benzoic
acid,
ferulic
p
‐coumaric
hyperoside,
delphinidin
3,5
diglucoside,
kaempferol,
isoquercitrin
identified
in
most
with
variable
concentrations,
but
generally,
or
accumulated
highest
contents.
displayed
best
antiradical
(DPPH
=
13.55
mg
TE/g;
ATBS
53.78
TE/g)
ion‐reducing
(CUPRAC
50.09
FRAP
24.73
properties.
recorded
chelating
iron
power
(12.91
EDTAE/g)
EtOAc
exerted
total
antioxidant
activity
(2.29
2.49
mmol
TE/g,
>
0.05).
cholinesterase
(anti‐AChE
2.91
GALAE/g;
anti‐BchE
2.62
GALAE/g)
α‐glucosidase
(1.19
ACAE/g)
inhibition
from
extract,
that
against
α‐amylase
obtained
(0.69
ACAE/g).
toward
HT‐29
cell
line,
where
effect
(IC
50
38.42
μg/mL)
extract.
Furthermore,
network
pharmacology
analysis
revealed
critical
gene
targets
pathways
associated
bioactive
compounds.
Molecular
docking
studies
favorable
binding
modes
interaction
patterns
major
compounds
key
colon
cancer‐related
proteins,
which
further
supported
molecular
dynamics
simulations.
As
first
investigation
into
composition
pharmacological
effects
,
this
highlights
its
potential
as
promising
source
therapeutic
relevance
for
oxidative
stress‐related
conditions.
Язык: Английский