Anchusa officinalis accelerates wound healing via the improvement of transforming growth factor beta 1 expressions, antioxidant levels, and inhibition of TNF-α, IL-6 DOI

Safwan Aladwan,

Talal Salem Al‐Qaisi, Ahmed Aj. Jabbar

и другие.

Cutaneous and Ocular Toxicology, Год журнала: 2025, Номер unknown, С. 1 - 14

Опубликована: Март 26, 2025

Wound healing is an intricate, complicated process that needs special attention because of its related complications may occur if not treated properly or therapeutic insufficiency. Common bugloss (Anchusa officinalis L.) a deep-rooted, hairy perennial herb used in folk medicine for numerous human issues, including wound recovery. To delineate safety and potentials, we investigated the acute toxicity wound-healing effects Anchusa L. (APEAO) aerial part extracts on excisional neck injury rats. A uniform dorsal cut was formed twenty-four albino rats, which were arbitrarily divided into 4 groups daily with topical 0.2 ml dose following: group A, rats received 10% tween 20; B, intrasite gel; C D, had 250 500 mg/kg APEAO, respectively. The APEAO treatment did cause toxic damage administered up to 5 g/kg APEAO. In experiment, APEAO-treated skin exhibited significantly higher deposition tissue collagen fibroblast cells. contrast, inflammatory cells lower recovered tissues than positve control Topical application caused positive modulation Transforming Growth Factor Beta 1 (angiogenesis) skin, indicating elevated growth faster action. Moreover, significant elevation antioxidants (Superoxide dismutase, glutathione peroxidase, catalyze) hydroxyproline (collagen) content, lowering Malondialdehyde levels compared vehicle Serum chemicals (Transforming factor α, Interlukin-6, Interlukin-10) modulated following application. outcomes revealed regeneration potentials by modulatory actions several cellular processes, could serve as scientific evidence future investigation regarding production potent pharmaceuticals contraction.

Язык: Английский

Anchusa officinalis accelerates wound healing via the improvement of transforming growth factor beta 1 expressions, antioxidant levels, and inhibition of TNF-α, IL-6 DOI

Safwan Aladwan,

Talal Salem Al‐Qaisi, Ahmed Aj. Jabbar

и другие.

Cutaneous and Ocular Toxicology, Год журнала: 2025, Номер unknown, С. 1 - 14

Опубликована: Март 26, 2025

Wound healing is an intricate, complicated process that needs special attention because of its related complications may occur if not treated properly or therapeutic insufficiency. Common bugloss (Anchusa officinalis L.) a deep-rooted, hairy perennial herb used in folk medicine for numerous human issues, including wound recovery. To delineate safety and potentials, we investigated the acute toxicity wound-healing effects Anchusa L. (APEAO) aerial part extracts on excisional neck injury rats. A uniform dorsal cut was formed twenty-four albino rats, which were arbitrarily divided into 4 groups daily with topical 0.2 ml dose following: group A, rats received 10% tween 20; B, intrasite gel; C D, had 250 500 mg/kg APEAO, respectively. The APEAO treatment did cause toxic damage administered up to 5 g/kg APEAO. In experiment, APEAO-treated skin exhibited significantly higher deposition tissue collagen fibroblast cells. contrast, inflammatory cells lower recovered tissues than positve control Topical application caused positive modulation Transforming Growth Factor Beta 1 (angiogenesis) skin, indicating elevated growth faster action. Moreover, significant elevation antioxidants (Superoxide dismutase, glutathione peroxidase, catalyze) hydroxyproline (collagen) content, lowering Malondialdehyde levels compared vehicle Serum chemicals (Transforming factor α, Interlukin-6, Interlukin-10) modulated following application. outcomes revealed regeneration potentials by modulatory actions several cellular processes, could serve as scientific evidence future investigation regarding production potent pharmaceuticals contraction.

Язык: Английский

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