ACS Omega,
Год журнала:
2024,
Номер
9(43), С. 43817 - 43825
Опубликована: Окт. 21, 2024
Bulking
agents
have
gained
attention
as
new,
minimally
invasive
treatments
for
fecal
incontinence.
Various
materials
and
surface
treatment
techniques
been
extensively
studied
to
ensure
good
biocompatibility
long-term
stability.
Despite
significant
improvements
in
biocompatibility,
the
nonuniform
particle
size
of
existing
has
led
other
challenges,
such
induction
phagocytosis
or
reduction
injectability
during
vivo
tests.
This
study
aimed
conduct
a
preclinical
test
midterm
stability
bulking
with
newly
formulated
particles
uniform
size.
To
this
end,
were
fabricated
using
microfluidics,
resulting
narrow
dispersity
less
than
5%
coefficient
variation,
which
is
essentially
distinct
from
conventional
agents.
The
microfluidic
fabrication
resulted
uniformly
sized
larger
migratory
limit
80
μm
maximum
injection
pressure.
Histological
staining
microscopic
observations
confirmed
proper
positioning
filler
negligible
immune
response
up
6
months,
indicating
successful
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Engineered
living
systems
(ELSs)
represent
purpose-driven
assemblies
of
components,
encompassing
cells,
biomaterials,
and
active
agents,
intricately
designed
to
fulfill
diverse
biomedical
applications.
Gelatin
its
derivatives
have
been
used
extensively
in
ELSs
owing
their
mature
translational
pathways,
favorable
biological
properties,
adjustable
physicochemical
characteristics.
This
review
explores
the
intersection
gelatin
with
fabrication
techniques,
offering
a
comprehensive
examination
synergistic
potential
creating
for
various
applications
biomedicine.
It
offers
deep
dive
into
gelatin,
including
structures
production,
sources,
processing,
properties.
Additionally,
techniques
employing
derivatives,
generic
microfluidics,
3D
printing
methods.
Furthermore,
it
discusses
based
on
regenerative
engineering
as
well
cell
therapies,
bioadhesives,
biorobots,
biosensors.
Future
directions
challenges
are
also
examined,
highlighting
emerging
trends
areas
improvements
innovations.
In
summary,
this
underscores
significance
gelatin-based
advancing
lays
groundwork
guiding
future
research
developments
within
field.
Abstract
The
remarkable
control
function
over
the
functional
material
formation
process
enabled
by
droplet
microfluidic
emulsification
approaches
can
lead
to
efficient
and
one‐step
encapsulation
of
active
substances
in
microparticles,
with
microparticle
characteristics
well
regulated.
In
comparison
conventional
fabrication
methods,
technology
not
only
construct
microparticles
various
shapes,
but
also
provide
excellent
templates,
which
enrich
expand
application
fields
microparticles.
For
instance,
intersection
disciplines
pharmacy,
life
sciences,
others,
modifying
structure
microspheres
appending
materials
be
completed
preparation
as‐prepared
polymer
particles
have
great
potential
a
wide
range
applications
for
chemical
analysis,
heavy
metal
adsorption,
detection.
This
review
systematically
introduces
devices
basic
principles
particle
using
discusses
research
high
monodispersity,
involving
plethora
types
including
spherical,
nonspherical,
Janus
type,
as
core–shell,
hole–shell,
controllable
multicompartment
particles.
Moreover,
this
paper
exhibits
critical
analysis
current
status
existing
challenges,
outlook
future
development
emerging
has
been
discussed.
Molecules,
Год журнала:
2024,
Номер
29(2), С. 398 - 398
Опубликована: Янв. 13, 2024
This
review
presents
a
comprehensive
evaluation
for
the
manufacture
of
organic
molecules
via
efficient
microfluidic
synthesis.
Microfluidic
systems
provide
considerably
higher
control
over
growth,
nucleation,
and
reaction
conditions
compared
with
traditional
large-scale
synthetic
methods.
synthesis
has
become
crucial
technique
quick,
affordable,
organometallic
compounds
complicated
characteristics
functions.
Therefore,
unique,
straightforward
flow
methodology
can
be
developed
to
conduct
syntheses
improve
their
efficiency.
Chemical Communications,
Год журнала:
2024,
Номер
60(65), С. 8497 - 8515
Опубликована: Янв. 1, 2024
Continuous
flow
synthesis
offers
a
powerful
approach
for
MOF
&
composite
creation.
This
review
explores
its
recent
advancements,
advantages
over
batch
methods,
impact
on
properties.
Expert Opinion on Drug Delivery,
Год журнала:
2025,
Номер
unknown, С. 1 - 20
Опубликована: Янв. 7, 2025
Introduction
The
pursuit
of
linear
dosage
in
pharmacy
is
essential
for
achieving
consistent
therapeutic
release
and
enhancing
patient
compliance.
This
review
provides
a
comprehensive
summary
zero-order
drug
delivery
systems,
with
particular
focus
on
reservoir-based
systems
emanated
from
different
microfabrication
technologies.
Micromachines,
Год журнала:
2025,
Номер
16(2), С. 132 - 132
Опубликована: Янв. 24, 2025
Step
emulsification
(SE)
is
renowned
for
its
robustness
in
generating
monodisperse
emulsion
droplets
at
arrayed
nozzles.
However,
few
studies
have
explored
poly(dimethylsiloxane)
(PDMS)-based
SE
devices
producing
oil-in-water
(O/W)
and
polymeric
microspheres
with
diameters
below
20
µm-materials
broad
applicability.
In
this
study,
we
present
a
PDMS-based
microfluidic
device
designed
to
achieve
goal.
Two
264
nozzles
each
were
fabricated,
featuring
straight
triangular
nozzle
configurations,
both
height
of
4
µm
minimum
width
10
µm.
The
rendered
hydrophilic
via
oxygen
plasma
treatment.
A
photocurable
acrylate
monomer
served
as
the
dispersed
phase,
while
an
aqueous
polyvinyl
alcohol
solution
acted
continuous
phase.
produced
polydisperse
exceeding
30
coefficient-of-variation
(CV)
values
above
10%.
contrast,
nozzles,
opening
38
µm,
consistently
generated
CVs
4%,
maximum
throughput
0.5
mL
h-1.
Off-chip
photopolymerization
these
yielded
acrylic
microspheres.
low-cost,
disposable,
scalable
offers
significant
potential
applications
spanning
from
laboratory-scale
research
industrial-scale
particle
manufacturing.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(36)
Опубликована: Апрель 16, 2024
Abstract
Targeted
drug
delivery
system
(DDS)
holds
exciting
prospects
in
biomedical
clinical
research
and
development.
However,
it
faces
a
significant
challenge
achieving
stable
safe
targeted
transportation
without
leakage
while
obtaining
precise
controllable
dosing
with
high
utilization
rate
low
side
effects.
Herein,
an
optical
tweezers‐based
light‐driven
technique
is
proposed
to
transport
construct
multi‐core/shell
microdroplets
enveloping
carriers
target
cells
as
novel,
safe,
efficient
DDS.
Drug‐loaded
core/shell
structures
are
first
fabricated
by
new
simple
injection
extrusion
method
then
transported
cell
dynamic
trap
power,
which
ensures
no
leakage,
exogenous
materials,
biothermal
damage
introduced
during
the
process.
Next,
realized
pushing
into
drug‐loaded
microdroplet
under
actions
of
forces,
constructs
structure
pure
environment
improve
action
efficiency.
Moreover,
quantitative
can
also
achieved
controlling
sizes/number
droplets
inside
microdroplets.
This
DDS
great
interest
frontier
medical
disease
treatment
fields.
Lab on a Chip,
Год журнала:
2024,
Номер
24(19), С. 4623 - 4631
Опубликована: Янв. 1, 2024
Monodisperse
biodegradable
polymer
microspheres
show
broad
applications
in
drug
delivery
and
other
fields.
In
this
study,
we
developed
an
effective
method
that
combines
microfluidics
with
interfacial
instability
to
prepare
monodispersed
poly(lactic-
