Neurological sequel of chronic kidney disease: From diminished Acetylcholinesterase activity to mitochondrial dysfunctions, oxidative stress and inflammation in mice brain

Scientific Reports, Год журнала: 2019, Номер 9(1)

Опубликована: Фев. 28, 2019

Abstract With increasing prevalence, chronic kidney disease (CKD) has become a global health problem. Due to the retention of uremic toxins, electrolytes and water, resultant metabolic disturbances, CKD affects several organs, including nervous system. Thus, patients suffer from neurological complications, dementia, cognitive impairment, motor abnormalities, depression, mood sleep disturbances. However, mechanisms underlying complications are least elucidated. We have recently reported highly reproducible mice model induced by high adenine diet, which exhibited psychomotor behavioral abnormalities blood-brain barrier disruption. In present study, using model, we investigated psycho-motor behaviour, neurochemical histopathological alterations in brain relevant observed behavioural abnormalities. The results demonstrate loss Acetylcholinesterase activity, decrease neuronal arborisation dendritic spine density discrete regions, mice. Oxidative stress, inflammation, mitochondrial dysfunctions were found specific regions mice, been regarded as causes alterations. study is immense importance, therapeutic implications management CKD-associated complications.

Язык: Английский

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Molecular and functional properties of cortical astrocytes during peripherally induced neuroinflammation

Cell Reports, Год журнала: 2021, Номер 36(6), С. 109508 - 109508

Опубликована: Авг. 1, 2021

Astrocytic contributions to neuroinflammation are widely implicated in disease, but they remain incompletely explored. We assess medial prefrontal cortex (PFC) and visual (VCX) astrocyte whole-tissue gene expression changes mice following peripherally induced triggered by a systemic bacterial endotoxin, lipopolysaccharide, which produces sickness-related behaviors, including anhedonia. Neuroinflammation-mediated behavioral astrocyte-specific alterations peak when anhedonia is greatest then reverse normal. Notably, region-specific molecular identities of PFC VCX astrocytes largely maintained during reactivity changes. Gene pathway analyses reveal diverse cell signaling pathways, cell-cell interactions multiple types that may underlie the central effects neuroinflammation. Certain signatures accompanying shared with reported Alzheimer's disease mouse models. However, we find no evidence altered neuronal survival or function even neuroinflammation-induced significant.

Язык: Английский

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Astrocyte regulation of synaptic signaling in psychiatric disorders

Neuropsychopharmacology, Год журнала: 2022, Номер 48(1), С. 21 - 36

Опубликована: Май 16, 2022

Язык: Английский

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Beyond the neuron: Role of non-neuronal cells in stress disorders

Neuron, Год журнала: 2022, Номер 110(7), С. 1116 - 1138

Опубликована: Фев. 18, 2022

Язык: Английский

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Astrocytes and major depression: The purinergic avenue

Neuropharmacology, Год журнала: 2022, Номер 220, С. 109252 - 109252

Опубликована: Сен. 16, 2022

Язык: Английский

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