CD2AP at the junction of nephropathy and Alzheimer’s disease DOI Creative Commons

Milène Vandal,

Mohsen Janmaleki,

Isabel M. Rea

и другие.

Molecular Neurodegeneration, Год журнала: 2025, Номер 20(1)

Опубликована: Июнь 3, 2025

Polymorphisms in the gene encoding CD2-associated protein (CD2AP) are associated with an increased risk for developing Alzheimer's disease (AD). Intriguingly, variants also cause a pattern of kidney injury termed focal segmental glomerulosclerosis. Recent studies have investigated cell types and mechanisms by which CD2AP dosage contributes to key pathological features AD. This review summarizes fundamental roles mammalian cells systems, discusses novel pathogenic focused on AD highlights necessity incorporating biological sex research. Finally, article draws important parallels between brain physiology based vascular molecular organization, links AD, suggests existence kidney-brain axis centered CD2AP.

Язык: Английский

CD2AP at the junction of nephropathy and Alzheimer’s disease DOI Creative Commons

Milène Vandal,

Mohsen Janmaleki,

Isabel M. Rea

и другие.

Molecular Neurodegeneration, Год журнала: 2025, Номер 20(1)

Опубликована: Июнь 3, 2025

Polymorphisms in the gene encoding CD2-associated protein (CD2AP) are associated with an increased risk for developing Alzheimer's disease (AD). Intriguingly, variants also cause a pattern of kidney injury termed focal segmental glomerulosclerosis. Recent studies have investigated cell types and mechanisms by which CD2AP dosage contributes to key pathological features AD. This review summarizes fundamental roles mammalian cells systems, discusses novel pathogenic focused on AD highlights necessity incorporating biological sex research. Finally, article draws important parallels between brain physiology based vascular molecular organization, links AD, suggests existence kidney-brain axis centered CD2AP.

Язык: Английский

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