Causal Contributions of Left Inferior and Medial Frontal Cortex to Semantic and Executive Control DOI Creative Commons
Sandra Martin, Matteo Ferrante, Andrea Bruera

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

Abstract Semantic control guides the targeted and context-based retrieval from semantic memory. The overlap with dissociation domain-general executive in frontal lobe remains contentious. Here, we used transcranial magnetic stimulation (TMS) to probe functional relevance of left inferior gyrus (IFG) pre-supplementary motor area (pre-SMA) for control. Across four sessions, 24 participants received 1 Hz repetitive TMS each region individually, dual-site targeting both regions sequentially (IFG followed by pre-SMA), sham TMS. Participants then completed fluency, figural picture-naming tasks. Stimulation either broadly disrupted suggesting shared functionality. However, electric field modeling induced strength revealed distinct specializations: IFG was primarily associated control, as evidenced verbal fluency deficits, while pre-SMA played a role functions, affecting non-verbal cognitive flexibility (e.g., clustering switching during fluency). Notably, only impaired accuracy providing unique evidence successful compensation functions through or following single-site perturbation. These findings underscore multidimensionality suggest flexible task-dependent contribution processes, semantic-specific general resource. Furthermore, they highlight tightly interconnected network subserved pre-SMA, advancing our understanding neural basis functions.

Язык: Английский

Causal Contributions of Left Inferior and Medial Frontal Cortex to Semantic and Executive Control DOI Creative Commons
Sandra Martin, Matteo Ferrante, Andrea Bruera

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

Abstract Semantic control guides the targeted and context-based retrieval from semantic memory. The overlap with dissociation domain-general executive in frontal lobe remains contentious. Here, we used transcranial magnetic stimulation (TMS) to probe functional relevance of left inferior gyrus (IFG) pre-supplementary motor area (pre-SMA) for control. Across four sessions, 24 participants received 1 Hz repetitive TMS each region individually, dual-site targeting both regions sequentially (IFG followed by pre-SMA), sham TMS. Participants then completed fluency, figural picture-naming tasks. Stimulation either broadly disrupted suggesting shared functionality. However, electric field modeling induced strength revealed distinct specializations: IFG was primarily associated control, as evidenced verbal fluency deficits, while pre-SMA played a role functions, affecting non-verbal cognitive flexibility (e.g., clustering switching during fluency). Notably, only impaired accuracy providing unique evidence successful compensation functions through or following single-site perturbation. These findings underscore multidimensionality suggest flexible task-dependent contribution processes, semantic-specific general resource. Furthermore, they highlight tightly interconnected network subserved pre-SMA, advancing our understanding neural basis functions.

Язык: Английский

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