Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2

Frontiers in Medicine, Год журнала: 2020, Номер 7

Опубликована: Дек. 3, 2020

The explosion of the new coronavirus (SARS-CoV-2) pandemic has brought role angiotensin converting enzyme 2 (ACE2) back into scientific limelight. Since SARS-CoV-2 must bind ACE2 for entering host cells in humans, its expression and body localization are critical to track potential target organ this infection outline disease progression clinical outcomes. Here, we mapped physiological distribution, expression, activities discussed correlations mutal interactions with disparate symptoms present patients at level different organs. We highlighted that despite during ACE2-expressing organs may become direct targets, leading severe pathological manifestations, subsequent multiple failures, exact mechanism through which acts these is still heavily debated. Further efforts, also considering a personalized approach aimed consider specific patient differences mutual ACE2-SARS-CoV-2 long-term health effects associated COVID-19 currently mandatory.

Язык: Английский

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Pathophysiology of COVID-19: Mechanisms Underlying Disease Severity and Progression

Physiology, Год журнала: 2020, Номер 35(5), С. 288 - 301

Опубликована: Авг. 12, 2020

The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum clinical severity, ranging from asymptomatic to fatal. Although the and laboratory characteristics COVID-19 patients have been well characterized, pathophysiological mechanisms underlying severity progression remain unclear. This review highlights key that proposed contribute viral entry multisystem organ failure, as central role immune response in successful clearance or death.

Язык: Английский

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Abnormal Liver Tests in COVID‐19: A Retrospective Observational Cohort Study of 1,827 Patients in a Major U.S. Hospital Network

Hepatology, Год журнала: 2020, Номер 72(4), С. 1169 - 1176

Опубликована: Июль 29, 2020

Background and Aims The coronavirus‐19 disease (COVID‐19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 virus, is associated with significant morbidity mortality attributable to pneumonia, distress syndrome, multiorgan failure. Liver injury has been reported as a nonpulmonary manifestation of COVID‐19, but characterization liver test abnormalities their association clinical outcomes incomplete. Approach Results We conducted retrospective cohort study 1,827 patients confirmed COVID‐19 who were hospitalized within Yale‐New Haven Health System between March 14, 2020 April 23, 2020. Clinical characteristics, tests (aspartate aminotransferase [AST], alanine [ALT], alkaline phosphatase [ALP], total bilirubin [TBIL], albumin) at three time points (preinfection baseline, admission, peak hospitalization), hospitalization (severe intensive care unit [ICU] mechanical ventilation, death) analyzed. Abnormal commonly observed in both admission (AST 66.9%, ALT 41.6%, ALP 13.5%, TBIL 4.3%) 83.4%, 61.6%, 22.7%, 16.1%). Most abnormal had minimal elevations 1‐2× upper limit normal (ULN; AST 63.7%, 63.5%, 80.0%, 75.7%). A proportion these prehospitalization 25.9%, 38.0%, 56.8%, 44.4%). Multivariate analysis revealed an including ICU death; associations age, male sex, body mass index, diabetes mellitus also observed. Medications used treatment (lopinavir/ritonavir, hydroxychloroquine, remdesivir, tocilizumab) transaminase >5× ULN. Conclusions occur most may be poorer outcomes.

Язык: Английский

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IL-6–based mortality risk model for hospitalized patients with COVID-19

Journal of Allergy and Clinical Immunology, Год журнала: 2020, Номер 146(4), С. 799 - 807.e9

Опубликована: Июль 22, 2020

Язык: Английский

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Factors associated with disease severity and mortality among patients with COVID-19: A systematic review and meta-analysis

PLoS ONE, Год журнала: 2020, Номер 15(11), С. e0241541 - e0241541

Опубликована: Ноя. 18, 2020

Background Understanding the factors associated with disease severity and mortality in Coronavirus (COVID-19) is imperative to effectively triage patients. We performed a systematic review determine demographic, clinical, laboratory radiological COVID-19. Methods searched PubMed, Embase WHO database for English language articles from inception until May 8, 2020. included Observational studies direct comparison of clinical characteristics between a) patients who died those survived or b) severe without disease. Data extraction quality assessment were by two authors independently. Results Among 15680 literature search, 109 analysis. The risk was higher increasing age, male gender (RR 1.45, 95%CI 1.23–1.71), dyspnea 2.55, 1.88–2.46), diabetes 1.59, 1.41–1.78), hypertension 1.90, 1.69–2.15). Congestive heart failure (OR 4.76, 1.34–16.97), hilar lymphadenopathy 8.34, 2.57–27.08), bilateral lung involvement 4.86, 3.19–7.39) reticular pattern 5.54, 1.24–24.67) Clinically relevant cut-offs leukocytosis(>10.0 x10 9 /L), lymphopenia(< 1.1 elevated C-reactive protein(>100mg/L), LDH(>250U/L) D-dimer(>1mg/L) had odds greater mortality. Conclusion Knowledge identified our study may assist decision-making critical-care resource allocation

Язык: Английский

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Predictors of mortality in patients with coronavirus disease 2019: a systematic review and meta-analysis

BMC Infectious Diseases, Год журнала: 2021, Номер 21(1)

Опубликована: Июль 8, 2021

Abstract Background Coronavirus disease 2019 (COVID-19) is associated with a high mortality rate, especially in patients severe illness. We conducted systematic review and meta-analysis to assess the potential predictors of COVID-19. Methods PubMed, EMBASE, Cochrane Library, three electronic Chinese databases were searched from December 1, April 29, 2020. Eligible studies reporting COVID-19 identified. Unadjusted prognostic effect estimates pooled using random-effects model if data at least two available. Adjusted presented by qualitative analysis. Results Thirty-six observational identified, which 27 included meta-analysis. A total 106 risk factors tested, following important mortality: advanced age, male sex, current smoking status, preexisting comorbidities (especially chronic kidney, respiratory, cardio-cerebrovascular diseases), symptoms dyspnea, complications during hospitalization, corticosteroid therapy condition. Additionally, series abnormal laboratory biomarkers hematologic parameters, hepatorenal function, inflammation, coagulation, cardiovascular injury also fatal outcome. Conclusion identified These findings could help healthcare providers take appropriate measures improve clinical outcomes such patients.

Язык: Английский

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Coronavirus Disease 2019 as Cause of Viral Sepsis: A Systematic Review and Meta-Analysis*

Critical Care Medicine, Год журнала: 2021, Номер 49(12), С. 2042 - 2057

Опубликована: Июль 13, 2021

Coronavirus disease 2019 is a heterogeneous most frequently causing respiratory tract infection, which can induce failure and multiple organ dysfunction syndrome in its severe forms. The prevalence of coronavirus 2019-related sepsis still unclear; we aimed to describe this systematic review.

Язык: Английский

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Abnormal liver function tests predict transfer to intensive care unit and death in COVID‐19

Liver International, Год журнала: 2020, Номер 40(10), С. 2394 - 2406

Опубликована: Июнь 11, 2020

The pandemic of coronavirus disease 2019 (COVID-19) has emerged as a relevant threat for humans worldwide. Abnormality in liver function tests (LFTs) been commonly observed patients with COVID-19, but there is controversy on its clinical significance. aim this study was to assess the prevalence, characteristics and impact abnormal LFTs hospitalized, non-critically ill COVID-19.In multicentre, retrospective study, we collected data about 565 inpatients COVID-19. Data were at admission every 7 ± 2 days during hospitalization. primary outcome composite endpoint death or transfer intensive care unit (ICU).Upon 329 (58%) had abnormality. Patients more severe inflammation higher degree organ dysfunction than those without. During hospitalization, rate ICU (20% vs 8%; P < .001), acute kidney injury (22% 13%, = .009), need mechanical ventilation (14% 6%; .005) mortality (21% 11%; .004) In multivariate analysis, risk (OR 3.53; .001). 86 developed de novo abnormality, which associated use tocilizumab, lopinavir/ritonavir acetaminophen not clearly endpoint.LFTs abnormality common systemic inflammation, an independent predictor death.

Язык: Английский

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Prognostic factors in patients with diabetes hospitalized for COVID-19: Findings from the CORONADO study and other recent reports

Diabetes & Metabolism, Год журнала: 2020, Номер 46(4), С. 265 - 271

Опубликована: Май 21, 2020

Язык: Английский

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The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Фев. 23, 2022

Abstract The coronavirus disease 2019 (COVID-19) is a highly transmissible caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) that poses major threat to global public health. Although COVID-19 primarily affects system, causing pneumonia and distress in cases, it can also result multiple extrapulmonary complications. pathogenesis of damage patients with probably multifactorial, involving both direct effects SARS-CoV-2 indirect mechanisms associated host inflammatory response. Recognition features complications has clinical implications for identifying progression designing therapeutic strategies. This review provides an overview from immunological pathophysiologic perspectives focuses on potential targets management COVID-19.

Язык: Английский

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