Gut microbiome-brain-cirrhosis axis DOI Open Access
Maren L. Smith, James B. Wade, Jennifer T. Wolstenholme

и другие.

Hepatology, Год журнала: 2023, Номер 80(2), С. 465 - 485

Опубликована: Март 3, 2023

Cirrhosis is characterized by inflammation, degeneration, and fibrosis of liver tissue. Along with being the most common cause failure transplant, cirrhosis a significant risk factor for several neuropsychiatric conditions. The these HE, which cognitive ataxic symptoms, resulting from buildup metabolic toxins failure. However, patients also show significantly increased neurodegenerative diseases such as Alzheimer Parkinson diseases, mood disorders anxiety depression. In recent years, more attention has been played to communication between ways gut communicate each other central nervous system, way organs influence other’s function. This bidirectional come be known gut-liver-brain axis. microbiome emerged key mechanism affecting gut-liver, gut-brain, brain-liver communication. Clinical studies animal models have demonstrated patterns dysbiosis when present, both or without concomitant alcohol use disorder, provided compelling evidence that this influences mood-related behaviors. review, we summarized pathophysiological effects associated cirrhosis, links cirrhosis-associated disruption microbiome, current clinical preclinical modulation treatment

Язык: Английский

Efficacy and safety of fecal microbiota transplantation for the treatment of diseases other than Clostridium difficile infection: a systematic review and meta-analysis DOI Creative Commons
Jessica Green, Jessica A. Davis, Michael Berk

и другие.

Gut Microbes, Год журнала: 2020, Номер 12(1), С. 1854640 - 1854640

Опубликована: Ноя. 9, 2020

The intestinal microbiome has been identified as a key modifier for variety of health conditions. Fecal Microbiota Transplantation (FMT) emerged fast, safe, and effective means by which to modify the potentially treat Despite extensive research FMT CDI, there is lack clarity informed systematic synthesis data regarding safety efficacy other This review used PRISMA guidelines was prospectively registered with PROSPERO (CRD42018104243). In March 2020, search MEDLINE, EMBASE, PsycINFO conducted. We 26 eligible studies. A meta-analysis active Ulcerative Colitis (UC) showed that significantly improved rates clinical remission (OR = 3.634, 95% CI 1.940 6.808, I2 0%, p < .001), response 2.634, 1.441 4.815, 33%, .002) endoscopic 4.431, 1.901 10.324, .001). With respect Irritable Bowel Syndrome, no significant change in symptoms following (p .739). Hepatic disorders, metabolic syndrome, antibiotic-resistant organisms were conditions emerging on FMT. Serious adverse events (AE) more often reported control group participants (n 43) compared 26). There similar mild moderate AE both groups. Preliminary suggest well-tolerated efficacious treatment certain than evidence UC being most compelling.

Язык: Английский

Процитировано

116
Microbiota‐gut‐brain axis as a regulator of reward processes DOI
Rubén García‐Cabrerizo, Carina Carbia,

Kenneth J. O ́Riordan

и другие.

Journal of Neurochemistry, Год журнала: 2020, Номер 157(5), С. 1495 - 1524

Опубликована: Дек. 26, 2020

Abstract Our gut harbours trillions of microorganisms essential for the maintenance homeostasis and host physiology in health disease. In last decade, there has been a growing interest understanding bidirectional pathway communication between our microbiota central nervous system. With regard to reward processes is accumulating evidence from both animal human studies that this axis may be key factor gating valence. Focusing on mesocorticolimbic pathway, we will discuss how intestinal involved regulating brain functions, natural (i.e. eating, social or sexual behaviours) non‐natural reinforcers (drug addiction behaviours including those relevant alcohol, psychostimulants, opioids cannabinoids). We integrate preclinical clinical suggesting microbiota‐gut‐brain could implicated development disorders associated with alterations system it targeted as promising therapeutic strategy. image Cover Image issue: https://doi.org/10.1111/jnc.15065 .

Язык: Английский

Процитировано

106
Alcohol’s Impact on the Gut and Liver DOI Open Access
Keith Pohl, Prebashan Moodley, Ashwin Dhanda

и другие.

Nutrients, Год журнала: 2021, Номер 13(9), С. 3170 - 3170

Опубликована: Сен. 11, 2021

Alcohol is inextricably linked with the digestive system. It absorbed through gut and metabolised by hepatocytes within liver. Excessive alcohol use results in alterations to microbiome epithelial integrity. contributes important micronutrient deficiencies including short-chain fatty acids trace elements that can influence immune function lead liver damage. In some people, long-term misuse disease progressing from cirrhosis hepatocellular carcinoma, over half of all deaths chronic disease, a million globally per year. this review, we will describe effect on gut, structure, specific focus micronutrients areas for future research.

Язык: Английский

Процитировано

78
Gut-derived systemic inflammation as a driver of depression in chronic liver disease DOI Open Access
Victoria Kronsten, Thomas H. Tranah, Carmine M. Pariante

и другие.

Journal of Hepatology, Год журнала: 2021, Номер 76(3), С. 665 - 680

Опубликована: Ноя. 17, 2021

Язык: Английский

Процитировано

77
Encyclopedia of fecal microbiota transplantation: a review of effectiveness in the treatment of 85 diseases DOI Creative Commons
Yun Wang, Sheng Zhang, Thomas J. Borody

и другие.

Chinese Medical Journal, Год журнала: 2022, Номер unknown

Опубликована: Сен. 14, 2022

Fecal microbiota transplantation (FMT) has been used as a core therapy for treating dysbiosis-related diseases by remodeling gut microbiota. The methodology and technology improving FMT are stepping forward, mainly including washed (WMT), colonic transendoscopic enteral tubing (TET) delivery, purified Firmicutes spores from fecal matter. To improve the understanding of clinical applications FMT, we performed systematic literature review on published 2011 to 2021. Here, provided an overview reported benefits processing strategy using regulations global perspective. A total 782 studies were included final analysis. present profiled effectiveness all uses in 85 specific eight categories, infections, diseases, microbiota-gut-liver axis, microbiota-gut-brain metabolic oncology, hematological other diseases. Although many further controlled trials will be needed, dramatic increasing reports have shown promising future or beyond gut.

Язык: Английский

Процитировано

66
Translational Approaches with Antioxidant Phytochemicals against Alcohol-Mediated Oxidative Stress, Gut Dysbiosis, Intestinal Barrier Dysfunction, and Fatty Liver Disease DOI Creative Commons

Jacob W. Ballway,

Byoung‐Joon Song

Antioxidants, Год журнала: 2021, Номер 10(3), С. 384 - 384

Опубликована: Март 4, 2021

Emerging data demonstrate the important roles of altered gut microbiomes (dysbiosis) in many disease states peripheral tissues and central nervous system. Gut dysbiosis with decreased ratios Bacteroidetes/Firmicutes other changes are reported to be caused by various environmental factors, such as ethanol (e.g., alcohol drinking), Western-style high-fat diets, high fructose, etc. It is also genetic including polymorphisms epigenetic different individuals. dysbiosis, impaired intestinal barrier function, elevated serum endotoxin levels can observed human patients and/or experimental rodent models exposed these factors or certain states. However, leaky normalized through lifestyle alterations increased consumption healthy diets fruits vegetables containing kinds antioxidant phytochemicals. In this review, we describe mechanisms gut, endotoxemia, fatty liver a specific focus on alcohol-associated pathways. We mention translational approaches discussing benefits phytochemicals their metabolites against alcohol-mediated oxidative stress, dysfunction, disease.

Язык: Английский

Процитировано

56
Long-term Outcomes of Stool Transplant in Alcohol-associated Hepatitis—Analysis of Clinical Outcomes, Relapse, Gut Microbiota and Comparisons with Standard Care DOI
Cyriac Abby Philips, Rizwan Ahamed, S Rajesh

и другие.

Journal of Clinical and Experimental Hepatology, Год журнала: 2022, Номер 12(4), С. 1124 - 1132

Опубликована: Янв. 8, 2022

Язык: Английский

Процитировано

52
Fecal microbiota transplantation compared with prednisolone in severe alcoholic hepatitis patients: a randomized trial DOI
Apurva Pande, Shvetank Sharma, Vikas Khillan

и другие.

Hepatology International, Год журнала: 2022, Номер 17(1), С. 249 - 261

Опубликована: Дек. 5, 2022

Язык: Английский

Процитировано

51
Gut Microbiome Dysbiosis in Alcoholism: Consequences for Health and Recovery DOI Creative Commons

Andrew Whittier Day,

Carol A. Kumamoto

Frontiers in Cellular and Infection Microbiology, Год журнала: 2022, Номер 12

Опубликована: Март 3, 2022

Since the mid 1980’s, impact of gastrointestinal (GI) microbiome changes during alcohol use disorder has been an area significant interest. This work resulted in identification specific abundance certain members GI and role these play a variety related disorders ( i.e. alcoholic liver disease). Interestingly, some findings suggest possible for addiction or withdrawal. Unfortunately, there is gap knowledge this area. Here we describe differences non-alcoholic individuals discuss microbes on gut-brain axis, which could behaviors addiction). Understanding will potentially lead to development successful microbiome-targeted therapeutics help mitigate disorders.

Язык: Английский

Процитировано

43
Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice DOI Creative Commons
Jennifer T. Wolstenholme, Justin M. Saunders, Maren L. Smith

и другие.

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Окт. 19, 2022

Abstract Alcohol use disorder is a major cause of morbidity, which requires newer treatment approaches. We previously showed in randomized clinical trial that alcohol craving and consumption reduces after fecal transplantation. Here, to determine if this could be transmitted through microbial transfer, germ-free male C57BL/6 mice received stool or sterile supernatants collected from the participants pre-/post-fecal transplant. found colonized with post-fecal transplant but not reduced ethanol acceptance, intake preference versus pre-fecal mice. Microbial taxa were higher humans also associated lower murine preference. A majority differentially expressed genes (immune response, inflammation, oxidative stress epithelial cell proliferation) occurred intestine rather than liver prefrontal cortex. These findings suggest potential for therapeutically targeting gut microbiota microbial-intestinal interface alter gut-liver-brain axis reduce humans.

Язык: Английский

Процитировано

38