Hepatology,
Год журнала:
2023,
Номер
80(2), С. 465 - 485
Опубликована: Март 3, 2023
Cirrhosis
is
characterized
by
inflammation,
degeneration,
and
fibrosis
of
liver
tissue.
Along
with
being
the
most
common
cause
failure
transplant,
cirrhosis
a
significant
risk
factor
for
several
neuropsychiatric
conditions.
The
these
HE,
which
cognitive
ataxic
symptoms,
resulting
from
buildup
metabolic
toxins
failure.
However,
patients
also
show
significantly
increased
neurodegenerative
diseases
such
as
Alzheimer
Parkinson
diseases,
mood
disorders
anxiety
depression.
In
recent
years,
more
attention
has
been
played
to
communication
between
ways
gut
communicate
each
other
central
nervous
system,
way
organs
influence
other’s
function.
This
bidirectional
come
be
known
gut-liver-brain
axis.
microbiome
emerged
key
mechanism
affecting
gut-liver,
gut-brain,
brain-liver
communication.
Clinical
studies
animal
models
have
demonstrated
patterns
dysbiosis
when
present,
both
or
without
concomitant
alcohol
use
disorder,
provided
compelling
evidence
that
this
influences
mood-related
behaviors.
review,
we
summarized
pathophysiological
effects
associated
cirrhosis,
links
cirrhosis-associated
disruption
microbiome,
current
clinical
preclinical
modulation
treatment
The American Journal of Gastroenterology,
Год журнала:
2023,
Номер
118(8), С. 1457 - 1460
Опубликована: Апрель 11, 2023
INTRODUCTION:
We
investigated
the
effect
of
daily
oral
Lactobacillus
rhamnosus
GG
(LGG)
in
reducing
liver
injury/severity
and
drinking
patients
with
alcohol
use
disorder
moderately
severe
alcohol-associated
hepatitis.
METHODS:
Forty-six
male
female
individuals
moderate
hepatitis
(12
≤
model
for
end-stage
disease
score
<
20,
aged
21–67
years)
received
either
LGG
(n
=
24)
or
placebo
22).
Data
were
collected/assessed
at
baseline
1,
3,
6
months.
RESULTS:
treatment
was
associated
a
significant
reduction
injury
after
1
month.
Six
months
reduced
heavy
levels
to
social
abstinence
levels.
DISCUSSION:
an
improvement
both
drinking.
Biomedicines,
Год журнала:
2023,
Номер
11(11), С. 2930 - 2930
Опубликована: Окт. 30, 2023
The
human
gastrointestinal
tract
houses
a
diverse
array
of
probiotic
and
pathogenic
bacteria
any
alterations
in
this
microbial
composition
can
exert
significant
influence
on
an
individual’s
well-being.
It
is
well-established
that
imbalances
the
gut
microbiota
play
pivotal
role
development
liver
diseases.
In
light
this,
new
adjuvant
therapy
for
diseases
could
be
regulating
intestinal
microbiota.
Through
fecal
transplantation,
patients
whose
microbiomes
are
compromised
treated
with
stool
from
healthy
donors
attempt
to
restore
normal
microbiome
alleviate
their
symptoms.
A
review
cross-sectional
studies
case
reports
suggests
transplants
may
offer
effective
treatment
chronic
Adding
potential
emerging
therapy,
recent
research
has
indicated
transplantation
holds
promise
as
therapeutic
approach
specifically
cirrhosis.
By
introducing
range
beneficial
microorganisms
into
gut,
innovative
aims
address
often
observed
cirrhotic
patients.
While
further
validation
still
required,
these
preliminary
findings
highlight
impact
novel
targeted
method
managing
We
aimed
summarize
current
state
understanding
regarding
procedure,
cirrhosis,
well
explain
its
clinical
application
future
potential.
Journal of Clinical Medicine,
Год журнала:
2023,
Номер
12(4), С. 1683 - 1683
Опубликована: Фев. 20, 2023
A
growing
body
of
evidence
suggested
that
gut
microbiota
is
associated
with
liver
diseases
through
the
gut–liver
axis.
The
imbalance
could
be
correlated
occurrence,
development,
and
prognosis
a
series
diseases,
including
alcoholic
disease
(ALD),
non-alcoholic
fatty
(NAFLD),
viral
hepatitis,
cirrhosis,
primary
sclerosing
cholangitis
(PSC),
hepatocellular
carcinoma
(HCC).
Fecal
transplantation
(FMT)
seems
to
method
normalize
patient’s
microbiota.
This
has
been
traced
back
4th
century.
In
recent
decade,
FMT
highly
regarded
in
several
clinical
trials.
As
novel
approach
reconstruct
intestinal
microecological
balance,
used
treat
chronic
diseases.
Therefore,
this
review,
role
treatment
was
summarized.
addition,
relationship
between
explored
axis,
definition,
objectives,
advantages,
procedures
were
described.
Finally,
value
therapy
transplant
(LT)
recipients
briefly
discussed.
Hepatology,
Год журнала:
2023,
Номер
80(2), С. 465 - 485
Опубликована: Март 3, 2023
Cirrhosis
is
characterized
by
inflammation,
degeneration,
and
fibrosis
of
liver
tissue.
Along
with
being
the
most
common
cause
failure
transplant,
cirrhosis
a
significant
risk
factor
for
several
neuropsychiatric
conditions.
The
these
HE,
which
cognitive
ataxic
symptoms,
resulting
from
buildup
metabolic
toxins
failure.
However,
patients
also
show
significantly
increased
neurodegenerative
diseases
such
as
Alzheimer
Parkinson
diseases,
mood
disorders
anxiety
depression.
In
recent
years,
more
attention
has
been
played
to
communication
between
ways
gut
communicate
each
other
central
nervous
system,
way
organs
influence
other’s
function.
This
bidirectional
come
be
known
gut-liver-brain
axis.
microbiome
emerged
key
mechanism
affecting
gut-liver,
gut-brain,
brain-liver
communication.
Clinical
studies
animal
models
have
demonstrated
patterns
dysbiosis
when
present,
both
or
without
concomitant
alcohol
use
disorder,
provided
compelling
evidence
that
this
influences
mood-related
behaviors.
review,
we
summarized
pathophysiological
effects
associated
cirrhosis,
links
cirrhosis-associated
disruption
microbiome,
current
clinical
preclinical
modulation
treatment
