Cancer Letters, Год журнала: 2025, Номер unknown, С. 217475 - 217475
Опубликована: Янв. 1, 2025
Язык: Английский
Molecular Cancer, Год журнала: 2024, Номер 23(1)
Опубликована: Май 7, 2024
Abstract Breast cancer, the most frequent female malignancy, is often curable when detected at an early stage. The treatment of metastatic breast cancer more challenging and may be unresponsive to conventional therapy. Immunotherapy crucial for treating but its resistance a major limitation. tumor microenvironment (TME) vital in modulating immunotherapy response. Various microenvironmental components, such as cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), are involved TME modulation cause resistance. This review highlights role stromal microenvironment, including involvement CAF-TAM interaction, alteration metabolism leading failure, other latest strategies, high throughput genomic screening, single-cell spatial omics techniques identifying immune genes regulating emphasizes therapeutic approach overcome through CAF reprogramming, TAM polarization, metabolism, alterations.
Язык: Английский
Процитировано
41
Experimental Hematology and Oncology, Год журнала: 2024, Номер 13(1)
Опубликована: Апрель 12, 2024
Abstract Paradoxically, tumor development and progression can be inhibited promoted by the immune system. After three stages of editing, namely, elimination, homeostasis escape, cells are no longer restricted surveillance thus develop into clinical tumors. The mechanisms escape include abnormalities in antitumor-associated cells, selection for resistance to impaired transport T formation an immunosuppressive microenvironment. A population distinct immature myeloid myeloid-derived suppressor (MDSCs), mediate primarily exerting effects participating constitution microtumor environment. Clinical trials have found that levels MDSCs peripheral blood cancer patients strongly correlated with stage, metastasis prognosis. Moreover, animal experiments confirmed elimination inhibits growth some extent. Therefore, may become target immunotherapy many cancers, eliminating help improve response rate treatment patient survival. However, a clear definition specific mechanism involved lacking. In this paper, we review role different contexts. addition, discuss use these as targets immunotherapy. This not only contributes systematic comprehensive understanding essential system reactions against tumors but also provides information guide therapies targeting MDSCs.
Язык: Английский
Процитировано
37
Cancer and Metastasis Reviews, Год журнала: 2024, Номер 43(3), С. 1095 - 1116
Опубликована: Апрель 11, 2024
Abstract Tumor microenvironment (TME) has been demonstrated to play a significant role in tumor initiation, progression, and metastasis. Cancer-associated fibroblasts (CAFs) are the major component of TME exhibit heterogeneous properties their communication with cells. This heterogeneity CAFs can be attributed various origins, including quiescent fibroblasts, mesenchymal stem cells (MSCs), adipocytes, pericytes, endothelial cells, mesothelial Moreover, single-cell RNA sequencing identified diverse phenotypes CAFs, myofibroblastic (myCAFs) inflammatory (iCAFs) being most acknowledged, alongside newly discovered subtypes like antigen-presenting (apCAFs). Due these heterogeneities, exert multiple functions tumorigenesis, cancer stemness, angiogenesis, immunosuppression, metabolism, As result, targeted therapies aimed at TME, particularly focusing on rapidly developing, fueling promising future advanced tumor-targeted therapy.
Язык: Английский
Процитировано
27
Journal of Experimental & Clinical Cancer Research, Год журнала: 2025, Номер 44(1)
Опубликована: Янв. 31, 2025
Язык: Английский
Процитировано
2
Biomarker Research, Год журнала: 2022, Номер 10(1)
Опубликована: Авг. 16, 2022
Abstract Liver cancer is one of the most common malignant tumors worldwide, it ranked sixth in incidence and fourth mortality. According to distinct origin tumor cells, liver mainly divided into hepatocellular carcinoma (HCC) cholangiocarcinoma (CCA). Since cases are diagnosed at an advanced stage, prognosis poor. Tumor growth depends on dynamic interaction various cellular components microenvironment (TME). As abundant stroma, cancer-associated fibroblasts (CAFs) have been involved progression cancer. The interplay between CAFs immune or vascular endothelial cells TME through direct cell-to-cell contact indirect paracrine interaction, affects initiation development tumors. Additionally, not a homogeneous cell population Recently, single-cell sequencing technology has used help better understand diversity In this review, we update knowledge both HCC CCA, including their origins, chemoresistance, stemness induction, formation, role CAFs. Understanding context-dependent different subsets provides new strategies for precise treatment.
Язык: Английский
Процитировано
42
Journal of Hepatology, Год журнала: 2022, Номер 78(1), С. 217 - 228
Опубликована: Сен. 20, 2022
Язык: Английский
Процитировано
38
Journal of Hepatology, Год журнала: 2023, Номер 79(3), С. 867 - 875
Опубликована: Май 17, 2023
Язык: Английский
Процитировано
31
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Июнь 23, 2023
The emergence of immunotherapy has profoundly changed the treatment model for triple-negative breast cancer (TNBC). But heterogeneity this disease resulted in significant differences efficacy, and only some patients are able to benefit from therapeutic modality. With recent explosion studies on mechanism drug resistance, article will focus processes immune response; summarize evasion mechanisms TNBC into three categories: loss tumor-specific antigen, antigen presentation deficiency, failure initiate an together with aberrant activation a series immune-critical signaling pathways, we discuss how these activities jointly shape immunosuppressive landscape within tumor microenvironment. This review attempt elucidate molecular resistance TNBC, identify potential targets that may assist reversing lay foundation research identifying biomarkers predicting efficacy selection populations immunotherapy.
Язык: Английский
Процитировано
27
Journal of Biomedical Science, Год журнала: 2023, Номер 30(1)
Опубликована: Янв. 4, 2023
Extensive studies of the tumor microenvironment (TME) in last decade have reformed view cancer as a cell-centric disease. The microenvironment, especially termed "seed and soil" theory, has emerged key determinant development therapeutic resistance. TME mainly consists cells, stromal cells such fibroblasts, immune other noncellular components. Within TME, intimate communications among these components largely determine fate tumor. pivotal roles stroma, cancer-associated fibroblasts (CAFs), most common component within been revealed tumorigenesis, progression, response, immunity. A better understanding function sheds light on therapy. In this review, we summarize emerging factors, CAFs, drug resistance, immunity with an emphasis their functions epigenetic regulation. Moreover, importance regulation reshaping basic biological principles underpinning synergy between therapy immunotherapy will be further discussed.
Язык: Английский
Процитировано
25
Cancer Cell International, Год журнала: 2023, Номер 23(1)
Опубликована: Дек. 1, 2023
Abstract High recurrence and metastasis rates poor prognoses are the major challenges of current cancer therapy. Mounting evidence suggests that stem cells (CSCs) play an important role in development, chemoradiotherapy resistance, recurrence, metastasis. Therefore, targeted CSC therapy has become a new strategy for solving problems recurrence. Since properties CSCs regulated by specific tumour microenvironment, so-called niche, which targets crosstalk between their niches, is vital our pursuit therapeutic opportunities to prevent from recurring. In this review, we aim highlight factors within niche have roles regulating properties, including extracellular matrix (ECM), stromal (e.g., associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), mesenchymal (MSCs)), physiological changes inflammation, hypoxia, angiogenesis). We also discuss recent progress regarding therapies targeting elucidate developments more effective strategies eliminate cancer.
Язык: Английский
Процитировано
24