Seminars in Liver Disease,
Год журнала:
2023,
Номер
43(03), С. 351 - 366
Опубликована: Авг. 1, 2023
The
COVID-19
pandemic
has
resulted
in
significant
worldwide
morbidity
and
mortality.
In
this
review,
we
examine
the
intricate
relationships
between
liver
diseases.
While
respiratory
manifestations
of
are
well
known,
its
impact
consequences
patients
with
diseases
remain
an
area
ongoing
investigation.
can
induce
injury
through
various
mechanisms
is
associated
higher
mortality
individuals
preexisting
chronic
disease.
Mortality
increases
severity
disease
level
care
required.
outcomes
autoimmune
hepatitis
unclear,
whereas
transplant
recipients
more
likely
to
experience
symptomatic
but
have
comparable
general
population.
Despite
suboptimal
immunological
response,
vaccinations
safe
effective
disease,
although
cases
hepatitis-like
syndrome
been
reported.
conclusion,
implications
diseases;
early
recognition
treatments
important
for
improving
patient
outcomes.
Current Opinion in Gastroenterology,
Год журнала:
2024,
Номер
40(3), С. 119 - 125
Опубликована: Фев. 14, 2024
Purpose
of
review
The
rapid
rollout
and
uptake
novel
coronavirus
disease
2019
(COVID-19)
vaccines
has
been
accompanied
by
a
small
yet
noticeable
accumulation
reports
liver
injury
occurring
after
vaccination.
This
describes
the
present
evidence
surrounding
COVID-19
vaccine-induced
(VILI).
Recent
findings
Liver
vaccine
often
presents
clinically
similar
to
autoimmune
hepatitis,
with
positive
autoantibodies
portal
lobular
inflammatory
infiltrate
varying
degrees
necrosis
on
biopsy.
overwhelming
majority
patients
recover,
spontaneously
or
limited
course
immunosuppression.
overall
incidence
this
phenomenon
appears
be
exceedingly
low.
Summary
Providers
should
remain
vigilant
for
ongoing
VILI
feel
reassured
low
high
likelihood
recovery.
Ongoing
genetic
histological
study,
as
well
longer-term
follow-up
presently
identified
cases,
will
shed
further
light
clinical
entity
VILI.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 18, 2024
Abstract
Background
Cirrhosis
has
been
pointed
out
as
a
clinical
entity
that
leads
to
worse
prognosis
in
COVID-19
patients.
However,
this
concept
is
controversial
the
literature.
We
aimed
evaluate
outcomes
by
comparing
patients
with
cirrhosis
those
without
Brazilian
cohort.
Methods
Data
from
20,164
inpatients
were
collected
41
hospitals
Brazil
between
March
September
2020
and
2021
August
2022.
compared
117
632
matched
controls.
A
propensity
score
model
was
used
adjust
for
potential
confounding
variables,
incorporating
some
predictors:
age,
sex
at
birth,
number
of
comorbidities,
hospital
admission,
whether
it
an
in-hospital
manifestation
admission
year.
Closeness
defined
being
within
0.16
standard
deviations
logit
score.
Results
The
median
age
61
(IQR
50–70)
years-old,
63.4%
men.
There
no
significant
differences
self-reported
symptoms.
Patients
had
lower
hemoglobin
levels
(10.8
vs
13.1
g/dl),
platelets
(127,000
200,000
cells/mm3),
leukocytes
counts,
well
C-reactive
protein
(63.0
76.0
p
=
0.044)
when
controls.They
also
higher
mortality
controls
(51.3%
21.7%,
<
0.001).
They
frequencies
intensive
care
unit
38.0%,
0.007),
invasive
mechanical
ventilation
(43.9%
26.6%,
0.001),
dialysis
(17.9%
11.1%,
0.038),
septic
shock
(23.9%
14.9%;
0.015)
institution
palliative
(19.7%
7.4%;
Conclusions
This
study
shown
significantly
incidence
severe
outcomes,
frequency
Our
findings
underscore
need
these
receive
particular
attention
healthcare
teams
allocated
resources.
GE Portuguese Journal of Gastroenterology,
Год журнала:
2023,
Номер
31(5), С. 325 - 337
Опубликована: Ноя. 15, 2023
Three
years
after
the
beginning
of
SARS-CoV-2
pandemic,
safety
and
efficacy
COVID-19
vaccination
in
liver
cirrhosis
(LC)
patients
remain
controversial.
We
aimed
to
study
safety,
immunological,
clinical
responses
LC
vaccination.
Hepatology,
Год журнала:
2023,
Номер
78(4), С. E78 - E79
Опубликована: Июль 17, 2023
Ge,
Jin;
Digitale,
Jean
C.;
Pletcher,
Mark
J.;
Lai,
Jennifer
for
the
N3C
Consortium
Collaborators
Chute,
Christopher
G.;
Harper,
Jeremy
R.;
Gabriel,
Davera;
Haendel,
Melissa
A.;
Pfaff,
Emily;
Leese,
Peter
Author
Information
Hepatology,
Год журнала:
2023,
Номер
78(4), С. E76 - E77
Опубликована: Июль 17, 2023
1Department
of
Paediatric
Genetics,
Endocrinology
and
Metabolism,
Chengdu
Women's
Children's
Central
Hospital,
School
Medicine,
University
Electronic
Science
Technology
China,
Chengdu,
China
2Division
Thoracic
Tumor
Multimodality
Treatment
Department
Radiation
Oncology,
Cancer
Center,
West
Sichuan
University,
Data
availability
statement:
The
data
that
support
the
findings
this
study
are
all
included
in
article.
Yue
Hu
Zheng
Li:
Contributed
equally
as
co-first
authors.
Correspondence
Xinran
Cheng,
Riyue
Road
1617#,
Qingyang
District,
610073,
China.
Email:
[email
protected]
Seminars in Liver Disease,
Год журнала:
2023,
Номер
43(03), С. 351 - 366
Опубликована: Авг. 1, 2023
The
COVID-19
pandemic
has
resulted
in
significant
worldwide
morbidity
and
mortality.
In
this
review,
we
examine
the
intricate
relationships
between
liver
diseases.
While
respiratory
manifestations
of
are
well
known,
its
impact
consequences
patients
with
diseases
remain
an
area
ongoing
investigation.
can
induce
injury
through
various
mechanisms
is
associated
higher
mortality
individuals
preexisting
chronic
disease.
Mortality
increases
severity
disease
level
care
required.
outcomes
autoimmune
hepatitis
unclear,
whereas
transplant
recipients
more
likely
to
experience
symptomatic
but
have
comparable
general
population.
Despite
suboptimal
immunological
response,
vaccinations
safe
effective
disease,
although
cases
hepatitis-like
syndrome
been
reported.
conclusion,
implications
diseases;
early
recognition
treatments
important
for
improving
patient
outcomes.
