A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation

Cell, Год журнала: 2021, Номер 184(12), С. 3222 - 3241.e26

Опубликована: Май 17, 2021

Язык: Английский

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Gamma rhythm communication between entorhinal cortex and dentate gyrus neuronal assemblies

Science, Год журнала: 2021, Номер 372(6537)

Опубликована: Апрель 1, 2021

Brain region coordination in learning Gamma-frequency oscillations have been hypothesized as a physiological mechanism of interregional communication the brain. However, until now, all supporting data correlational and thus indirect. Fernández-Ruiz et al. examined gamma-frequency activity spike coupling between entorhinal cortex hippocampal dentate gyrus during after selective perturbation timing. They observed an integrated neuron, gamma-band, task-specific organization cortex–hippocampal circuits. These demonstrate that specific, projected oscillation patterns dynamically engage functionally related cell assemblies across brain regions manner. Science , this issue p. eabf3119

Язык: Английский

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Disrupted Place Cell Remapping and Impaired Grid Cells in a Knockin Model of Alzheimer's Disease

Neuron, Год журнала: 2020, Номер 107(6), С. 1095 - 1112.e6

Опубликована: Июль 21, 2020

Язык: Английский

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The Neuropsychology of Anxiety

Oxford University Press eBooks, Год журнала: 2024, Номер unknown

Опубликована: Май 7, 2024

Abstract The Neuropsychology of Anxiety first appeared in 1982 as the volume Oxford Psychology Series, and it quickly established itself classic work on subject. It second edition (appearing 2000) have been cited at a steadily increasing rate passing 500/year 2017. field has continued to expand last quarter century necessitating this third edition. This completely updated revised (with many figures converted colour) retains original core concepts while expanding often simplifying details. includes new chapter prefrontal cortex, which integrates frontal hippocampal views anxiety an extensively modified personality providing basis for further developments Reinforcement Sensitivity Theory. book is essential postgraduate students researchers experimental psychology neuroscience, well all clinical psychologists psychiatrists.

Язык: Английский

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Assessments of dentate gyrus function: discoveries and debates

Nature reviews. Neuroscience, Год журнала: 2023, Номер 24(8), С. 502 - 517

Опубликована: Июнь 14, 2023

Язык: Английский

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The homogenous hippocampus: How hippocampal cells process available and potential goals

Progress in Neurobiology, Год журнала: 2024, Номер 240, С. 102653 - 102653

Опубликована: Июль 2, 2024

We present here a view of the firing patterns hippocampal cells that is contrary, both functionally and anatomically, to conventional wisdom. argue hippocampus responds efference copies goals encoded elsewhere; it uses these detect resolve conflict or interference between in general. While can involve space, do not encode spatial (or other special types of) memory, as such. also transverse circuits operate an essentially homogeneous way along its length. The apparently different functions parts (e.g. memory retrieval versus anxiety) result from (situational/motivational) inputs on which those perform same fundamental computational operations. On this view, key role iterative adjustment, via Papez-like circuits, synaptic weights cell assemblies elsewhere.

Язык: Английский

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Egocentric and allocentric representations of space in the rodent brain

Current Opinion in Neurobiology, Год журнала: 2019, Номер 60, С. 12 - 20

Опубликована: Дек. 2, 2019

Язык: Английский

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Convergent Projections from Perirhinal and Postrhinal Cortices Suggest a Multisensory Nature of Lateral, but Not Medial, Entorhinal Cortex

Cell Reports, Год журнала: 2019, Номер 29(3), С. 617 - 627.e7

Опубликована: Окт. 1, 2019

The current model of the organization medial temporal lobe (MTL) episodic memory system assumes that two functionally different "where" and "what" pathways enter MTL as parallel parahippocampal cortex (PHC)-medial entorhinal (MEC) perirhinal (PER)-lateral (LEC) streams, respectively. With use tract tracing in vitro electrophysiological recordings, we show that, rat LEC, all main principal neuron types layer II receive convergent inputs from PER postrhinal (POR), homologous to PHC primates. Projections MEC POR are much less prominent than previously assumed. These findings thus challenge prevailing concept LEC defined by PHC/POR, Our point multimodal integrative structure whose unique set external sensory-derived allows its network represent a continuously fluctuating extrinsic environment.

Язык: Английский

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Re-emphasizing early Alzheimer’s disease pathology starting in select entorhinal neurons, with a special focus on mitophagy

Ageing Research Reviews, Год журнала: 2021, Номер 67, С. 101307 - 101307

Опубликована: Фев. 21, 2021

The entorhinal-hippocampal system contains distinct networks subserving declarative memory. This is selectively vulnerable to changes of ageing and pathological processes. entorhinal cortex (EC) a pivotal component this memory since it serves as the interface between neocortex hippocampus. EC heavily affected by proteinopathies Alzheimer's disease (AD). These appear in stereotypical spatiotemporal manner include increased levels intracellular amyloid-beta Aβ (iAβ), parenchymal deposition plaques, neurofibrillary tangles (NFTs) containing abnormally processed Tau. Increased iAβ formation NFTs are seen very early on population neurons belonging layer II (EC LII), recent evidence leads us believe that made up highly energy-demanding reelin-positive (RE+) projection neurons. Mitochondria fundamental energy supply, metabolism, plasticity Evidence from AD postmortem brain tissues supports notion mitochondrial dysfunction one initial events AD, likely take place RE + LII Here we review discuss these notions, anchored anatomy formulate hypothesis attempting explain vulnerability NFTs. We attempt link impaired clearance signaling involving both apolipoprotein 4 reelin, argue for their relevance specifically during prodromal stages AD. future studies interactions holds promise advance our understanding etiology provide new ideas drug development.

Язык: Английский

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Extensive Cortical Connectivity of the Human Hippocampal Memory System: Beyond the “What” and “Where” Dual Stream Model

Cerebral Cortex, Год журнала: 2021, Номер 31(10), С. 4652 - 4669

Опубликована: Апрель 14, 2021

Abstract The human hippocampus is involved in forming new memories: damage impairs memory. dual stream model suggests that object “what” representations from ventral temporal cortex project to the via perirhinal and then lateral entorhinal cortex, spatial “where” dorsal parietal parahippocampal gyrus medial cortex. can associate these inputs form episodic memories of what happened where. Diffusion tractography was used reveal direct connections hippocampal system areas humans. This provides evidence has extensive cortical connections, with bypass connect pole, posterior retrosplenial cingulate even early sensory areas. are less hierarchical segregated than model. a foundation for conceptualization how memory connects cerebral operates One implication prehippocampal such as TF TH subregions cortices may implement specialized computations benefit streams.

Язык: Английский

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