The rapid developmental rise of somatic inhibition disengages hippocampal dynamics from self-motion

eLife, Год журнала: 2022, Номер 11

Опубликована: Июль 20, 2022

Early electrophysiological brain oscillations recorded in preterm babies and newborn rodents are initially mostly driven by bottom-up sensorimotor activity only later can detach from external inputs. This is a hallmark of most developing areas, including the hippocampus, which, adult brain, functions integrating inputs onto internal dynamics. Such developmental disengagement likely fundamental step for proper development cognitive models. Despite its importance, timeline circuit basis this remain unknown. To address issue, we have investigated daily evolution CA1 dynamics underlying circuits during first two postnatal weeks mouse using two-photon calcium imaging non-anesthetized pups. We show that week ends with an abrupt shift representation self-motion CA1. Indeed, pyramidal cells switch activated to inhibited self-generated movements at end week, whereas majority GABAergic neurons positively modulated throughout period. rapid occurs within 2 days follows anatomical functional surge local somatic innervation. The observed change consistent two-population model undergoing strengthening inhibition. propose transition inaugurates emergence hippocampal

Язык: Английский

---

Sensorimotor foundations of speech perception in infancy

Trends in Cognitive Sciences, Год журнала: 2023, Номер 27(8), С. 773 - 784

Опубликована: Июнь 10, 2023

Язык: Английский

---

Extrinsic control of the early postnatal CA1 hippocampal circuits

Neuron, Год журнала: 2023, Номер 111(6), С. 888 - 902.e8

Опубликована: Янв. 5, 2023

Язык: Английский

---

Preoperative recovery sleep ameliorates postoperative cognitive dysfunction aggravated by sleep fragmentation in aged mice by enhancing EEG delta-wave activity and LFP theta oscillation in hippocampal CA1

Brain Research Bulletin, Год журнала: 2024, Номер 211, С. 110945 - 110945

Опубликована: Апрель 10, 2024

Sleep fragmentation (SF) is a common sleep problem experienced during the perioperative period by older adults, and associated with postoperative cognitive dysfunction (POCD). Increasing evidence indicates that delta-wave activity non-rapid eye movement (NREM) involved in sleep-dependent memory consolidation hippocampal theta oscillations are related to spatial exploratory memory. Recovery (RS), self-regulated state of homeostasis, enhances power performance sleep-deprived mice. However, it remains unclear whether RS therapy has positive effect on changes following SF mouse models. Therefore, this study aimed explore preoperative can alleviate deficits aged mice SF. A model 24-h combined laparotomy-induced POCD was established 18-month-old Aged were treated 6-h surgery, respectively. The hippocampus-dependent function investigated using behavioral tests, electroencephalography (EEG), local field potential (LFP), magnetic resonance imaging, neuromorphology. Mice underwent surgery exhibited severe impairment; impaired could be alleviated treatment. In addition, increased NREM sleep; enhanced EEG LFP oscillation CA1; improved perfusion, microstructural integrity, neuronal damage. Taken together, these results provide may ameliorate severity aggravated enhancing delta slow-wave oscillation, ameliorating reduction regional cerebral blood flow white matter microstructure integrity hippocampus.

Язык: Английский

---

cFOS as a biomarker of activity maturation in the hippocampal formation

Frontiers in Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Июль 13, 2023

We explored the potential for cFOS expression as a marker of functional development “resting-state” waking activity in extended network hippocampus and entorhinal cortex. examined sleeping awake mice at (P)ostnatal days 5, 9, 13, 17 well adulthood. find that is state-dependent even 5 old, with reliable staining occurring only mice. Even during waking, was rare weak P5. The septal nuclei, cortex layer (L)2, anterodorsal thalamus were exceptional they had robust P5 similar to or greater than Significant also observed dentate gyrus, L6, postsubiculum L4-6, ventral subiculum, supramammillary nucleus, posterior hypothalamic nucleus. these regions grew stronger age, new added progressively P9 P13 by which point overall pattern many qualitatively adult. Six regions—CA1, dorsal L2-3, reuniens perirhinal postrhinal cortices—were very late developing, mostly achieving adult levels after P17. Our findings support number developmental principles. First, early spontaneous patterns induced muscle twitches sleep do not induce hippocampal network. Second, follows progressive activation along trisynaptic circuit, rather birth date cellular maturation. Third, we reveal components egocentric head-direction theta-rhythm circuits earliest active forebrain. results suggest may provide sensitive biomarker formation development, particularly regard attainment normal state synchronizing rhythms such theta gamma.

Язык: Английский

---

Impact of Yoga Versus Memory Enhancement Training on Hippocampal Connectivity in Older Women at Risk for Alzheimer’s Disease

Journal of Alzheimer s Disease, Год журнала: 2023, Номер 95(1), С. 149 - 159

Опубликована: Июль 19, 2023

Background: Yoga may be an ideal early intervention for those with modifiable risk factors Alzheimer’s disease (AD) development. Objective: To examine the effects of Kundalini yoga (KY) training versus memory enhancement (MET) on resting-state connectivity hippocampal subregions in women subjective decline and cardiovascular AD. Methods: Participants comprised who participated a parent randomized controlled trial (NCT03503669) 12-weeks KY MET completed pre- post-intervention magnetic resonance imaging scans (yoga: n = 11, age 61.45±6.58 years; MET: 64.55±6.41 years). Group differences parcellated (Cole-anticevic atlas) changes (post- minus pre-intervention) were evaluated by partial least squares analysis, controlling age. Correlations between perceived stress frequency forgetting (assessed questionnaires) also evaluated. Results: A left anterior subregion assigned to default mode network (DMN) Cole-anticevic atlas showed greater increases largely ventral visual stream regions than ( p < 0.001), which associations lower 0.05). Several posterior sensory-based networks DMN frontoparietal Conclusion: better target stress-related connectivity, whereas sensory-integration supporting reliability, factors.

Язык: Английский

---

Literature Cases Summarized Based on Their Polysomnographic Findings in Rett Syndrome

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(6), С. 3422 - 3422

Опубликована: Март 14, 2022

Rett syndrome (RTT) is a severe and rare neurodevelopmental disorder affecting mostly girls. In RTT, an impaired sleep pattern supportive criterion for the diagnosis, yet little known regarding structure respiratory events. Aiming to delineate by aggregating RTT case (series) data from published polysomnographic studies, seventy-four cases were collected eleven studies up until 6 February 2022 (PROSPERO: CRD 42020198099). We compared within stratifications typically developing population. MECP2 demonstrated shortened total time (TST) with increased stage N3 decreased REM sleep. CDKL5 mutations, TST was longer they spent more in N1 but less than those affected mutations Sleep-disordered breathing confirmed abnormal apnea/hypopnea index of 11.92 ± 23.67/h these aggregated cases. No association chronological age found. macrostructure versus showed differences, particularly N3. A propensity reduction Aberrant cycling, possibly characterized poor ‘on switch’ preponderance slow high-voltage sleep, proposed.

Язык: Английский

---

Infant motor development predicts the dynamics of movement during sleep

Infancy, Год журнала: 2022, Номер 28(2), С. 367 - 387

Опубликована: Дек. 1, 2022

Abstract The characteristics of infant sleep change over the first year. Generally, infants wake and move less at night as they grow older. However, acquisition new motor skills leads to temporary increases in waking movement night. Indeed, sleep‐dependent is important for sensorimotor development. Nevertheless, little known about how during changes accrue locomotor experience. current study investigated whether were predicted by infants' walking Seventy‐eight wore an actigraph measure physical activity sleep. Parents reported when their walked across a room >10 feet without stopping or falling. Infants midst skill had worse than age‐group estimate. with more walk experience temporally sporadic steeper hourly increase course Ongoing consolidation may alter state‐dependent memory consolidation. We propose model whereby gross reflect movement‐dependent

Язык: Английский

---

Activity in developing prefrontal cortex is shaped by sleep and sensory experience

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2022, Номер unknown

Опубликована: Авг. 3, 2022

ABSTRACT In developing rats, behavioral state exerts a profound modulatory influence on neural activity throughout the sensorimotor system, including primary motor cortex (M1). We hypothesized that similar state-dependent modulation occurs in higher-order cortical areas with which M1 forms functional connections. Here, using 8- and 12-day-old rats cycling freely between sleep wake, we record M1, secondary (M2), medial prefrontal (mPFC). At both ages all three areas, increased during active (AS) compared wake. Regardless of state, M2 mPFC periods when limbs were moving. This movement-related mPFC, like is driven by sensory feedback. Our results, diverge from those previous studies anesthetized pups, demonstrate AS-dependent responsivity extend to cortex. These findings expand range factors shaping activity-dependent development areas.

Язык: Английский

---

The rapid developmental rise of somatic inhibition disengages hippocampal dynamics from self-motion

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2021, Номер unknown

Опубликована: Июнь 9, 2021

ABSTRACT Early electrophysiological brain oscillations recorded in preterm babies and newborn rodents are initially mostly ignited by bottom-up sensorimotor activity only later can detach from external inputs. This is a hallmark of most developing areas including the hippocampus, which adult brain, functions integrating inputs onto internal dynamics. Such developmental disengagement likely fundamental step for proper development cognitive models. Despite its importance, timeline circuit basis this remain unknown. To address issue, we have investigated daily evolution CA1 dynamics underlying circuits during first two postnatal weeks mouse using two-photon calcium imaging non-anesthetized pups. We show that week ends with an abrupt shift representation self-motion CA1. Indeed, pyramidal cells switch activated to inhibited self-generated movements at end whereas majority GABAergic neurons positively modulated throughout period. rapid occurs within days follows anatomical functional surge local somatic innervation. The observed change consistent two-population model undergoing strengthening inhibition. propose transition inaugurates emergence

Язык: Английский

---