Flow-to-Flow Technology: Amide Formation in the Absence of Traditional Coupling Reagents Using DPDTC

ACS Sustainable Chemistry & Engineering, Год журнала: 2025, Номер 13(18), С. 6646 - 6655

Опубликована: Апрель 29, 2025

Reported herein is the use of a recyclable coupling agent, 2,2'-dipyridyldithiocarbonate (DPDTC), that generates isolable thioesters in plug flow reactor (PFR). If not isolated, can be reintroduced directly into PFR, along with amines, to generate amides "flow-to-flow" sense. Both electron-rich and -poor aromatic acids, as well sterically hindered aliphatic are efficiently coupled variety including formation Weinreb peptides, high yields.

Язык: Английский

Iodide assisted synthesis of amides on carbon electrode: application to N,N-diethylaminoethyl amide derivatives

Chemical Papers, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

Язык: Английский