Gut microbiota in neurological diseases: Melatonin plays an important regulatory role
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
174, С. 116487 - 116487
Опубликована: Март 21, 2024
Melatonin
is
a
highly
conserved
molecule
produced
in
the
human
pineal
gland
as
hormone.
It
known
for
its
essential
biological
effects,
such
antioxidant
activity,
circadian
rhythm
regulator,
and
immunomodulatory
effects.
The
gut
one
of
primary
sources
melatonin.
microbiota
helps
produce
melatonin
from
tryptophan,
has
been
shown
to
have
beneficial
effect
on
barrier
function
microbial
population.
Dysbiosis
intestinal
associated
with
bacterial
imbalance
decreased
metabolites,
including
In
this
way,
low
levels
may
be
related
several
diseases.
both
preventive
therapeutic
effects
against
various
conditions,
neurological
diseases
Alzheimer's
disease,
Parkinson's
multiple
sclerosis.
This
review
was
aimed
discuss
role
body,
describe
possible
relationship
between
production,
well
potential
Язык: Английский
Role of CRISPR-Cas systems and anti-CRISPR proteins in bacterial antibiotic resistance
Heliyon,
Год журнала:
2024,
Номер
10(14), С. e34692 - e34692
Опубликована: Июль 1, 2024
The
emergence
and
development
of
antibiotic
resistance
in
bacteria
is
a
serious
threat
to
global
public
health.
Antibiotic
genes
(ARGs)
are
often
located
on
mobile
genetic
elements
(MGEs).
They
can
be
transferred
among
by
horizontal
gene
transfer
(HGT),
leading
the
spread
drug-resistant
strains
treatment
failure.
CRISPR
(clustered
regularly
interspaced
short
palindromic
repeats)-Cas
(CRISPR-associated
genes)
one
many
strategies
have
developed
under
long-term
selection
pressure
restrict
HGT.
CRISPR-Cas
systems
exist
about
half
bacterial
genomes
play
significant
role
limiting
resistance.
On
other
hand,
bacteriophages
MGEs
encode
wide
range
anti-CRISPR
proteins
(Acrs)
counteract
immunity
system.
Acrs
could
decrease
system's
activity
against
phages
facilitate
acquisition
ARGs
virulence
traits
for
bacteria.
This
review
aimed
assess
relationship
between
with
We
also
highlighted
technology
control
prevent
antibacterial
system
target
nucleic
acid
sequences
high
accuracy
reliability;
therefore,
it
has
become
novel
editing
therapy
tool
CRISPR-based
approaches
may
pave
way
developing
smart
antibiotics,
which
eliminate
multidrug-resistant
(MDR)
distinguish
pathogenic
beneficial
microorganisms.
Additionally,
engineered
gene-containing
combination
antibiotics
used
as
cutting-edge
approach
reduce
Язык: Английский
Integrative metagenomics and metabolomics reveal age-associated gut microbiota and metabolite alterations in a hamster model of COVID-19
Gut Microbes,
Год журнала:
2025,
Номер
17(1)
Опубликована: Апрель 2, 2025
Aging
is
a
key
contributor
of
morbidity
and
mortality
during
acute
viral
pneumonia.
The
potential
role
age-associated
dysbiosis
on
disease
outcomes
still
elusive.
In
the
current
study,
we
used
high-resolution
shotgun
metagenomics
targeted
metabolomics
to
characterize
SARS-CoV-2-associated
changes
in
gut
microbiota
from
young
(2-month-old)
aged
(22-month-old)
hamsters,
valuable
model
COVID-19.
We
show
that
age-related
dysfunctions
are
linked
severity
long-term
sequelae
older
hamsters.
Our
data
also
reveal
age-specific
composition
metabolic
activity
both
phase
(day
7
post-infection,
D7)
recovery
(D22)
infection.
Aged
hamsters
exhibited
most
notable
shifts
plasma
profiles.
Through
an
integrative
analysis
metagenomics,
metabolomics,
clinical
data,
identified
significant
associations
between
bacterial
taxa,
metabolites
markers
group.
On
D7
(high
load
lung
epithelial
damage)
D22
(body
weight
loss
fibrosis),
numerous
amino
acids,
acid-related
molecules,
indole
derivatives
were
found
correlate
with
markers.
particular,
persistent
decrease
phenylalanine,
tryptophan,
glutamic
acid,
indoleacetic
acid
animals
positively
correlated
poor
body
and/or
fibrosis
by
D22.
younger
several
taxa
(Eubacterium,
Oscillospiraceae,
Lawsonibacter)
(carnosine
cis-aconitic
acid)
associated
mild
outcomes.
These
findings
support
need
for
microbiome-targeting
strategies
more
effectively
manage
pneumonia
Язык: Английский
Effects of pectin-type polysaccharides derived from Houttuynia cordata on the intestinal immune system in native C3H/HeN mice
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142995 - 142995
Опубликована: Апрель 1, 2025
Язык: Английский
The Relationship Between Gut Microbiota and Preterm Premature Rupture of Membranes: Mechanisms of Action and Clinical Applications
Microbial Pathogenesis,
Год журнала:
2025,
Номер
205, С. 107673 - 107673
Опубликована: Май 6, 2025
Язык: Английский
Integrative metagenomics and metabolomics reveal age-associated gut microbiota and metabolite alterations in experimental COVID-19
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 6, 2024
Abstract
Aging
is
a
key
contributor
of
morbidity
and
mortality
during
acute
viral
pneumonia.
The
potential
role
age-associated
dysbiosis
on
disease
outcomes
still
elusive.
In
the
current
study,
we
used
high-resolution
shotgun
metagenomics
targeted
metabolomics
to
characterize
SARS-CoV-2-associated
changes
in
gut
microbiota
from
young
(2-month-old)
aged
(22-month-old)
hamsters,
valuable
model
COVID-19.
We
show
that
age-related
dysfunctions
are
linked
severity
long-term
sequelae
older
hamsters.
Our
data
also
reveal
age-specific
composition
metabolic
activity
both
phase
(day
7
post-infection,
D7)
recovery
(D22)
infection.
Aged
hamsters
exhibited
most
notable
shifts
plasma
profiles.
Through
an
integrative
analysis
metagenomics,
metabolomics,
clinical
data,
identified
significant
associations
between
bacterial
taxa,
metabolites
markers
group.
On
D7
(high
load
lung
epithelial
damage)
D22
(body
weight
loss
fibrosis),
numerous
amino
acids,
acid-related
molecules,
indole
derivatives
were
found
correlate
with
markers.
particular,
persistent
decrease
phenylalanine,
tryptophan,
glutamic
acid,
indoleacetic
acid
animals
positively
correlated
poor
body
and/or
fibrosis
by
D22.
younger
several
taxa
(
Eubacterium
,
Oscillospiraceae
Lawsonibacter
)
(carnosine
cis-aconitic
acid)
associated
mild
outcomes.
These
findings
support
need
for
microbiome-targeting
strategies
more
effectively
manage
pneumonia
Язык: Английский
Impact of COVID-19 on gut–lung microbiota a mini review
Reviews in Medical Microbiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 27, 2024
The
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
that
causes
disease
2019
(COVID-19)
affects
the
lungs
and
gastrointestinal
tract.
However,
SARS-CoV-2
chiefly
infects
through
binding
of
angiotensin-converting
enzyme
(ACE2)
receptors
type
II
transmembrane
serine
protease
(TMPRSS2)
expressed
on
alveolar
epithelial
cells.
Furthermore,
intestinal
cells
also
express
ACE2
receptors.
Not
only
has
been
detected
in
nasopharyngeal
mid-nasal
samples,
but
it
seems
RNA
can
be
found
feces
infectious
patients.
In
fact,
fecal
samples
patients
contain
virus.
intensity
COVID-19
mainly
associated
with
aging
comorbidities.
Older
experience
a
decline
alteration
gut
microbiome,
proven
to
most
fatal
this
age
group,
further
emphasizing
potential
critical
role
microbiota
disease.
lung
was
formerly
believed
sterile
area
free
from
bacteria.
microbiome
received
more
attention
due
its
recent
link
several
illnesses
immunity.
review
article,
data
research
gut–lung
cross-talk
prognosis
explored
bidirectional
impacts
axis
were
discussed.
Язык: Английский