Clinical evaluation of pulmonary quantitative computed tomography parameters for diagnosing eosinophilic chronic obstructive pulmonary disease: Characteristics and diagnostic performance DOI Creative Commons
Yumeng Liu,

Chao Lu,

Wenfang Chen

и другие.

Health Science Reports, Год журнала: 2024, Номер 7(3)

Опубликована: Март 1, 2024

Abstract Aims To investigate the characteristics and diagnostic performance of quantitative computed tomography (QCT) parameters in eosinophilic chronic obstructive pulmonary disease (COPD) patients. Methods High‐resolution CT scans COPD patients were retrospectively analyzed, various emphysematous parenchyma measurements, including lung volume (LC), mean density (LMD), standard deviation (LSD), full‐width half maximum (FWHM), relative voxel number (LRVN) performed. The QCT compared between noneosinophilic patients, using a definition as blood eosinophil values ≥ 300 cells·µL −1 on at least three times. Receiver operating characteristic curves area under curve (ROC‐AUC) python used to evaluate discriminative efficacy QCT. Results Noneosinophilic had significantly lower TLMD (−846.3 ± 47.9 Hounsfield Unit [HU]) TFWHM(162.5 30.6 HU) (−817.8 54.4, 177.3 33.1 HU, respectively) ( p = 0.018, 0.03, respectively). Moreover, total LC (TLC) TLSD group (3234.4 1145.8, 183.8 33.9 than (5600.2 1248.4, 203.5 20.4 0.009, 0.002, ROC‐AUC for TLC, TLMD, TLSD, TFWHM 0.91 (95% confidence interval [CI], 0.828–0.936), 0.66 CI, 0.546–0.761), 0.64 0.524–0.742), 0.63 0.511–0.731), respectively. When TLC value was 4110 mL, sensitivity 90.7% 79.7–96.9), specificity 77.8% 57.7–91.4) accuracy 86.4%. Notably, demonstrated highest efficiency with an F1 Score 0.79, Odds Ratio 34.3 Matthews Correlation Coefficient 0.69, surpassing (0.55, 3.66, 0.25), (0.56, 3.95, 0.26), 4.16, 0.33). Conclusion Eosinophilic exhibit levels emphysema more uniform distribution throughout lungs Furthermore, may serve valuable marker distinguishing two groups.

Язык: Английский

Clinical evaluation of pulmonary quantitative computed tomography parameters for diagnosing eosinophilic chronic obstructive pulmonary disease: Characteristics and diagnostic performance DOI Creative Commons
Yumeng Liu,

Chao Lu,

Wenfang Chen

и другие.

Health Science Reports, Год журнала: 2024, Номер 7(3)

Опубликована: Март 1, 2024

Abstract Aims To investigate the characteristics and diagnostic performance of quantitative computed tomography (QCT) parameters in eosinophilic chronic obstructive pulmonary disease (COPD) patients. Methods High‐resolution CT scans COPD patients were retrospectively analyzed, various emphysematous parenchyma measurements, including lung volume (LC), mean density (LMD), standard deviation (LSD), full‐width half maximum (FWHM), relative voxel number (LRVN) performed. The QCT compared between noneosinophilic patients, using a definition as blood eosinophil values ≥ 300 cells·µL −1 on at least three times. Receiver operating characteristic curves area under curve (ROC‐AUC) python used to evaluate discriminative efficacy QCT. Results Noneosinophilic had significantly lower TLMD (−846.3 ± 47.9 Hounsfield Unit [HU]) TFWHM(162.5 30.6 HU) (−817.8 54.4, 177.3 33.1 HU, respectively) ( p = 0.018, 0.03, respectively). Moreover, total LC (TLC) TLSD group (3234.4 1145.8, 183.8 33.9 than (5600.2 1248.4, 203.5 20.4 0.009, 0.002, ROC‐AUC for TLC, TLMD, TLSD, TFWHM 0.91 (95% confidence interval [CI], 0.828–0.936), 0.66 CI, 0.546–0.761), 0.64 0.524–0.742), 0.63 0.511–0.731), respectively. When TLC value was 4110 mL, sensitivity 90.7% 79.7–96.9), specificity 77.8% 57.7–91.4) accuracy 86.4%. Notably, demonstrated highest efficiency with an F1 Score 0.79, Odds Ratio 34.3 Matthews Correlation Coefficient 0.69, surpassing (0.55, 3.66, 0.25), (0.56, 3.95, 0.26), 4.16, 0.33). Conclusion Eosinophilic exhibit levels emphysema more uniform distribution throughout lungs Furthermore, may serve valuable marker distinguishing two groups.

Язык: Английский

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