International Journal of Pharmaceutics, Год журнала: 2024, Номер 669, С. 125076 - 125076
Опубликована: Дек. 10, 2024
Язык: Английский
European Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер unknown, С. 107036 - 107036
Опубликована: Фев. 1, 2025
Cannabidiol (CBD), one of the main actives from Cannabis sativa has been perpetually explored lately for its therapeutic effects. Its attributes, such as anti-inflammatory and antioxidant effects, snowball into pain management, epilepsy seizure alleviation, anxiety relief, well numerous other implications through entire metabolism. However, conventional administration routes challenge potential, with reported poor water solubility, hepatic degradation, gastric instability erratic bioavailability observed in oral administration. As a result, transdermal delivery systems have emerged promising alternative to or inhaled routes, offering improved targeted The medical use CBD throughout Europe, UK, USA Australia is extensive usually represented by pharmaceutical preparations recommended after treatment routs fail. non-medical limited each country's own legislation, wider range products being available, but irregular regulatory landscape coupled growing market cannabinoid-infused products, emphasizes need standardized formulations further clinical research. present work critically examines cannabidiol, explores skin's potential route strategies involved using it systemic targeting. We highlighted key challenges provided insights CBD`s variable based on different methods, thus compiling literature-based absorption, distribution, metabolism, excretion (ADME) study. also explore role endocannabinoid system, function various conditions, effects associated CBD, particularly light varying legislation across countries. While breadth benefits compelling, essential emphasize ongoing nature research individual responses can vary significantly.
Язык: Английский
Процитировано
3
Health Science Reports, Год журнала: 2024, Номер 7(2)
Опубликована: Фев. 1, 2024
Cannabis and its various derivatives are commonly used for both recreational medicinal purposes. Cannabinoids have been shown to anti-inflammatory properties. Inflammation is an important component of wound healing the effect cannabinoids on has become a recent topic investigation. The objective this article perform comprehensive review literature summarize effects skin guide future avenues research.
Язык: Английский
Процитировано
12
Pharmaceutics, Год журнала: 2024, Номер 16(10), С. 1277 - 1277
Опубликована: Сен. 30, 2024
emerges as a noteworthy candidate for its medicinal potential, particularly in wound healing. This review article explores the efficacy of cannabis oil reducing reactive oxygen species (ROS) during healing acute and chronic wounds, comparing it to standard treatments. ROS, produced from various internal external sources, play crucial role development by causing cell tissue damage. Understanding ROS on skin wounds is essential, they act both signaling molecules contributors oxidative Cannabis oil, recognized antioxidant properties, may help mitigate damage scavenging upregulating antioxidative mechanisms, potentially enhancing emphasizes ongoing research future potential dermatological treatments, highlighted through clinical studies patent updates. Despite promising benefits, optimizing formulations therapeutic applications remains challenge, underscoring need further realize capabilities wounds.
Язык: Английский
Процитировано
7
Nutrients, Год журнала: 2025, Номер 17(5), С. 861 - 861
Опубликована: Фев. 28, 2025
Objectives/Background: The Cannabis genus contain a mixture of cannabinoids and other minor components which have been studied so far. In this narrative review, we highlight the main aspects polarized discussion between abuse toxicity versus benefits compounds found in sativa plant. Methods: We investigated databases such as PubMed, Google Scholar, Web Science World Anti-doping Agency (WADA) documents for scientific publications that can elucidate heated related to negative addiction, organ damage improved sports performance medical benefits, particularly athletes, some are promising nutrients. Results: Scientific arguments bring forward harmful effects cannabinoids, ethical legislative their usage doping substances sports. present synthesis metabolism cannabis along with identification methods routine anti-doping tests. Numerous studies attest beneficial effects, could therapeutic advantage athletes case injuries. These recommend nutrients, well potential pharmacological agents. Conclusions Future Perspectives: From perspective both illegal use investigators sport, there many interpretations, presented discussed review. Despite recent on species, is very little research active especially large groups compared placebo. may complete current vision topic clarify hypotheses launched discussions
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 7137 - 7137
Опубликована: Июнь 28, 2024
Cutaneous wounds, both acute and chronic, begin with loss of the integrity, thus barrier function, skin. Surgery trauma produce wounds. There are 22 million surgical procedures per year in United States alone, based on data from American College Surgeons, resulting a prevalence 6.67%. Acute traumatic wounds requiring repair total 8 year, 2.42% or 24.2 1000. The cost wound care is increasing; it approached USD 100 billion for just Medicare 2018. This burden will continue to rise population aging, increase metabolic syndrome, more elective surgeries. To heal wound, an orchestrated, evolutionarily conserved, complex series events involving cellular molecular agents at local systemic levels necessary. principal factors this important function include elements neurological, cardiovascular, immune, nutritional, endocrine systems. objectives review provide clinicians engaged basic science researchers interested healing updated synopsis recent publications. We also present our primary investigations, testing hypothesis that cannabidiol can alter cutaneous documenting their effects wild type (C57/BL6) db/db mice (Type 2 Diabetes Mellitus, T2DM). focus potential roles endocannabinoid system, cannabidiol, immune-regulatory cytokine IL-33, member IL-1 family, connective tissue growth factor, CTGF, due normal abnormal healing. found initial delay rate closure B6 CBD, but difference disappeared time. CBD decreased IL-33 + cells by 70% while nearly increasing CTGF two folds 18.6% 38.8% (p < 0.05) using dorsal model. current literature healing, document may have some beneficial diabetic applied 6-mm circular punch create standard size full-thickness mice. experimental group received control got only vehicle. outcome measures were closure, expressing ILC profiles. In B6, was slower there no time final significantly reduced. higher db/bd treated CBD. These support use improve
Язык: Английский
Процитировано
3
Pharmaceutics, Год журнала: 2024, Номер 16(8), С. 1081 - 1081
Опубликована: Авг. 17, 2024
This systematic review critically evaluates preclinical and clinical data on the antibacterial wound healing properties of cannabinoids in integument wounds. Comprehensive searches were conducted across multiple databases, including CINAHL, Cochrane library, Medline, Embase, PubMed, Web Science, LILACS, encompassing records up to May 22, 2024. Eighteen studies met inclusion criteria. Eleven animal studies, predominantly utilizing murine models (
Язык: Английский
Процитировано
3
Pharmaceuticals, Год журнала: 2025, Номер 18(5), С. 647 - 647
Опубликована: Апрель 28, 2025
Background: Cannabis sativa L. (C. sativa) has a long history of medicinal use. Its inflorescences contain bioactive compounds like non-psychotropic cannabidiol (CBD), which is well known for its anti-inflammatory potential in skin conditions such as psoriasis, and psychotropic Δ-9-tetrahydrocannabinol (THC). Keratinocytes, the main cells epidermis, are crucial regulating inflammation by producing mediators IL-8 when stimulated agents TNFα. Methods: This study explores effects standardized C. extract (CSE) with 5% CBD less than 0.2% THC human keratinocytes challenged The aim this to analyze specific contributions constituents CSE inflammatory responses fractionating examining individual components. Results: MTT assays showed that was non-toxic HaCaT up 50 μg/mL. inhibited NF-κB activity reduced secretion concentration-dependent manner, mean IC50 values 28.94 ± 10.40 μg/mL 20.06 2.78 (mean SEM), respectively. Fractionation into four subfractions revealed more lipophilic fractions (A B) were most effective inhibiting NF-κB, indicating cannabinoids cannflavins key contributors. Pure one active reducing NF-κB-driven transcription (together cannabigerol), due abundance CSE, it primarily responsible activity. Conclusions: highlights CBD’s significant role underscores need consider synergistic interactions several molecules within extracts maximum efficacy. Standardized essential reproducible results variability responses.
Язык: Английский
Процитировано
0
Gels, Год журнала: 2024, Номер 10(12), С. 843 - 843
Опубликована: Дек. 20, 2024
Chronic wounds represent a persistent clinical challenge due to prolonged inflammation and impaired tissue repair mechanisms. Cannabidiol (CBD), recognized for its anti-inflammatory pro-healing properties, shows therapeutic promise in wound care. However, delivery via lipid nanoparticles (LNPs) remains challenging CBD’s inherent instability low bioavailability. This study developed characterized novel hydrogel scaffold composed of CBD-loaded LNPs (CBD/LNPs) integrated into polyvinyl alcohol (PVA) sodium alginate (SA) matrix, designed enhance mitigate inflammation. The characteristics the were observed including degree swelling LNPs’ release profiles. Furthermore, results, CBD/LNPs displayed enhanced stability reduced cytotoxicity compared unencapsulated CBD. In vitro assays demonstrated that significantly promoted fibroblast migration gap-closure models intracellular reactive oxygen species, supporting their potential as biocompatible efficacious agent cellular oxidative stress attenuation. vivo experiments using adult male Wistar rats with aseptic cutaneous revealed treatment CBD/LNP-PVA/SA accelerated closure relative blank controls, demonstrating substantial reduction area over time. Histological analysis confirms notable improvements skin morphology treated evidence epithelialization, collagen deposition, increased dermal thickness vascularization. Additionally, histology showed more organized epidermal layer inflammatory cell infiltration scaffold-treated wounds, corresponding 35% increase rate by day 28 post-treatment. These findings suggest scaffolds facilitate resolution structural healing through localized, sustained CBD delivery. dual wound-healing effects position promising approach chronic management. Future investigations are warranted elucidate mechanistic pathways which modulates architecture explore translational applications
Язык: Английский
Процитировано
2
ACS Applied Bio Materials, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 20, 2024
This Perspective explores the potential of nonpsychoactive cannabinoids (NPCs) such as CBD, CBG, CBC, and CBN in developing innovative biomaterials for biomedical sports applications. It examines their physicochemical properties, anti-inflammatory, analgesic, neuroprotective effects, integration into various hydrogels, sponges, films, scaffolds. also discusses current challenges standardizing formulations, understanding long-term intrinsical regulatory landscapes. Further, it promising applications NPC-loaded materials bone regeneration, wound management, drug delivery systems, emphasizing improved biocompatibility, mechanical therapeutic efficacy demonstrated
Язык: Английский
Процитировано
1
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 4607 - 4649
Опубликована: Май 1, 2024
Abstract: Cannabinoids are compounds found in and derived from the Cannabis plants that have become increasingly recognised as significant modulating factors of physiological mechanisms inflammatory reactions organism, thus inevitably affecting maintenance homeostasis. Medical popularity has surged since its legal regulation growing around world. Numerous promising discoveries bring more data on cannabinoids' pharmacological characteristics therapeutic applications. Given current surge interest medical use cannabinoids, there is an urgent need for effective method their administration. Surpassing low bioavailability, water solubility, instability became important milestone advancement cannabinoids pharmaceutical The numerous uses clinical practice remain restricted by limited administration alternatives, but hope when biodegradable polymers taken into account. primary objective this review to highlight wide range indications which may be used, well polymeric carriers enhance effectiveness. described a applications including pain management, neurological sleep disorders, anxiety, cancer treatment. these was further examined area dermatology cosmetology. Finally, with polymer-based drug delivery systems (DDSs), it demonstrated can delivered specifically intended site while also improving drug's physicochemical properties, emphasizing utility. Nevertheless, additional trials novel formulations required, full spectrum therapeutical potential yet unravelled. Keywords: systems, cannabidiol, tetrahydrocannabinol, polymers, nanomedicine
Язык: Английский
Процитировано
0