An insight into bisphenol A, food exposure and its adverse effects on health: A review

Frontiers in Nutrition, Год журнала: 2022, Номер 9

Опубликована: Ноя. 3, 2022

Bisphenol A (BPA) is a synthetic chemical widely employed to synthesize epoxy resins, polymer materials, and polycarbonate plastics. BPA abundant in the environment, i.e., food containers, water bottles, thermal papers, toys, medical devices, etc., incorporated into soil/water through leaching. Being potent endocrine disrupter, has potential alter several body mechanisms. Studies confirmed its anti-androgen action estrogen-like effects, which impart many negative health impacts, especially on immune system, neuroendocrine process, reproductive mechanism. Moreover, it can also induce mutagenesis carcinogenesis, as per recent scientific research. This review focuses BPA's presence concentrations different environments, sources basic mechanisms of BPA-induced toxicity disruptions. It unique type because association cancer, hormonal disruption, immunosuppression, infertility with BPA. These issues are widespread today, significantly contributes their incidence wide usage daily life utensils other accessories. The discusses researched-based measures cope toxic chemical.

Язык: Английский

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The triple exposure nexus of microplastic particles, plastic-associated chemicals, and environmental pollutants from a human health perspective

Environment International, Год журнала: 2024, Номер 188, С. 108736 - 108736

Опубликована: Май 10, 2024

The presence of microplastics (MPs) is increasing at a dramatic rate globally, posing risks for exposure and subsequent potential adverse effects on human health. Apart from being physical objects, MP particles contain thousands plastic-associated chemicals (i.e., monomers, chemical additives, non-intentionally added substances) captured within the polymer matrix. These are often migrating MPs can be found in various environmental matrices food chains; health effects. In addition to attributes MPs, plastic surfaces effectively bind exogenous chemicals, including pollutants (e.g., heavy metals, persistent organic pollutants). Therefore, act as vectors pollution across air, drinking water, food, further amplifying posed by exposure. Critically, fragmentation plastics environment increases risk interactions with cells, available leach adsorb transfer pollutants. This review proposes so-called triple nexus approach comprehensively map existing knowledge interconnected particles, Based data, there large gap regard cumulative nexus. Each component known induce genotoxicity, inflammation, endocrine disruption, but about long-term inter-individual lacking. Furthermore, not readily excreted organisms after ingestion they have been accumulated blood, cardiac tissue, placenta, etc. Even though number studies MPs-associated impacts rapidly, this underscores that pressing necessity achieve an integrated assessment MPs' order address future gaps.

Язык: Английский

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The plastic health map: A systematic evidence map of human health studies on plastic-associated chemicals

Environment International, Год журнала: 2023, Номер 181, С. 108225 - 108225

Опубликована: Окт. 10, 2023

The global production and use of plastic materials has increased dramatically since the 1960s there is increasing evidence human health impacts related to exposure plastic-associated chemicals. There is, however, no comprehensive, regulatory, post-market monitoring for effects chemicals or particles it unclear how many these have been investigated in humans, therefore what knowledge gaps are.To create a systematic map peer-reviewed studies investigating potential particles/chemicals on identify research provide recommendations future regulation policy.Medline Embase databases were used primary published English from Jan 1960 - 2022 that relationships between exposures included measured detected bio-samples outcomes. Plastic-associated are: micro nanoplastics, due their widespread occurrence exposure; polymers, main building blocks plastic; plasticizers flame retardants, two most common types additives with highest concentration ranges materials; bisphenols per- polyfluoroalkyl substances, chemical classes known concern are plastics. We extracted metadata population study characteristics (country, intergenerational, sex, age, general/special risk status, design), (plastic-associated particle/chemical, multiple exposures), outcome measures (biochemical, physiological, and/or clinical), which we produced interactive database 'Plastic Health Map' narrative summary.We identified 100,949 unique articles, 3,587 met our inclusion criteria map. Plastic Map freely available at https://osf.io/fhw7d/ summary tables, plots overall observations this report.We present first compiling wide range several different classes, order stakeholders, including researchers, regulators, concerned individuals, an efficient way access literature matter determine gaps. also examples data clusters facilitate reviews help direct efforts. Extensive breadth populations, outcomes addressed No nanoplastics found, found 26/1,202 search hazard confirmed be active production. Few recent "substitution" restricted such as organophosphate phthalate substitutes, bisphenol analogues. call paradigm shift whereby new rigorously tested safety before being introduced consumer products, ongoing post-introduction biomonitoring levels humans throughout individuals' life span, old age across generations.

Язык: Английский

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Unpacking the complexity of the polyethylene food contact articles value chain: A chemicals perspective

Journal of Hazardous Materials, Год журнала: 2023, Номер 454, С. 131422 - 131422

Опубликована: Апрель 18, 2023

Polyethylene (PE) is the most widely used type of plastic food packaging, in which chemicals can potentially migrate into packaged foods. The implications using and recycling PE from a chemical perspective remain underexplored. This study systematic evidence map 116 studies looking at migration contact (FCCs) across lifecycle packaging. It identified total 377 FCCs, 211 were detected to articles or simulants least once. These FCCs checked against inventory databases EU regulatory lists. Only 25% are authorized by regulation for manufacture materials. Furthermore, quarter exceeded specific limit (SML) once, while one-third (53) non-authorised threshold value 10 μg/kg. Overall, on packaging incomplete, especially reprocessing stage. Considering EU's commitment increase recycling, better understanding monitoring quality entire will enable transition towards sustainable plastics chain.

Язык: Английский

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Synthetic Microfibers: An Urban Emerging Pollutant Demanding for Sustainable Environmental Solutions

Опубликована: Янв. 1, 2024

Язык: Английский

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Occurrence and abundance of microplastics and plasticizers in landfill leachate from open dumpsites in Sri Lanka

Environmental Pollution, Год журнала: 2024, Номер 350, С. 123944 - 123944

Опубликована: Апрель 10, 2024

Язык: Английский

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Microfluidics with redox-responsive hydrogels for on-demand BPA degradation

Chemical Engineering Journal, Год журнала: 2024, Номер 485, С. 149542 - 149542

Опубликована: Фев. 20, 2024

An innovative electrochemical microreactor leveraging redox-responsive hydrogels for the targeted removal of organic pollutants has been presented in this study.The centrepiece is a alginate hydrogel cross-linked with iron ions, capable controlling release Fe ions by an external electrical stimulus.The were used to activate persulfate, leading formation reactive sulfate and hydroxyl radicals situ.The system was tested continuous degradation radical oxidation using bisphenol A (BPA) as model system.This unique, responsive feature enables its modulation thus BPA on demand.In operation, efficiency over 94 % achieved, demonstrating enormous potential microfluidic setup environmental remediation various pollutants.By tailoring process conditions, such residence time, even complete achieved.The robust portable design should enable utilization at site contamination.Due efficient control achieved through design, study further delves into adaptability different matrices showcases promising solution increasing global threat water pollution.Thereby, research opens up new strategies niche-oriented pollution management, including model-based approaches.The CFD applied simulate optimize enabling intensification.

Язык: Английский

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Endocrine Disrupting Toxicity of Bisphenol A and Its Analogs: Implications in the Neuro-Immune Milieu

Journal of Xenobiotics, Год журнала: 2025, Номер 15(1), С. 13 - 13

Опубликована: Янв. 17, 2025

Endocrine-disrupting chemicals (EDCs) are natural or synthetic substances that able to interfere with hormonal systems and alter their physiological signaling. EDCs have been recognized as a public health issue due widespread use, environmental persistence the potential levels of long-term exposure implications in multiple pathological conditions. Their reported adverse effects pose critical concerns about warranting strict regulation. This is case bisphenol A (BPA), well-known EDC whose tolerable daily intake (TDI) was re-evaluated 2023 by European Food Safety Authority (EFSA), immune system has identified most sensitive BPA exposure. Increasing scientific evidence indicates can several hormone receptors, pathways interacting proteins, resulting complex, cell context-dependent response may differ among tissues. In this regard, neuronal important targets signaling now emerging players endocrine disruption. Here, we use its analogs proof-of-concept address detrimental on nervous highlight complex interrelationships within immune-neuroendocrine network (INEN). Finally, propose Receptor for Activated C Kinase 1 (RACK1), an target valuable screening tool, could serve central hub our toxicology model explain bisphenol-mediated INEN.

Язык: Английский

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Managing Bisphenol A Contamination: Advances in Removal Technologies and Future Prospects

Water, Год журнала: 2023, Номер 15(20), С. 3573 - 3573

Опубликована: Окт. 12, 2023

Increasing levels of bisphenol A (BPA), classified as an endocrine-disrupting compound, in the environment have raised concerns because its detrimental impact on human and animal health. BPA has been detected soil water even a volatile compound air primarily improper disposal extensive use production polycarbonate plastics epoxy resins. This review comprehensively surveyed recent research focusing removal from through physicochemical biological treatments, covering articles published 2002 to 2023. range conventional non-conventional methods employed for is examined, their limitations completely degrading are acknowledged. Hybrid or integrated treatment systems explored, capitalising distinctive potential various processes. The literature spanning 2023 underscores efficacy hybrid yielding promising results water. Furthermore, future directions outlined, advancements technologies developed over past decade incorporated.

Язык: Английский

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The role of fluorescent carbon dots in the fate of plastic waste

Journal of environmental chemical engineering, Год журнала: 2023, Номер 11(5), С. 110322 - 110322

Опубликована: Июнь 9, 2023

Язык: Английский

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