Immunosenescence and Inflammaging: Mechanisms and Role in Diseases
Ageing Research Reviews,
Год журнала:
2024,
Номер
101, С. 102540 - 102540
Опубликована: Окт. 10, 2024
Язык: Английский
Regulatory RNAs in immunosenescence
Immunity Inflammation and Disease,
Год журнала:
2024,
Номер
12(3)
Опубликована: Март 1, 2024
Abstract
Background
Immunosenescence
is
a
multifactorial
stress
response
to
different
intrinsic
and
extrinsic
insults
that
cause
immune
deterioration
accompanied
by
genomic
or
epigenomic
perturbations.
It
now
widely
recognized
genes
proteins
contributing
in
the
process
of
immunosenescence
are
regulated
various
noncoding
(nc)
RNAs,
including
microRNAs
(miRNAs),
long
ncRNAs,
circular
RNAs.
Aims
This
review
article
aimed
evaluate
regulatore
RNAs
roles
immunosenescence.
Methods
We
analyzed
publications
were
focusing
on
regulatory
several
aspects
Results
In
setting,
ncRNAs
have
been
found
play
at
both
transcriptional
post‐transcriptional
levels.
These
factors
cooperate
regulate
initiation
gene
expression
programs
sustaining
senescence
phenotype
proinflammatory
responses.
Conclusion
complex
with
pivotal
alterations
function
occurring
age.
The
extensive
network
drive
immunosenescence‐related
features
mainly
directed
variety
such
as
miRNAs,
lncRNAs,
circRNAs.
Latest
findings
about
regulation
innate
adaptive
cells
well
their
role
pathways,
provide
better
understanding
Язык: Английский
Mechanisms and Strategies of Immunosenescence Effects on Non-Small Cell Lung Cancer (NSCLC) Treatment: A Comprehensive Analysis and Future Directions
Seminars in Cancer Biology,
Год журнала:
2025,
Номер
109, С. 44 - 66
Опубликована: Янв. 9, 2025
Язык: Английский
Immunosenescence in digestive system cancers: mechanisms, research advances, and therapeutic strategies
Junyan Zhang,
Xiaojiao Guan,
Xinwen Zhong
и другие.
Seminars in Cancer Biology,
Год журнала:
2024,
Номер
106-107, С. 234 - 250
Опубликована: Ноя. 1, 2024
Язык: Английский
Characterizing Host microRNA: Virus Interactions of Orthoavulavirus javaense
Viruses,
Год журнала:
2024,
Номер
16(11), С. 1748 - 1748
Опубликована: Ноя. 7, 2024
Post-transcriptional
gene
regulation
mediated
by
microRNAs
(miRNAs)
relies
on
sequence
complementarity
between
the
miRNA
seed
site
and
target
transcript(s).
This
can
completely
inhibit
or
reduce
translation
into
protein.
We
hypothesized
that
viruses
employ
complementarity/similarity
with
host
miRNAs
to
increase
miRNA-mediated
of
expression
specifically
during
viral
infection(s).
In
this
study,
we
focus
Язык: Английский