Translational Neurodegeneration, Год журнала: 2024, Номер 13(1)

Опубликована: Дек. 24, 2024

Abstract Endosomes are crucial sites for intracellular material sorting and transportation. Endosomal transport is a critical process involved in the selective uptake, processing, of substances. The equilibrium between endocytosis circulation mediated by endosome-centered pathway plays significant role cell homeostasis, signal transduction, immune response. In recent years, there have been hints linking endosomal abnormalities to neurodegenerative diseases, including Alzheimer's disease. Nonetheless, related mechanisms remain unclear. Here, we provide an overview endosomal-centered pathways highlight potential physiological processes regulated these pathways, with particular focus on correlation trafficking disorders common pathological features diseases. Additionally, summarize therapeutic agents targeting treatment Graphical abstract

Язык: Английский